scholarly journals Surfactant Protein D as a Potential Biomarker and Therapeutic Target in Ovarian Cancer

2019 ◽  
Vol 9 ◽  
Author(s):  
Juhi Kumar ◽  
Valamarthy Murugaiah ◽  
Georgios Sotiriadis ◽  
Anuvinder Kaur ◽  
Jeyarooban Jeyaneethi ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Therapeutic Target ◽  
Surfactant Protein ◽  
Surfactant Protein D ◽  
Potential Biomarker

WASF2 Serves as a Potential Biomarker and Therapeutic Target in Ovarian Cancer: A Pan-Cancer Analysis

2021 ◽  
Author(s):  
Xiaofeng Yang ◽  
Yuzhen Ding ◽  
Lu Sun ◽  
Meiting Shi ◽  
Ping Zhang ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Therapeutic Target ◽  
Potential Biomarker ◽  
Pan Cancer

scholarly journals LPA3 is a precise therapeutic target and potential biomarker for ovarian cancer

2022 ◽  
Vol 39 (2) ◽  
Author(s):  
Pengfei Zhao ◽  
Qingru Yun ◽  
Aodungerile Li ◽  
Rong Li ◽  
Yali Yan ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Therapeutic Target ◽  
Potential Biomarker

Serum surfactant protein D is a potential biomarker of lung damage in systemic sclerosis

2016 ◽  
Author(s):  
Riccardo Messina ◽  
Alida Benfante ◽  
Daniela Castiglia ◽  
Claudia I. Gruttad'Auria ◽  
Nicola Scichilone
Keyword(s):  
Systemic Sclerosis ◽  
Surfactant Protein ◽  
Lung Damage ◽  
Surfactant Protein D ◽  
Potential Biomarker

scholarly journals Plasma surfactant protein-D as a potential biomarker in idiopathic pulmonary fibrosis

2019 ◽  
Vol 13 (2) ◽  
pp. 214 ◽  
Author(s):  
YasmineH El Hinnawy ◽  
MohamedA El Nady ◽  
SafyZ Kaddah ◽  
Radwa M.A Halim ◽  
RehamH Kandeel
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Surfactant Protein ◽  
Surfactant Protein D ◽  
Potential Biomarker

LPA3 Is a Precise Therapeutic Target And Potential Biomarker For Ovarian Cancer

2021 ◽  
Author(s):  
Pengfei Zhao ◽  
Qingru Yun ◽  
Aodungerile Li ◽  
Rong Li ◽  
Yali Yan ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Therapeutic Target ◽  
Bioinformatic Analysis ◽  
Ovarian Cancer Cells ◽  
Cancer Tissue ◽  
Lpa Receptor ◽  
Ovarian Cancer Tissue ◽  
Potential Biomarker

Abstract Current studies have demonstrated that significant increased LPA levels to be observed in ascites in patients with ovarian cancer. Although several studies have shown that Lysophosphatidic acid (LPA) related to the progression of ovarian cancer, which LPA receptors (LPARs) and G coupled protein subtypes mediated in LPA actions have not been clearly elucidated. This study aimed to clarify the roles of LPA and it’s subtype-specific LPARs mediating mechanisms in ovarian cancer by integrated using bioinformatic analysis and biological experimental approaches. The big data analysis shown that LPA3 was the only differentially expressed LPA receptor among the six LPARs in ovarian cancer and further verified in immunohistochemistry of tissue microarrays. Also found that LPA3 was also highly expressed in ovarian cancer tissue and ovarian cancer cells. Importantly, LPA significantly promoted the proliferation and migration of LPA3-overexpressing ovarian cancer cells, while the LPA-induced actions blocked by Ki16425, a LPAR1/3 antagonist treated, and LPA3-shRNA transfected. In vivo study indicated that the LPA3-overexpressing cell derived tumors metastasis, tumors volume and tumors mass were apparently increased in xenografted nude mice. In addition, we also observed that LPA3 was differential high-expression in ovarian cancer tissue of the patients. Our studies further confirmed the LPA3/Gi/MAPKs/NF-κB signals were involved in LPA-induced oncogenic actions in ovarian cancer cells. Our findings indicated that the LPA3 might be a novel precise therapeutic target and potential biomarker for ovarian cancer.

scholarly journals SLC7A2 serves as a potential biomarker and therapeutic target for ovarian cancer

Aging ◽  
2020 ◽  
Vol 12 (13) ◽  
pp. 13281-13296 ◽  
Author(s):  
Tianshui Sun ◽  
Fangfang Bi ◽  
Zhuonan Liu ◽  
Qing Yang
Keyword(s):  
Ovarian Cancer ◽  
Therapeutic Target ◽  
Potential Biomarker

scholarly journals Surfactant Protein-D (SP-D): a Potential Therapeutic Target for Seasonal Allergic Rhinitis

2017 ◽  
Vol 139 (2) ◽  
pp. AB84
Author(s):  
Iesha Singh ◽  
Asif Qaseem ◽  
Ansar Pathan ◽  
Rebecca Parkin ◽  
Uday Kishore ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Therapeutic Target ◽  
Seasonal Allergic Rhinitis ◽  
Surfactant Protein ◽  
Surfactant Protein D ◽  
Potential Therapeutic Target
Sign in / Sign up

Export Citation Format

Share Document