scholarly journals c-Abl Inhibition Exerts Symptomatic Antiparkinsonian Effects Through a Striatal Postsynaptic Mechanism

2018 ◽  
Vol 9 ◽  
Author(s):  
Yu Zhou ◽  
Yukio Yamamura ◽  
Masatoshi Ogawa ◽  
Ryosuke Tsuji ◽  
Koichiro Tsuchiya ◽  
...  
Keyword(s):  
Postsynaptic Mechanism

The effects of focal stimulation in nucleus raphe magnus and periaqueductal gray on intracellularly recorded neurons in spinal laminae I and II

1986 ◽  
Vol 56 (3) ◽  
pp. 555-571 ◽  
Author(s):  
A. R. Light ◽  
E. J. Casale ◽  
D. M. Menetrey
Keyword(s):  
Brain Stem ◽  
Periaqueductal Gray ◽  
The Other ◽  
Descending Pathways ◽  
Nucleus Raphe Magnus ◽  
Raphe Magnus ◽  
Low Threshold ◽  
Conductance Increase ◽  
Small Conductance ◽  
Postsynaptic Mechanism

Single neurons in spinal laminae I and II of cats were recorded intracellularly while stimulating in nucleus raphe magnus (NRM) and periaqueductal gray (PAG) with monopolar tungsten microelectrodes. Brain stem stimulation inhibited about one-half of the nociceptive-specific neurons, whereas the other half was unaffected. Brain stem stimulation inhibited about one-half of the multireceptive neurons, but the other half was excited and then inhibited. Brain stem stimulation inhibited about one-third of the low-threshold neurons, one-half was excited then inhibited, and one-fifth showed no effect. In all classes of neurons, the inhibition was produced by an inhibitory postsynaptic potential (IPSP) that began with a latency of approximately 25 ms and lasted approximately 400 ms following a single stimulus. The IPSP occurred with a small conductance increase and was reversed by hyperpolarizing currents applied to the cell. These data indicate that NRM and PAG modulated laminae I and II neurons via a postsynaptic mechanism. The conduction velocity of this descending pathway was calculated to range from 6.1 to 66.6 m/s with an average of 13.8 m/s. These data also indicate heterogeneity in the pathway, since some neurons were inhibited, whereas other neurons were excited then inhibited by descending stimulation. Finally, these data indicate specificity in these descending pathways since nearly one-half of neurons that had low-threshold inputs were excited by brain stem stimulation, whereas nearly all nociceptive-specific neurons were either inhibited or unaffected.

Unilateral photoreceptor rescue can improve the ability of the opposite, untreated, eye to drive cortical cells in a retinal degeneration model

2005 ◽  
Vol 22 (1) ◽  
pp. 37-43 ◽  
Author(s):  
S.V. GIRMAN ◽  
R.D. LUND
Keyword(s):  
Cell Transplantation ◽  
Royal College ◽  
Visual Stimulation ◽  
Ocular Dominance ◽  
Photoreceptor Degeneration ◽  
Cortical Cells ◽  
Cortical Responses ◽  
Visual Cortical ◽  
Postsynaptic Mechanism ◽  
Stimulation Of

In the Royal College of Surgeons, rat photoreceptor degeneration occurs over the first several months of life, causing deterioration of visual cortical responsiveness seen as greater numbers of cells being nonresponsive to visual stimulation, poor tuning of those cells that do respond, and an overall tendency for domination by the contralateral visual input. If the progress of degeneration in one eye is slowed by intraretinal cell transplantation, cortical responses to stimulation of the remaining, untreated, eye are much stronger, better tuned and histograms of ocular dominance resemble more those in normal rats. This suggests that the rescued eye is able to enhance performance in the untreated eye by some form of postsynaptic mechanism.

5-HT1A receptor agonists induce anterograde amnesia in mice through a postsynaptic mechanism

1993 ◽  
Vol 236 (2) ◽  
pp. 177-182 ◽  
Author(s):  
Scott D. Mendelson ◽  
David Quartermain ◽  
Tiffani Francisco ◽  
Anne Shemer
Keyword(s):  
Anterograde Amnesia ◽  
Receptor Agonists ◽  
Postsynaptic Mechanism

scholarly journals Silent synapses and the emergence of a postsynaptic mechanism for LTP

2008 ◽  
Vol 9 (11) ◽  
pp. 813-825 ◽  
Author(s):  
Geoffrey A. Kerchner ◽  
Roger A. Nicoll
Keyword(s):  
Silent Synapses ◽  
Postsynaptic Mechanism

scholarly journals Multiple forms of LTP in hippocampal CA3 neurons use a common postsynaptic mechanism

10.1038/10180 ◽  
1999 ◽  
Vol 2 (7) ◽  
pp. 625-633 ◽  
Author(s):  
Mark F. Yeckel ◽  
Ajay Kapur ◽  
Daniel Johnston
Keyword(s):  
Multiple Forms ◽  
Hippocampal Ca3 ◽  
Ca3 Neurons ◽  
Postsynaptic Mechanism

Synaptic transmission: long-lasting potentiation by a postsynaptic mechanism

Science ◽  
1976 ◽  
Vol 194 (4272) ◽  
pp. 1437-1439 ◽  
Author(s):  
J. Schulman ◽  
F. Weight
Keyword(s):  
Synaptic Transmission ◽  
Postsynaptic Mechanism
Sign in / Sign up

Export Citation Format

Share Document