scholarly journals No Acute Effects of Cannabidiol on the Sleep-Wake Cycle of Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study

2018 ◽  
Vol 9 ◽  
Author(s):  
Ila M. P. Linares ◽  
Francisco S. Guimaraes ◽  
Alan Eckeli ◽  
Ana C. S. Crippa ◽  
Antonio W. Zuardi ◽  
...  
Keyword(s):  
Crossover Study ◽  
Healthy Subjects ◽  
Acute Effects ◽  
Double Blind ◽  
Double Blind Placebo

scholarly journals Erratum to: Effects of acotiamide on esophageal motility in healthy subjects: a randomized, double-blind, placebo-controlled crossover study

Esophagus ◽  
2017 ◽  
Vol 14 (3) ◽  
pp. 272-273
Author(s):  
Shintaro Hoshino ◽  
Nana Takenouchi ◽  
Yuriko Hanada ◽  
Mariko Umezawa ◽  
Hirohito Sano ◽  
...  
Keyword(s):  
Crossover Study ◽  
Esophageal Motility ◽  
Healthy Subjects ◽  
Double Blind ◽  
Double Blind Placebo

Effects of acotiamide on esophageal motility in healthy subjects: a randomized, double-blind, placebo-controlled crossover study

Esophagus ◽  
2016 ◽  
Vol 14 (2) ◽  
pp. 146-152 ◽  
Author(s):  
Shintaro Hoshino ◽  
Nana Takenouchi ◽  
Yuriko Hanada ◽  
Mariko Umezawa ◽  
Hirohito Sano ◽  
...  
Keyword(s):  
Crossover Study ◽  
Esophageal Motility ◽  
Healthy Subjects ◽  
Double Blind ◽  
Double Blind Placebo

Respiratory Safety of Lemborexant in Healthy Subjects: A Single-Dose, Randomized, Double-Blind, Placebo-Controlled, Crossover Study

2021 ◽  
Author(s):  
Jocelyn Y. Cheng ◽  
Margaret Moline ◽  
Gary K. Zammit ◽  
Gleb Filippov ◽  
Mohammad Bsharat ◽  
...  
Keyword(s):  
Single Dose ◽  
Crossover Study ◽  
Healthy Subjects ◽  
Double Blind ◽  
Double Blind Placebo

scholarly journals A Phase 1, Randomized, Double-blind, Placebo-controlled, Crossover Study to Evaluate the Pharmacodynamic Effects of VX-150, a highly selective NaV1.8 inhibitor, in Healthy Male Adults

Pain Medicine ◽  
2021 ◽  
Author(s):  
H J (Hemme) Hijma ◽  
P S (Pieter) Siebenga ◽  
M L (Marieke) de Kam ◽  
G J (Geert Jan) Groeneveld
Keyword(s):  
Crossover Study ◽  
Repeated Measures ◽  
Healthy Subjects ◽  
Cold Pressor ◽  
Pain Tolerance ◽  
Healthy Male ◽  
Post Dose ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Pain Tests

Abstract Objective To evaluate the analgesic potential, safety, tolerability and pharmacokinetics of VX-150, a pro-drug of a highly selective NaV1.8 inhibitor, in healthy subjects. Design This was a randomized, double-blind, placebo-controlled, crossover study in healthy subjects. Subjects Twenty healthy male subjects with an age of 18-55, inclusive, were enrolled. Eligibility was based on general fitness, absence of current or previous medical conditions that could compromise subject safety and a training assessment of pain tolerance across pain tests, to exclude highly tolerant individuals that could compromise the ability to detect analgesic responses. All dosed subjects completed the study. Methods Subjects were randomized 1:1 to 1 of 2 sequences receiving a single VX-150 dose and subsequently placebo, or vice versa, with at least 7 days between dosing. A battery of pain tests (pressure, electrical stair, (capsaicin-induced) heat and cold pressor) was administered pre-dose and repetitively up to 10 h post-dose, with blood sampling up to 24 h post-dose. Safety was monitored throughout the study. Data were analyzed with a repeated measures mixed-effects model. Results VX-150 induced analgesia in a variety of evoked pain tests, without affecting subject safety. Significant effects were reported for cold pressor and heat pain thresholds. Maximum median concentration for the active moiety was 4.30 ug/mL at 4 h post-dose. Conclusion Results of this proof-of-mechanism study are supportive of the potential of VX-150, a highly selective NaV1.8 channel inhibitor, to treat various pain indications.

Muscle fiber conduction velocity and EMG amplitude of the upper trapezius muscle in healthy subjects after low-level laser irradiation: a randomized, double-blind, placebo-controlled, crossover study

2017 ◽  
Vol 33 (4) ◽  
pp. 737-744 ◽  
Author(s):  
Fabiana Sarilho de Mendonça ◽  
Paulo de Tarso Camillo de Carvalho ◽  
Daniela Aparecida Biasotto-Gonzalez ◽  
Simone Aparecida Penimpedo Calamita ◽  
Cid André Fidelis de Paula Gomes ◽  
...  
Keyword(s):  
Crossover Study ◽  
Healthy Subjects ◽  
Trapezius Muscle ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Muscle Fiber Conduction Velocity ◽  
Upper Trapezius ◽  
Level Laser ◽  
Upper Trapezius Muscle ◽  
Low Level Laser Irradiation
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