scholarly journals Anti-Cancer Effects of Panax ginseng Berry Polysaccharides via Activation of Immune-Related Cells

2019 ◽  
Vol 10 ◽  
Author(s):  
Dae-Young Lee ◽  
Chan Woong Park ◽  
Sue Jung Lee ◽  
Hye-Ryung Park ◽  
Su Hwan Kim ◽  
...  
Keyword(s):  
Panax Ginseng ◽  
Anti Cancer

Recent Advances in Ginsenosides as Potential Therapeutics Against Breast Cancer

2019 ◽  
Vol 19 (25) ◽  
pp. 2334-2347 ◽  
Author(s):  
Yu-hang Guo ◽  
Revathimadhubala Kuruganti ◽  
Ying Gao
Keyword(s):  
Breast Cancer ◽  
Panax Ginseng ◽  
Clinical Studies ◽  
Metastatic Breast ◽  
Panax Quinquefolius ◽  
Growth Modulation ◽  
Cancer Symptoms ◽  
Cancer Support ◽  
Recent Advances ◽  
Anti Cancer

The dried root of ginseng (Panax ginseng C. A. Meyer or Panax quinquefolius L.) is a traditional Chinese medicine widely used to manage cancer symptoms and chemotherapy side effects in Asia. The anti-cancer efficacy of ginseng is attributed mainly to the presence of saponins, which are commonly known as ginsenosides. Ginsenosides were first identified as key active ingredients in Panax ginseng and subsequently found in Panax quinquefolius, both of the same genus. To review the recent advances on anti-cancer effects of ginsenosides against breast cancer, we conducted a literature study of scientific articles published from 2010 through 2018 to date by searching the major databases including Pubmed, SciFinder, Science Direct, Springer, Google Scholar, and CNKI. A total of 50 articles authored in either English or Chinese related to the anti-breast cancer activity of ginsenosides have been reviewed, and the in vitro, in vivo, and clinical studies on ginsenosides are summarized. This review focuses on how ginsenosides exert their anti-breast cancer activities through various mechanisms of action such as modulation of cell growth, modulation of the cell cycle, modulation of cell death, inhibition of angiogenesis, inhibition of metastasis, inhibition of multidrug resistance, and cancer immunemodulation. In summary, recent advances in the evaluation of ginsenosides as therapeutic agents against breast cancer support further pre-clinical and clinical studies to treat primary and metastatic breast tumors.

scholarly journals Anti-Angiogenic Properties of Ginsenoside Rg3

Molecules ◽  
2020 ◽  
Vol 25 (21) ◽  
pp. 4905
Author(s):  
Maryam Nakhjavani ◽  
Eric Smith ◽  
Amanda R. Townsend ◽  
Timothy J. Price ◽  
Jennifer E. Hardingham
Keyword(s):  
Effective Dose ◽  
Panax Ginseng ◽  
Dose Range ◽  
Ginsenoside Rg3 ◽  
Anti Cancer

Ginsenoside Rg3 (Rg3) is a member of the ginsenoside family of chemicals extracted from Panax ginseng. Like other ginsenosides, Rg3 has two epimers: 20(S)-ginsenoside Rg3 (SRg3) and 20(R)-ginsenoside Rg3 (RRg3). Rg3 is an intriguing molecule due to its anti-cancer properties. One facet of the anti-cancer properties of Rg3 is the anti-angiogenic action. This review describes the controversies on the effects and effective dose range of Rg3, summarizes the evidence on the efficacy of Rg3 on angiogenesis, and raises the possibility that Rg3 is a prodrug.

Ginsenoside Rp1 from Panax ginseng Exhibits Anti-cancer Activity by Down-regulation of the IGF-1R/Akt Pathway in Breast Cancer Cells

2011 ◽  
Vol 66 (3) ◽  
pp. 298-305 ◽  
Author(s):  
Ju-Hee Kang ◽  
Ki-Hoon Song ◽  
Jong-Kyu Woo ◽  
Myung Hwan Park ◽  
Man Hee Rhee ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Panax Ginseng ◽  
Breast Cancer Cells ◽  
Akt Pathway ◽  
Down Regulation ◽  
Anti Cancer ◽  
Cancer Activity

scholarly journals Anti-Cancer Effect of Panax Ginseng and Its Metabolites: From Traditional Medicine to Modern Drug Discovery

Processes ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 1344
Author(s):  
Sejin Kim ◽  
Nayeon Kim ◽  
JaYeon Jeong ◽  
Soojin Lee ◽  
Woojin Kim ◽  
...  
Keyword(s):  
Natural Products ◽  
Cancer Therapy ◽  
Panax Ginseng ◽  
Cancer Development ◽  
Screening Tests ◽  
Mesenchymal Transition ◽  
Stage Of Development ◽  
Incidence And Mortality ◽  
Wide Range ◽  
Anti Cancer

