scholarly journals The Efficacy and Safety of Qiming Granule for Dry Eye Disease: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 11 ◽  
Author(s):  
Maoyi Yang ◽  
Zhipeng Hu ◽  
Rensong Yue ◽  
Liangjun Yang ◽  
Boxun Zhang ◽  
...  
Keyword(s):  
Dry Eye ◽  
Meta Analysis ◽  
Tear Film ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Efficacy And Safety ◽  
Chinese Patent ◽  
Traditional Chinese Patent Medicine ◽  
Positive Results

BackgroundDry eye disease (DED) is a common complication in clinical practice. Qiming granule, a traditional Chinese patent medicine, is widely used in treating DED in China. However, its effect is still largely unknown.ObjectivesThis research aims to evaluate the efficacy and safety of QG on DED.MethodsThree English database and four Chinese databases without restriction on language and publication bias were searched. Qualified literature was selecting according to inclusion and exclusion criteria, extracted the data, and conducted a meta-analysis.ResultsA total of 11 articles were included in this meta-analysis. The methodological quality of included studies was low. The results showed that QG was effective for DED (RR:1.26, 95%CI:1.12 to 1.41, P=0.0001). The results combined with random effects model showed that QG could significantly prolong the tear film break up time (MD: 2.93, 95% CI: 2.22 to 3.65, P < 0.00001), increase the amount of tears in patients with DED (MD: 2.94, 95% CI: 1.83 to 4.04, P < 0.00001) and repair the corneal defects in patients (MD: -0.71, 95% CI: -1.25 to -0.17, P < 0.00001).ConclusionsThis study found that despite of the apparently positive results of some outcomes, it is premature to confirm the efficacy of QG in treating DED. More high-quality studies are still needed in the future to further confirm the efficacy and safety.

scholarly journals Cationic Thiolated Poly(aspartamide) Polymer as a Potential Excipient for Artificial Tear Formulations

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Mária Budai-Szűcs ◽  
Gabriella Horvát ◽  
Barnabás Áron Szilágyi ◽  
Benjámin Gyarmati ◽  
András Szilágyi ◽  
...  
Keyword(s):  
Dry Eye ◽  
Tear Film ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Eye Drops ◽  
Thiol Groups ◽  
Physiological Properties ◽  
Disulphide Bond Formation ◽  
Polymer Bearing

Dry eye disease is a relatively common ocular problem, which causes eye discomfort and visual disorders leading to a decrease in the quality of life. The aim of this study was to find a possible excipient for eye drop formulations, which is able to stabilize the tear film. A cationic thiolated polyaspartamide polymer, poly[(N-mercaptoethylaspartamide)-co-(N-(N′,N′-dimethylaminoethyl)aspartamide)] (ThioPASP-DME), was used as a potential vehicle. Besides satisfying the basic requirements, the chemical structure of ThioPASP-DME is similar to those of ocular mucins as it is a protein-like polymer bearing a considerable number of thiol groups. The solution of the polymer is therefore able to mimic the physiological properties of the mucins and it can interact with the mucus layer via disulphide bond formation. The resultant mucoadhesion provides a prolonged residence time and ensures protective effect for the corneal/conjunctival epithelium. ThioPASP-DME also has an antioxidant effect due to the presence of the thiol groups. The applicability of ThioPASP-DME as a potential excipient in eye drops was determined by means of ocular compatibility tests and through examinations of the interactions with the mucosal surface. The results indicate that ThioPASP-DME can serve as a potential eye drop excipient for the therapy of dry eye disease.

scholarly journals An Association Rule Analysis of Combined Acupoints for the Treatment of Patients with Dry Eye Disease

2020 ◽  
pp. 1-8
Author(s):  
Ya-Hsuan Lin ◽  
Hsein-Chang Wu ◽  
Po-Chun Hsieh ◽  
I-Shiang Tzeng ◽  
Shu-Ya Wu ◽  
...  
Keyword(s):  
Dry Eye ◽  
Association Rule ◽  
Binary Data ◽  
Meta Analysis ◽  
Poor Quality ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Film Instability ◽  
Breakup Time

