scholarly journals Bloodstream Infection Incidence of Different Central Venous Catheters in Neonates: A Descriptive Cohort Study

2017 ◽  
Vol 5 ◽  
Author(s):  
Gerdina H. Dubbink-Verheij ◽  
Vincent Bekker ◽  
Iris C. M. Pelsma ◽  
Erik W. van Zwet ◽  
Vivianne E. H. J. Smits-Wintjens ◽  
...  
Keyword(s):  
Cohort Study ◽  
Bloodstream Infection ◽  
Central Venous Catheters ◽  
Central Venous ◽  
Infection Incidence

Cohort Study of the Pathogenesis and Molecular Epidemiology of Catheter-Related Bloodstream Infection in Neonates With Peripherally Inserted Central Venous Catheters

2008 ◽  
Vol 29 (3) ◽  
pp. 243-249 ◽  
Author(s):  
Jeffery S. Garland ◽  
Colleen P. Alex ◽  
Jackie M. Sevallius ◽  
Dawn M. Murphy ◽  
Mary J. Good ◽  
...  
Keyword(s):  
Cohort Study ◽  
Bloodstream Infection ◽  
Neonatal Intensive Care ◽  
Insertion Site ◽  
Central Venous Catheters ◽  
Central Venous ◽  
Coagulase Negative Staphylococci ◽  
Pulsed Field Electrophoresis ◽  
Catheter Tip ◽  
Catheter Related Bloodstream Infection

Objective.To better define the pathogenesis of catheter-related bloodstream infection (BSI) in neonates with peripherally inserted central venous catheters (PICCs) to guide the development of more effective strategies for prevention.Design.Prospective nested cohort study.Setting.Level III neonatal intensive care unit in a community hospital.Methods.During a randomized trial to assess the safety and efficacy of a prophylactic vancomycin-heparin catheter-lock solution for the prevention of catheter-related BSI in neonates with PICCs, we performed cultures of peripheral and catheter-drawn blood samples, and quantitative cultures of catheter hub samples if BSI was suspected clinically. We performed semiquantitative cultures of the catheter tip and the catheter hub and the skin at the insertion site when the catheter was removed. Molecular subtyping by pulsed-field electrophoresis was used to determine the probable pathogenesis of all BSIs due to coagulase-negative staphylococci (CoNS); for BSIs caused by other microorganisms, epidemiologic concordance was based on speciation and antibiograms. Catheter-related BSI was considered extraluminally acquired if concordance was demonstrable solely between isolates recovered from the catheter tip and the blood, independent of concordance with isolates recovered from the insertion site. Catheter-related BSI was considered intraluminally acquired if concordance was demonstrated only between isolates recovered from the catheter hub and the blood. The source of the infection was considered indeterminate if both concordance patterns were present.Results.Nosocomial BSI was identified in 23 of the 82 neonates in the cohort. Fifteen of these infections, 14 of which were caused by CoNS, were considered definite or probable catheter-related BSIs. Catheter-related BSI was intraluminally acquired in 10 (67%) of 15 patients, extraluminally acquired in 3 (20%), and indeterminate in 2 (13%).Conclusions.Most catheter-related BSIs in neonates with PICCs are caused by CoNS and derive from intraluminal contamination. Strategies for prevention of catheter-related BSI directed at this predominant mechanism of infection are most likely to be effective.

Risk Factors for Central Venous Catheter–Associated Bloodstream Infection in Pediatric Patients: A Cohort Study

2016 ◽  
Vol 37 (8) ◽  
pp. 939-945 ◽  
Author(s):  
Jillian Hansen Carter ◽  
Joanne Marie Langley ◽  
Stefan Kuhle ◽  
Susan Kirkland
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Hand Hygiene ◽  
Bloodstream Infection ◽  
Tertiary Care ◽  
Cox Proportional Hazards ◽  
Infection Prevention And Control ◽  
Temporal Association ◽  
Central Venous ◽  
Over Time

OBJECTIVETo examine the incidence of central-line–associated bloodstream infection (CLABSI) over time and to determine risk factors for CLABSI in hospitalized children.DESIGNProspective cohort study.SETTINGPediatric tertiary care referral center in Halifax, Nova Scotia, serving a population of 2.3 million.PARTICIPANTSPatients ages 0–18 years with central venous catheters (CVCs) inserted at this facility between 1995 and 2013.METHODSParticipants were followed from CVC insertion to CLABSI event or until CVC removal. Data were prospectively collected by clinicians, infection prevention and control staff, and nursing staff for the purposes of patient care, surveillance, and quality improvement. Cox proportional hazards regression was used to identify risk factors for CLABSI.RESULTSAmong 5,648 patients, 385 developed CLABSI (0.74 CLABSI per 1,000 line days; or 3.87 per 1,000 in-hospital line days). Most infections occurred within 60 days of insertion. CLABSI rates decreased from 4.87 per 1,000 in-hospital line days in 1995 to 0.78 per 1,000 in-hospital line days in 2013, corresponding to an 84% reduction. A temporal association of CLABSI reduction with a hand hygiene promotion campaign was identified. CVC type, number of lumens, dressing type, insertion vein, and being in the critical care unit were statistically significantly associated with CLABSI.CONCLUSIONSHospital-wide surveillance over an 18-year period identified children at highest risk for CLABSI and decreasing risk over time; this decrease was temporally associated with a hand hygiene campaign.Infect Control Hosp Epidemiol 2016;37:939–945

Prospective Incidence Study of Bloodstream Infection in Infants and Children With Central Venous Catheters After Cardiac Surgery in Italy

2009 ◽  
Vol 30 (7) ◽  
pp. 698-701 ◽  
Author(s):  
Stefania Bezzio ◽  
C. Scolfaro ◽  
R. Broglia ◽  
R. Calabrese ◽  
F. Mignone ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiac Surgery ◽  
Observational Study ◽  
Bloodstream Infection ◽  
Medical Staff ◽  
Prospective Observational Study ◽  
Central Venous Catheters ◽  
Central Venous ◽  
In Infants And Children ◽  
Catheter Related Bloodstream Infection

This prospective observational study was designed to assess the incidence of, risk factors for, and outcome of catheter-related bloodstream infection in children undergoing cardiac surgery. A staff specifically trained to handle the central venous catheters with proper aseptic techniques and an appropriate patient to medical staff ratio remain the most effective measures to prevent this infection.

scholarly journals Genotypic study documents divergence in the pathogenesis of bloodstream infection related central venous catheters in neonates

2014 ◽  
Vol 18 (4) ◽  
pp. 387-393 ◽  
Author(s):  
Cristiane Silveira Brito ◽  
Rosineide Marques Ribas ◽  
Daiane Silva Resende ◽  
Denise Von Dolinger de Brito ◽  
Vânia Olivetti Steffen Abdallah ◽  
...  
Keyword(s):  
Bloodstream Infection ◽  
Central Venous Catheters ◽  
Central Venous
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