Frequency and impact of individual symptoms on quality of life in dry eye disease in patients presenting to a tertiary care hospital

2021 ◽  
pp. 1-16
Author(s):  
Saba Ali Arif ◽  
Muhammad Ifraheem Khan ◽  
Muhammad Salman Abid ◽  
Ayla Babar ◽  
Mohammad Ali Arif ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Dry Eye ◽  
Tertiary Care ◽  
Tear Film ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Care Hospital ◽  
Cross Sectional ◽  
Department Of Ophthalmology

Abstract Objective: To assess the frequency of symptoms and impact on quality of life in individuals with dry eye disease. Methods: The cross-sectional, study was conducted from December 2018 to June 2019 at the outpatient clinic of the Department of Ophthalmology, Pakistan Institute of Medical Sciences, Islamabad, Pakistan, and comprised dry eye disease patients aged at least 13 years with ocular burning sensation, lacrimation, grittiness, photophobia, redness or itching. Tear Film Breakup time <10 sec and / or positive ocular surface staining >5 corneal spots, >9 conjunctival spots, lid margin staining ?2mm in length were used to diagnose the disease. Data was collected using the Dry Eye Quality of Life Score questionnaire. Data was analysed using SPSS 25. Results: of the 191 patients, 135(71%) were females and 56(29%) were males. The overall mean age was 39.8±16.6 years. Itching 155(81.2%), watering 151(79.1%) and burning 124(64.9%) were the most frequent symptoms, with watering (p<0.001) and photophobia (p=0.012) significantly impacting quality of life. Conclusions: The most common symptoms among patients of dry eye disease affecting their quality of life were itching, watering, burning, photophobia and low mood. Key Words: Quality of life in dry eye disease, Dry eye disease, Lacrimation, Photophobia, Continuous...

scholarly journals Association of Systemic Comorbidities with Dry Eye Disease

2020 ◽  
Vol 9 (7) ◽  
pp. 2040
Author(s):  
Motoko Kawashima ◽  
Masakazu Yamada ◽  
Chika Shigeyasu ◽  
Kazuhisa Suwaki ◽  
Miki Uchino ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Dry Eye ◽  
Tear Film ◽  
Health Utility ◽  
Dry Eye Disease ◽  
Background Information ◽  
Eye Disease ◽  
Cross Sectional ◽  
Significant Difference

We investigated the association between dry eye disease and systemic comorbidities, including dry eye subtype, quality of life (QOL) and health utility among patients with dry eye disease. This cross-sectional, observational study enrolled 449 patients with dry eye disease (386 females; mean age, 62.6 ± 15.7 [range, 21–90] years). Ophthalmic examination findings included tear film break-up time (TBUT), Schirmer I value and keratoconjunctival staining score. QOL and health utility were evaluated using the Dry Eye-Related Quality-of-Life Score (DEQS) and Human Utility Index Mark 3 (HUI-3), respectively. Background information, including systemic comorbidities, was obtained. Prevalence of systemic comorbidities was 48.8% (219/449). No significant difference occurred between DEQS and systemic comorbidity. However, patients with dry eye disease and systemic comorbidities (depression and insomnia) exhibited significantly worse ocular surface parameters, particularly regarding TBUT, than those without. Dry eye disease with insomnia or depression comorbidity significantly correlated with friction-related diseases (including conjunctivochalasis or lid wiper epitheliopathy). A high prevalence of several systemic comorbidities occurred in patients with dry eye disease. This study shows an association between ocular signs and systemic comorbidities, particularly depression and insomnia. Ophthalmologists should be aware of patients’ systemic comorbidities in the diagnosis and management of dry eye disease.

scholarly journals DRY-EYE DISEASE AMONG MEDICAL PROFESSIONALS IN A TERTIARY CARE HOSPITAL IN WESTERN UP DURING THE LOCKDOWN PERIOD 2020 – A CROSSSECTIONAL STUDY.