<b><i>Background:</i></b> Dry eye disease (DED) has a higher incidence in old age and is seen predominantly in females worldwide. Neurosensory abnormalities, ocular surface inflammation and damage, film instability, and hyperosmolarity are major and proven pathologies responsible for a poor quality of life. Tear breakup time and Schirmer’s I test are predominantly used for the evaluation of primary outcomes in patients undergoing conventional treatment. A previous meta-analysis of some relevant studies proved that combination of acupoints could be more effective than single acupoint treatment. <b><i>Objectives:</i></b> The present study aimed to undertake association rule mining and examined the potential kernel acupoint combination in DED treatment constructed from the extracted randomized controlled trials (RCTs) based on a previous meta-analysis. <b><i>Methods:</i></b> We summarized 32 acupoints as binary data from the 12 eligible RCTs and analyzed them based on the Apriori algorithm. <b><i>Results:</i></b> TE23, BL2, ST2, ST1, EX-HN5, BL1, LI4, ST36, SP6, and KI3 were the 10 most frequently selected acupoints. The major associated rules in combination of acupoints were {TE23, LI4} ≥ {ST1} and {TE23, ST1} ≥ {LI4}, as inferred from 23 association rules. <b><i>Conclusions:</i></b> For acupuncture treatment of DED, combined TE23, LI4, and ST1 acupoints could be settled as the kernel of acupoint combination.

scholarly journals Corrigendum: The Efficacy and Safety of Qiming Granule for Dry Eye Disease: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 11 ◽  
Author(s):  
Maoyi Yang ◽  
Zhipeng Hu ◽  
Rensong Yue ◽  
Liangjun Yang ◽  
Boxun Zhang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Dry Eye ◽  
Meta Analysis ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Efficacy And Safety

Frequency and impact of individual symptoms on quality of life in dry eye disease in patients presenting to a tertiary care hospital

2021 ◽  
pp. 1-16
Author(s):  
Saba Ali Arif ◽  
Muhammad Ifraheem Khan ◽  
Muhammad Salman Abid ◽  
Ayla Babar ◽  
Mohammad Ali Arif ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Dry Eye ◽  
Tertiary Care ◽  
Tear Film ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Care Hospital ◽  
Cross Sectional ◽  
Department Of Ophthalmology

Abstract Objective: To assess the frequency of symptoms and impact on quality of life in individuals with dry eye disease. Methods: The cross-sectional, study was conducted from December 2018 to June 2019 at the outpatient clinic of the Department of Ophthalmology, Pakistan Institute of Medical Sciences, Islamabad, Pakistan, and comprised dry eye disease patients aged at least 13 years with ocular burning sensation, lacrimation, grittiness, photophobia, redness or itching. Tear Film Breakup time <10 sec and / or positive ocular surface staining >5 corneal spots, >9 conjunctival spots, lid margin staining ?2mm in length were used to diagnose the disease. Data was collected using the Dry Eye Quality of Life Score questionnaire. Data was analysed using SPSS 25. Results: of the 191 patients, 135(71%) were females and 56(29%) were males. The overall mean age was 39.8±16.6 years. Itching 155(81.2%), watering 151(79.1%) and burning 124(64.9%) were the most frequent symptoms, with watering (p<0.001) and photophobia (p=0.012) significantly impacting quality of life. Conclusions: The most common symptoms among patients of dry eye disease affecting their quality of life were itching, watering, burning, photophobia and low mood. Key Words: Quality of life in dry eye disease, Dry eye disease, Lacrimation, Photophobia, Continuous...

scholarly journals Association of Systemic Comorbidities with Dry Eye Disease

2020 ◽  
Vol 9 (7) ◽  
pp. 2040
Author(s):  
Motoko Kawashima ◽  
Masakazu Yamada ◽  
Chika Shigeyasu ◽  
Kazuhisa Suwaki ◽  
Miki Uchino ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Dry Eye ◽  
Tear Film ◽  
Health Utility ◽  
Dry Eye Disease ◽  
Background Information ◽  
Eye Disease ◽  
Cross Sectional ◽  
Significant Difference

