Impact of high doses of 6% hydroxyethyl starch 130/0.42 and 4% gelatin on renal function in a pediatric animal model

2015 ◽  
Vol 26 (3) ◽  
pp. 259-265 ◽  
Author(s):  
Lars Witt ◽  
Silke Glage ◽  
Ralf Lichtinghagen ◽  
Lars Pape ◽  
Dietmar Boethig ◽  
...  
Keyword(s):  
Animal Model ◽  
Renal Function ◽  
Hydroxyethyl Starch ◽  
High Doses

Impact of 6% hydroxyethyl starch 130/0.42 and 4% gelatin on renal function in a pediatric animal model

2014 ◽  
Vol 24 (9) ◽  
pp. 974-979 ◽  
Author(s):  
Lars Witt ◽  
Silke Glage ◽  
Katharina Schulz ◽  
Ralf Lichtinghagen ◽  
Arne Simann ◽  
...  
Keyword(s):  
Animal Model ◽  
Renal Function ◽  
Hydroxyethyl Starch

PP-164 THE EFFECT OF HYDROXYETHYL STARCH AS A PRIMING SOLUTION FOR CARDIOPULMONARY BYPASS ON RENAL FUNCTION

2013 ◽  
Vol 163 (3) ◽  
pp. S144
Author(s):  
H.A. Gürbüz ◽  
A.B. Durukan ◽  
A. Özyüksel ◽  
M. Yılmaz ◽  
R. Dogan ◽  
...  
Keyword(s):  
Renal Function ◽  
Cardiopulmonary Bypass ◽  
Hydroxyethyl Starch

scholarly journals Hydroxyethyl Starch 130/0.42 Effect’s on Renal Function in Patients After Cardiac Surgery: A Retrospective Cohort Analysis

2020 ◽  
Author(s):  
Benedict Morath ◽  
Andreas Meid ◽  
Johannes Rickmann ◽  
Jasmin Soethoff ◽  
Markus Verch ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Renal Function ◽  
Cardiac Surgery ◽  
Kidney Function ◽  
Hydroxyethyl Starch ◽  
Retrospective Cohort ◽  
Cohort Analysis ◽  
Kidney Injury ◽  
Retrospective Cohort Analysis ◽  
The Impact

Abstract Background: Fluid management is an everyday challenge in intensive care units worldwide. Data from recent trials suggest that the use of hydroxyethyl starch leads to a higher rate of acute kidney injury and mortality in septic patients. Evidence on the safety of hydroxyethyl starch used in postoperative cardiac surgery patients is lacking Methods: The aim was to determine the impact of postoperatively administered hydroxyethylstarch 130/0.42 on renal function and 90-day mortality compared to with or without balanced crystalloids in patients after elective cardiac surgery. A retrospective cohort analysis was performed including 2245 patients undergoing elective coronary artery bypass grafting or, aortic valve replacement, or a combination of both between 2015 - 2019. Acute kidney injury was defined according to the ‘kidney disease improving global outcomes’ criteria. Multivariate logistic regression yielded adjusted associations of postoperative hydroxyethyl starch administration with acute kidney injury during hospital stay and 90-day mortality. Linear mixed-effects models predicted trajectories of estimated glomerular filtration rates over the postoperative period to explore the impact of dosage and timing of hydroxyethyl starch administration.Results: A total of 1009 patients (45.0 %) suffered from acute kidney injury. Significantly less acute kidney injury of any stage occurred in patients receiving hydroxyethyl starch compared to patients receiving only crystalloids for fluid resuscitation (43.7 % vs. 51.2 % p=0.008). In multivariate analysis, the administration of hydroxyethyl starch showed a protective effect (OR 0.89 95% confidence interval (CI) (0.82-0.96)) which was less prominent in patients receiving only crystalloids (OR 0.98, 95% CI (0.95-1.00)). No association between hydroxyethyl starch and 90-day mortality (OR 1.05 95% CI (0.88-1.25)) was detected. Renal function trajectories were dose-dependent and biphasic and hydroxyethyl starch could even slow down the late postoperative decline of kidney function.Conclusion: This study showed no association between hydroxyethyl starch and the postoperative occurrence of acute kidney injury and may add evidence to the discussion about the use of hydroxyethyl starch in cardiac surgery patients. In addition, hydroxyethyl starch administered early after surgery in adequate low doses might even prevent the decline of the kidney function after cardiac surgery.