Cancer incidence and mortality rate are growing worldwide. The effectiveness of cancer therapy depends on the degree of cancer development. Anticancer prevention, screening tests, detection of precancerous conditions or cancers at an early stage of development help to prevent the development of cancer, and in the event of cancer development, they provide the best chance for a full recovery. However, in most cases of advanced cancer, there is no method that can fully cure this disease. Recently, natural products have gained more attention in cancer therapy. Panax ginseng (PG), one of the most popular natural products, is reported to have a wide range of pharmacological activities in cancer. Therefore, the anti-cancer effects and mechanisms of PG and its metabolites (compound K, Ginsenoside Rh1, Rh2, Rh3 and F1) in five major cancers (lung cancer, breast cancer, colon cancer, prostate cancer and stomach cancer) are reviewed in this study. It is confirmed that PG and its metabolites regulated apoptosis, epithelial mesenchymal transition (EMT), angiogenesis, cell cycle arrest and multidrug resistance (MDR) in vitro and in vivo cancer models. In particular, ginsenoside Rh2 showed anticancer effects in all five major cancers. This review could improve the understanding of anticancer mechanisms of PG and its metabolites against major five cancers. Further clinical studies are needed for development anti-cancer drugs using PG and its metabolites.

scholarly journals Screening of Drug Metabolizing Enzymes for the Ginsenoside Compound K In Vitro: An Efficient Anti-Cancer Substance Originating from Panax Ginseng

PLoS ONE ◽  
2016 ◽  
Vol 11 (2) ◽  
pp. e0147183 ◽  
Author(s):  
Jian Xiao ◽  
Dan Chen ◽  
Xiu-Xian Lin ◽  
Shi-Fang Peng ◽  
Mei-Fang Xiao ◽  
...  
Keyword(s):  
Panax Ginseng ◽  
Drug Metabolizing Enzymes ◽  
Compound K ◽  
Metabolizing Enzymes ◽  
Anti Cancer ◽  
Ginsenoside Compound K

Ultra-sonication-assisted silver nanoparticles using Panax ginseng root extract and their anti-cancer and antiviral activities

2018 ◽  
Vol 188 ◽  
pp. 6-11 ◽  
Author(s):  
T.V.M. Sreekanth ◽  
P.C. Nagajyothi ◽  
P. Muthuraman ◽  
G. Enkhtaivan ◽  
S.V.P. Vattikuti ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Panax Ginseng ◽  
Ginseng Root ◽  
Root Extract ◽  
Anti Cancer ◽  
Antiviral Activities

In vitro anti-cancer activity and structure–activity relationships of natural products isolated from fruits of Panax ginseng

2006 ◽  
Vol 59 (5) ◽  
pp. 589-601 ◽  
Author(s):  
Wei Wang ◽  
Yuqing Zhao ◽  
Elizabeth R. Rayburn ◽  
Donald L. Hill ◽  
Hui Wang ◽  
...  
Keyword(s):  
Natural Products ◽  
Panax Ginseng ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Anti Cancer ◽  
Cancer Activity

scholarly journals Phytoconstituents and Biological Activities of Panax vietnamensis (Vietnamese Ginseng): A Precious Ginseng and Call for Further Research-A systematic review

2018 ◽  
Vol 13 (10) ◽  
pp. 1934578X1801301 ◽  
Author(s):  
Quang-Ung Le ◽  
Horng-Liang Lay ◽  
Ming-Chang Wu ◽  
Thi Hong-Hanh Nguyen ◽  
Duy-Lam Nguyen
Keyword(s):  
Systematic Review ◽  
Panax Ginseng ◽  
Biological Activities ◽  
Folk Medicine ◽  
Future Prospects ◽  
Mountain Areas ◽  
Functional Attributes ◽  
Anti Cancer ◽  
The World ◽  
Medicinal Food

Panax vietnamensis Ha et Grushv., a Vietnamese ginseng, is a well-known plant, naturally distributed in the Ngoc Linh and Hoang Lien Son mountain areas in Vietnam. It is used as a tonic and medicinal food in traditional folk medicine because it possesses wondrous health benefits. To support its functional attributes, various investigations have been carried out to find out its anti-inflammatory, anti-cancer, anti-stress, anti-nociception, psychomotor and sedative-hypnotic effects and anxiolytic activities. Also similar to other ginsengs, Vietnamese ginseng is a rich source of saponins and it has higher content of protopanaxadiol-, protopanaxatrial- and ocotillol-type saponins compared to other ginsengs in the world. Majonoside R2 is a main saponin in Vietnamese ginseng but this compound does not exist in Panax ginseng. Based on this systematic review, we discussed for future prospects and suggest that thorough scientific scrutiny is necessary in future researches.

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