We investigated the association between dry eye disease and systemic comorbidities, including dry eye subtype, quality of life (QOL) and health utility among patients with dry eye disease. This cross-sectional, observational study enrolled 449 patients with dry eye disease (386 females; mean age, 62.6 ± 15.7 [range, 21–90] years). Ophthalmic examination findings included tear film break-up time (TBUT), Schirmer I value and keratoconjunctival staining score. QOL and health utility were evaluated using the Dry Eye-Related Quality-of-Life Score (DEQS) and Human Utility Index Mark 3 (HUI-3), respectively. Background information, including systemic comorbidities, was obtained. Prevalence of systemic comorbidities was 48.8% (219/449). No significant difference occurred between DEQS and systemic comorbidity. However, patients with dry eye disease and systemic comorbidities (depression and insomnia) exhibited significantly worse ocular surface parameters, particularly regarding TBUT, than those without. Dry eye disease with insomnia or depression comorbidity significantly correlated with friction-related diseases (including conjunctivochalasis or lid wiper epitheliopathy). A high prevalence of several systemic comorbidities occurred in patients with dry eye disease. This study shows an association between ocular signs and systemic comorbidities, particularly depression and insomnia. Ophthalmologists should be aware of patients’ systemic comorbidities in the diagnosis and management of dry eye disease.

Tear Film Aberration Dynamics and Vision-Related Quality of Life in Patients with Dry Eye Disease

Ophthalmology ◽  
2012 ◽  
Vol 119 (9) ◽  
pp. 1811-1818 ◽  
Author(s):  
Alexandre Denoyer ◽  
Ghislaine Rabut ◽  
Christophe Baudouin
Keyword(s):  
Quality Of Life ◽  
Dry Eye ◽  
Tear Film ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Related Quality

scholarly journals Tear Proteomics Study of Dry Eye Disease: Which Eye Do You Adopt as the Representative Eye for the Study?

2021 ◽  
Vol 22 (1) ◽  
pp. 422
Author(s):  
Ming-Tse Kuo ◽  
Po-Chiung Fang ◽  
Shu-Fang Kuo ◽  
Alexander Chen ◽  
Yu-Ting Huang
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Tear Film ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Mechanistic Studies ◽  
Clinical Tests ◽  
Tear Proteins ◽  
Proteomic Data ◽  
Surface Performance

Most studies about dry eye disease (DED) chose unilateral eye for investigation and drew conclusions based on monocular results, whereas most studies involving tear proteomics were based on the results of pooling tears from a group of DED patients. Patients with DED were consecutively enrolled for binocular clinical tests, tear biochemical markers of DED, and tear proteome. We found that bilateral eyes of DED patients may have similar but different ocular surface performance and tear proteome. Most ocular surface homeostatic markers and tear biomarkers were not significantly different in the bilateral eyes of DED subjects, and most clinical parameters and tear biomarkers were correlated significantly between bilateral eyes. However, discrepant binocular presentation in the markers of ocular surface homeostasis and the associations with tear proteins suggested that one eye’s performance cannot represent that of the other eye or both eyes. Therefore, in studies for elucidating tear film homeostasis of DED, we may lose some important messages hidden in the fellow eye if we collected clinical and proteomic data only from a unilateral eye. For mechanistic studies, it is recommended that researchers collect tear samples from the eye with more severe DED under sensitive criteria for identifying the more severe eye and evaluating the tear biochemical and proteomic markers with binocular concordance drawn in prior binocular studies.

Oxidative and antioxidative stress markers in dry eye disease: A systematic review and meta‐analysis

2021 ◽  
Author(s):  
Valentin Navel ◽  
Vincent Sapin ◽  
Fanny Henrioux ◽  
Loïc Blanchon ◽  
Antoine Labbé ◽  
...  
Keyword(s):  
Systematic Review ◽  
Dry Eye ◽  
Meta Analysis ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Stress Markers ◽  
Antioxidative Stress

A distinct cytokines profile in tear film of dry eye disease (DED) patients with HIV infection

Cytokine ◽  
2016 ◽  
Vol 88 ◽  
pp. 77-84 ◽  
Author(s):  
Rupesh Agrawal ◽  
Praveen Kumar Balne ◽  
Anuradha Veerappan ◽  
Veonice Bijin Au ◽  
Bernett Lee ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Dry Eye ◽  
Tear Film ◽  
Dry Eye Disease ◽  
Eye Disease
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