scholarly journals Association of Systemic Comorbidities with Dry Eye Disease

2020 ◽  
Vol 9 (7) ◽  
pp. 2040
Author(s):  
Motoko Kawashima ◽  
Masakazu Yamada ◽  
Chika Shigeyasu ◽  
Kazuhisa Suwaki ◽  
Miki Uchino ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Dry Eye ◽  
Tear Film ◽  
Health Utility ◽  
Dry Eye Disease ◽  
Background Information ◽  
Eye Disease ◽  
Cross Sectional ◽  
Significant Difference

We investigated the association between dry eye disease and systemic comorbidities, including dry eye subtype, quality of life (QOL) and health utility among patients with dry eye disease. This cross-sectional, observational study enrolled 449 patients with dry eye disease (386 females; mean age, 62.6 ± 15.7 [range, 21–90] years). Ophthalmic examination findings included tear film break-up time (TBUT), Schirmer I value and keratoconjunctival staining score. QOL and health utility were evaluated using the Dry Eye-Related Quality-of-Life Score (DEQS) and Human Utility Index Mark 3 (HUI-3), respectively. Background information, including systemic comorbidities, was obtained. Prevalence of systemic comorbidities was 48.8% (219/449). No significant difference occurred between DEQS and systemic comorbidity. However, patients with dry eye disease and systemic comorbidities (depression and insomnia) exhibited significantly worse ocular surface parameters, particularly regarding TBUT, than those without. Dry eye disease with insomnia or depression comorbidity significantly correlated with friction-related diseases (including conjunctivochalasis or lid wiper epitheliopathy). A high prevalence of several systemic comorbidities occurred in patients with dry eye disease. This study shows an association between ocular signs and systemic comorbidities, particularly depression and insomnia. Ophthalmologists should be aware of patients’ systemic comorbidities in the diagnosis and management of dry eye disease.

Frequency and impact of individual symptoms on quality of life in dry eye disease in patients presenting to a tertiary care hospital

2021 ◽  
pp. 1-16
Author(s):  
Saba Ali Arif ◽  
Muhammad Ifraheem Khan ◽  
Muhammad Salman Abid ◽  
Ayla Babar ◽  
Mohammad Ali Arif ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Dry Eye ◽  
Tertiary Care ◽  
Tear Film ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Care Hospital ◽  
Cross Sectional ◽  
Department Of Ophthalmology

Abstract Objective: To assess the frequency of symptoms and impact on quality of life in individuals with dry eye disease. Methods: The cross-sectional, study was conducted from December 2018 to June 2019 at the outpatient clinic of the Department of Ophthalmology, Pakistan Institute of Medical Sciences, Islamabad, Pakistan, and comprised dry eye disease patients aged at least 13 years with ocular burning sensation, lacrimation, grittiness, photophobia, redness or itching. Tear Film Breakup time <10 sec and / or positive ocular surface staining >5 corneal spots, >9 conjunctival spots, lid margin staining ?2mm in length were used to diagnose the disease. Data was collected using the Dry Eye Quality of Life Score questionnaire. Data was analysed using SPSS 25. Results: of the 191 patients, 135(71%) were females and 56(29%) were males. The overall mean age was 39.8±16.6 years. Itching 155(81.2%), watering 151(79.1%) and burning 124(64.9%) were the most frequent symptoms, with watering (p<0.001) and photophobia (p=0.012) significantly impacting quality of life. Conclusions: The most common symptoms among patients of dry eye disease affecting their quality of life were itching, watering, burning, photophobia and low mood. Key Words: Quality of life in dry eye disease, Dry eye disease, Lacrimation, Photophobia, Continuous...

Tear Film Aberration Dynamics and Vision-Related Quality of Life in Patients with Dry Eye Disease

Ophthalmology ◽  
2012 ◽  
Vol 119 (9) ◽  
pp. 1811-1818 ◽  
Author(s):  
Alexandre Denoyer ◽  
Ghislaine Rabut ◽  
Christophe Baudouin
Keyword(s):  
Quality Of Life ◽  
Dry Eye ◽  
Tear Film ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Related Quality

scholarly journals Cationic Thiolated Poly(aspartamide) Polymer as a Potential Excipient for Artificial Tear Formulations

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Mária Budai-Szűcs ◽  
Gabriella Horvát ◽  
Barnabás Áron Szilágyi ◽  
Benjámin Gyarmati ◽  
András Szilágyi ◽  
...  
Keyword(s):  
Dry Eye ◽  
Tear Film ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Eye Drops ◽  
Thiol Groups ◽  
Physiological Properties ◽  
Disulphide Bond Formation ◽  
Polymer Bearing

Dry eye disease is a relatively common ocular problem, which causes eye discomfort and visual disorders leading to a decrease in the quality of life. The aim of this study was to find a possible excipient for eye drop formulations, which is able to stabilize the tear film. A cationic thiolated polyaspartamide polymer, poly[(N-mercaptoethylaspartamide)-co-(N-(N′,N′-dimethylaminoethyl)aspartamide)] (ThioPASP-DME), was used as a potential vehicle. Besides satisfying the basic requirements, the chemical structure of ThioPASP-DME is similar to those of ocular mucins as it is a protein-like polymer bearing a considerable number of thiol groups. The solution of the polymer is therefore able to mimic the physiological properties of the mucins and it can interact with the mucus layer via disulphide bond formation. The resultant mucoadhesion provides a prolonged residence time and ensures protective effect for the corneal/conjunctival epithelium. ThioPASP-DME also has an antioxidant effect due to the presence of the thiol groups. The applicability of ThioPASP-DME as a potential excipient in eye drops was determined by means of ocular compatibility tests and through examinations of the interactions with the mucosal surface. The results indicate that ThioPASP-DME can serve as a potential eye drop excipient for the therapy of dry eye disease.