2020 ◽  
pp. 1-4
Author(s):  
Neelima Mehrotra ◽  
Amrita Bajpai Mishra ◽  
Alia Yamin ◽  
Ruchi Saxena ◽  
Ashwani Srivastava
Keyword(s):  
Dry Eye ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Medical Professionals ◽  
Care Hospital ◽  
Human Beings ◽  
Ocular Surface Disease Index ◽  
Cross Sectional

Objective : To estimate the prevalence of dry-eye disease (DED) among medical professionals in a tertiary care hospital in Western UP during the lockdown period 2020. Materials & Methods : This was a cross-sectional hospital-based, observational study from 7th May 2020 till 14th May 2020, that included 50 medical professionals as subjects. The study compares the increase in the number of hours spent on Visual Display Terminals (VDTs) before and during the lockdown period 2020. This in-turn led to numerous ill-effects on human beings, out of which ocular manifestations like dry-eye disease has been on the rise. The study has been carried out in the form of questionnaire survey data – Ocular Surface Disease Index (OSDI) asking about the symptoms and various other parameters, related to dry eye. Results : The mean number of hours spent on VDTs before lockdown was 2.82±1.32 hours and during lockdown was 6.26±4.76 hours. In accordance with the OSDI scoring, 23/50 subjects developed DED. Out of these, 28% (14/50) had mild DED, 16% (8/50) had moderate DED, and only 2% (1/50) had severe DED. Prevalence of dry eye was directly proportionate to exposure time to VDT during the lockdown. Conclusion : The prevalence of dry-eye disease (DED) among medical professionals during the lockdown period 2020 was 46%. This was attributed to the increased dependence on VDTs for various purposes.

Tear Film Aberration Dynamics and Vision-Related Quality of Life in Patients with Dry Eye Disease

Ophthalmology ◽  
2012 ◽  
Vol 119 (9) ◽  
pp. 1811-1818 ◽  
Author(s):  
Alexandre Denoyer ◽  
Ghislaine Rabut ◽  
Christophe Baudouin
Keyword(s):  
Quality Of Life ◽  
Dry Eye ◽  
Tear Film ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Related Quality

scholarly journals Cationic Thiolated Poly(aspartamide) Polymer as a Potential Excipient for Artificial Tear Formulations

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Mária Budai-Szűcs ◽  
Gabriella Horvát ◽  
Barnabás Áron Szilágyi ◽  
Benjámin Gyarmati ◽  
András Szilágyi ◽  
...  
Keyword(s):  
Dry Eye ◽  
Tear Film ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Eye Drops ◽  
Thiol Groups ◽  
Physiological Properties ◽  
Disulphide Bond Formation ◽  
Polymer Bearing

Dry eye disease is a relatively common ocular problem, which causes eye discomfort and visual disorders leading to a decrease in the quality of life. The aim of this study was to find a possible excipient for eye drop formulations, which is able to stabilize the tear film. A cationic thiolated polyaspartamide polymer, poly[(N-mercaptoethylaspartamide)-co-(N-(N′,N′-dimethylaminoethyl)aspartamide)] (ThioPASP-DME), was used as a potential vehicle. Besides satisfying the basic requirements, the chemical structure of ThioPASP-DME is similar to those of ocular mucins as it is a protein-like polymer bearing a considerable number of thiol groups. The solution of the polymer is therefore able to mimic the physiological properties of the mucins and it can interact with the mucus layer via disulphide bond formation. The resultant mucoadhesion provides a prolonged residence time and ensures protective effect for the corneal/conjunctival epithelium. ThioPASP-DME also has an antioxidant effect due to the presence of the thiol groups. The applicability of ThioPASP-DME as a potential excipient in eye drops was determined by means of ocular compatibility tests and through examinations of the interactions with the mucosal surface. The results indicate that ThioPASP-DME can serve as a potential eye drop excipient for the therapy of dry eye disease.