Elevated Plasma Aluminum Levels in Normal Infants Receiving Antacids Containing Aluminum

PEDIATRICS ◽  
1991 ◽  
Vol 87 (2) ◽  
pp. 148-151
Author(s):  
V. Marc Tsou ◽  
Rose M. Young ◽  
Michael H. Hart ◽  
Jon A. Vanderhoof
Keyword(s):  
Renal Function ◽  
Plasma Level ◽  
Normal Renal Function ◽  
Aluminum Toxicity ◽  
Control Group ◽  
Elevated Plasma ◽  
Careful Monitoring ◽  
Aluminum Level ◽  
Aluminum Accumulation ◽  
High Doses

Aluminum toxicity is a documented cause of encephalopathy, anemia, and osteomalacia. Excretion is primarily renal; therefore, patients with renal insufficiency are at risk for aluminum accumulation and toxicity. This has been demonstrated in uremic children treated with aluminum-containing antacids. The purpose of this study was to determine whether plasma aluminum levels were elevated in infants with normal renal function during prolonged aluminum-containing antacid use. Ten study infants (mean age = 5.8 months), who had been receiving antacids for at least 1 week, were compared with 16 control infants (mean age = 9.8 months) not receiving antacids. The study patients consumed 123 ± 16 mg/kg per day (mean ± SEM) of elemental aluminum for an average of 4.7 weeks. Their plasma aluminum level (37.2 ± 7.13 µg/L) was significantly greater than that of the control group (4.13 ± 0.66 µg/L) (P < .005). It is concluded that plasma aluminum levels may become elevated in infants with normal renal function who are consuming high doses of aluminum-containing antacids. The safety of antacids containing aluminum should not be assumed and they should be used judiciously in infants, with careful monitoring of the aluminum dose and plasma level.

The Effect of 6% Hydroxyethyl Starch 130/0.4 on Renal Function, Arterial Blood Pressure, and Vasoactive Hormones During Radical Prostatectomy

2015 ◽  
Vol 120 (3) ◽  
pp. 608-618 ◽  
Author(s):  
Anne Sophie Pinholt Kancir ◽  
Joergen Kühlwein Johansen ◽  
Niels Peter Ekeloef ◽  
Erling Bjerregaard Pedersen
Keyword(s):  
Blood Pressure ◽  
Renal Function ◽  
Radical Prostatectomy ◽  
Arterial Blood Pressure ◽  
Hydroxyethyl Starch ◽  
Arterial Blood ◽  
Vasoactive Hormones

Effects of a predominantly hydroxyethyl starch (HES)-based and a predominantly non HES-based fluid therapy on renal function in surgical ICU patients

2009 ◽  
Vol 35 (9) ◽  
pp. 1539-1547 ◽  
Author(s):  
Franziska Schabinski ◽  
Janaina Oishi ◽  
Fabio Tuche ◽  
Alain Luy ◽  
Yasser Sakr ◽  
...  
Keyword(s):  
Renal Function ◽  
Hydroxyethyl Starch ◽  
Fluid Therapy ◽  
Icu Patients ◽  
Surgical Icu

EFFECTS OF SEPSIS ON RENAL FUNCTION AND MORPHOLOGY IN AN ANIMAL MODEL

1982 ◽  
Vol 10 (3) ◽  
pp. 219
Author(s):  
Adam L. Linton ◽  
Arsenio Avila ◽  
Paul Sharkey ◽  
Andrew Petrakas ◽  
Richard J. Finley ◽  
...  
Keyword(s):  
Animal Model ◽  
Renal Function
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