Effect of Online Classes on Dry Eye Disease in Children: A Hospital Based Survey

2021 ◽  
Vol 37 (4) ◽  
Author(s):  
Sangameshwarayya Salimath ◽  
Salma Sultana ◽  
Brijesh Appasaheb Patil ◽  
Kalpana R Kulkarni ◽  
Shishir K. Nyamagoudar
Keyword(s):  
Dry Eye ◽  
Signs And Symptoms ◽  
Cross Sectional Study ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
P Value ◽  
Online Classes ◽  
Cross Sectional ◽  
Department Of Ophthalmology ◽  
Significant Difference

Purpose:  To determine the effect of online classes on dry eye disease in children. Study Design:  Cross sectional study. Place and Duration of Study:  Department of Ophthalmology HSK hospital, Navanagar, Bagalkot, India, from October 2020 to November 2020. Methods:  A total of 454 students attending online classes between the ages of 3 – 18 years were selected. Questionnaire was presented which included name, age, sex, residence, duration of online studies and duration in hours per day along with the various signs and symptoms according to SPEED questionnaire. Statistical analysis was performed using the IBM SPSS version 17. Quantitative variables were presented as mean ± standard deviation, while qualitative data was presented as frequency and percentages and compared by chi square test. P-value of < 0.005 was considered as significant. Results:  Of the 454 responses, 316 (69.6%) had symptoms of dry eye disease, of which 159 were girls and 157 boys. There was no significant difference between boys and girls. Children taking online classes for 2 – 3 hours and for 4 to 6 months duration were more affected by the dry eye disease. Based on severity of grading system, 246 (84.2%) had mild symptoms, 42 (9.3%) had moderate symptoms and 28 ([6.2%) had severe symptoms. One hundred and twenty children visited ophthalmologist and 28.5% had their treatment of dry eye started. Conclusion:  Online classes have resulted in increase in the frequency of dry eye disease in children. Proper education about the usage of screen time and educating parents about early treatment is essential. Key Words:  Dry eye disease, Symptoms, Headache, Online learning.

Depression, Stress, Quality of Life, and Dry Eye Disease in Korean Women

Cornea ◽  
2015 ◽  
Vol 34 (7) ◽  
pp. 733-738 ◽  
Author(s):  
Kyung-Sun Na ◽  
Kyungdo Han ◽  
Yong-Gyu Park ◽  
Chul Na ◽  
Choun-Ki Joo
Keyword(s):  
Quality Of Life ◽  
Dry Eye ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Korean Women

scholarly journals The negative effects of dry eye disease on quality of life and visual function

2020 ◽  
Vol 50 (7) ◽  
pp. 1611-1615
Author(s):  
Lee W. Guo O.D ◽  
Esen K. AKPEK
Keyword(s):  
Quality Of Life ◽  
Dry Eye ◽  
Visual Function ◽  
Dry Eye Disease ◽  
Treatment Modalities ◽  
Eye Disease ◽  
Negative Effects ◽  
Ocular Discomfort ◽  
Novel Devices

In recent years, dry eye has become a hot topic within ophthalmology and optometry, especially in regards to new frontiers in treatment modalities which include novel devices, procedures, and medications. However, some of the more understudied areas in dry eye involve its impact on quality of life. Although ocular discomfort symptoms are well known to be associated with dry eye, its negative effects on visual function remain underrecognized. This paper reviews these topics within the currently published literature to heighten awareness among clinicians.

scholarly journals Dry Eye Disease: Impact on Quality of Life and Vision

2013 ◽  
Vol 1 (2) ◽  
pp. 51-57 ◽  
Author(s):  
Miki Uchino ◽  
Debra A. Schaumberg
Keyword(s):  
Quality Of Life ◽  
Dry Eye ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Disease Impact

scholarly journals Role of Neuroticism and Perceived Stress on Quality of Life among Patients with Dry Eye Disease

2021 ◽  
Author(s):  
Napaporn Tananuvat ◽  
Sasiwimon Tansanguan ◽  
Nahathai Wongpakaran ◽  
Tinakon Wongpakaran
Keyword(s):  
Quality Of Life ◽  
Linear Regression ◽  
Perceived Stress ◽  
Dry Eye ◽  
Strong Predictor ◽  
Linear Regression Analysis ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Ocular Symptoms

Abstract BackgroundPatients with dry eye disease (DED) experience stress that may subsequently affect their quality of life (QOL). Little is known whether neuroticism, a personality trait sensitive to stress and hassle, has an impact on stress that is related to DED and QOL. This study aimed to examine such a relationship.MethodsA hospital-based, cross-sectional observational study was conducted. All participants completed the Dry Eye-Related Quality-of-Life Score (DEQS) questionnaire, a 5-level EQ-5D (EQ-5D-5L), Neuroticism Inventory (NI), and 10-Item Perceived Stress Scale (PSS). Hierarchical linear regression was applied to determine the predictive effect of the independent variables. ResultsIn all, 100 participants had mean age of 50.91±14.3 years, and females totaled 89.0%. The mean scores of the QOL related to DED, EQ5D, NI, and PSS were 45.44 ±22.0, 0.78± 0.21, 31.67± 9.1, and 18.53± 6.1, respectively. Hierarchical linear regression analysis showed that ocular symptoms were the strongest predictor for QOL either assessed by DEQS or EQ-5D, and its effect was lessened when perceived stress and neuroticism were added to the model. The final model explained up to 30-39% variance of the QOL, compared with 13-32% by ocular symptoms alone. QOL of the patients with DED, not only related to eye symptoms but general stress in life. More than that, neuroticism was found to be a strong predictor contributing to the QOL among patients with DED. More attention should be paid to these psychological factors when assessing the QOL of this population.

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