scholarly journals Frequency of efficacy of topical cyclosporine 0.05% eye drops in the management of dry eyes

2021 ◽  
Vol 15 (6) ◽  
pp. 1384-1386
Author(s):  
M. Khalid ◽  
M. Rizwan ◽  
S. Khurshid
Keyword(s):  
Dry Eye ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Eye Drops ◽  
Care Hospital ◽  
Improvement Rate ◽  
Female Patients ◽  
Department Of Ophthalmology ◽  
Male Patients ◽  
Efficacy Of Treatment

Aim: To determine the efficacy of cyclosporine 0.05% for the management of patients of dry-eye disease presenting at tertiary care hospital. Methods: This cross sectional study was conducted at Department of Ophthalmology, Sahiwal Medical College, Sahiwal from March 2020 to September 2020 over the period of 6 months.Total 310 patients of dry eye were included in this study after scrutinized by inclusion criteria. All the selected patients were managed with cyclosporine 0.05% and efficacy of the drug was assessed. Results: Total 310 patients of dry eye disease were recruited. Mean age was 47.15 ± 3.61 years and mean duration of dry eye disease was 11.10 ± 1.75 months. Out of 310 patients, treatment was found effective in 225 (73%) patients. Efficacy of treatment was noted in 172(96.63%) male patients and in 53(40.15%) female patients. Significantly higher rate of efficacy was noted in male patients as compared to female patients with p value 0.000. Conclusion: Results of present study showed higher improvement rate of dry eye symptoms in cases of dry eye managed with cyclosporine 0.05%. Male patients were more victim of dry eye as compared to female patients and statistically significant association of efficacy with gender was observed. No association of efficacy of treatment with age group and duration of disease was observed. Keywords: Dry eye, cyclosporine, inflammation, immunomodulator agents.

scholarly journals Determination of Risk Factors and Treatment of Dry Eye Disease in Type 1 Diabetes Before Corneal Complications at Sindh Institute of Ophthalmology And Visual Sciences

2017 ◽  
Vol 11 (1) ◽  
pp. 355-361 ◽  
Author(s):  
Shehnilla Shujaat ◽  
Muhammad Jawed ◽  
Shahzad Memon ◽  
Khalid Iqbal Talpur
Keyword(s):  
Risk Factors ◽  
Type 1 Diabetes ◽  
Dry Eye ◽  
Tear Film ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Diabetic Patients ◽  
Dry Eyes ◽  
Department Of Ophthalmology

Objective: The objective of this study was to assess and determine the risk factors and treatment of dry eye disease in type 1 diabetes before any ocular surface or corneal complication occurs. This study was conducted at Sindh Institute of Ophthalmology And Visual Sciences, Hyderabad, Pakistan. Methodology: Subjects and methods for observational study were undertaken at the Department of Ophthalmology Sindh Institute Of Ophthalmology And Visual Sciences, Hyderabad, Pakistan. Hundred confirmed cases of type 1 diabetes were included in the study by non probability convenience sampling. Tear film breakup time and schrimer test were carried out to determine dry eye disease. Data was collected by self-prepared questionnaire and entered and analyzed by using Statistical Program for Social Sciences (SPSS, version 20.0). The frequencies and percentage were recorded and any associations with predisposing factors were statistically analyzed by t test. Results: Out of hundred patients, 71 (71%) were found to have dry eyes (P<0.001). The mean age of the subject in this study was 50.97 years (range 30-70 years). Old age was related to high risk of dry eye disease (P<0.001). There was no big difference in the incidence of dry eyes in males and females. Long duration was found to be related with increased occurrence of dry eyes (P<0.001). We found higher values for abnormal tear film break up time than schirmer test values leading to increased occurrence of evaporative dry eyes. Conclusion: There is marked increase in frequency/ risk of developing dry eye disease in type 1 diabetes patients. Therefore, it is recommended to have periodic ophthalmic examination for type 1 diabetic patients.

Sign in / Sign up

Export Citation Format

Share Document