A Characterization of Amiodarone-Induced Pulmonary Toxicity in F344 Rats and Identification of Surfactant Protein-D as a Potential Biomarker for the Development of the Toxicity

2000 ◽  
Vol 167 (3) ◽  
pp. 182-190 ◽  
Author(s):  
Michael D. Taylor ◽  
Knox Van Dyke ◽  
Linda L. Bowman ◽  
Philip R. Miles ◽  
Ann F. Hubbs ◽  
...  
Keyword(s):  
Pulmonary Toxicity ◽  
Surfactant Protein ◽  
Surfactant Protein D ◽  
Potential Biomarker ◽  
F344 Rats

scholarly journals Identification and Characterization of a Novel Interaction between Pulmonary Surfactant Protein D and Decorin

2003 ◽  
Vol 278 (28) ◽  
pp. 25678-25687 ◽  
Author(s):  
Jeya Nadesalingam ◽  
Andrés López Bernal ◽  
Alister W. Dodds ◽  
Antony C. Willis ◽  
David J. Mahoney ◽  
...  
Keyword(s):  
Pulmonary Surfactant ◽  
Surfactant Protein ◽  
Surfactant Protein D ◽  
Identification And Characterization ◽  
Pulmonary Surfactant Protein

Bovine conglutinin (BC) mRNA expressed in liver: cloning and characterization of the BC cDNA reveals strong homology to surfactant protein-D

Gene ◽  
1994 ◽  
Vol 141 (2) ◽  
pp. 277-281 ◽  
Author(s):  
Louis S Liou ◽  
Rajeswari Sastry ◽  
Kevan L Hartshorn ◽  
Young Moo Lee ◽  
Thomas B Okarma ◽  
...  
Keyword(s):  
Surfactant Protein ◽  
Surfactant Protein D ◽  
Strong Homology

Serum surfactant protein D is a potential biomarker of lung damage in systemic sclerosis

2016 ◽  
Author(s):  
Riccardo Messina ◽  
Alida Benfante ◽  
Daniela Castiglia ◽  
Claudia I. Gruttad'Auria ◽  
Nicola Scichilone
Keyword(s):  
Systemic Sclerosis ◽  
Surfactant Protein ◽  
Lung Damage ◽  
Surfactant Protein D ◽  
Potential Biomarker

scholarly journals Plasma surfactant protein-D as a potential biomarker in idiopathic pulmonary fibrosis

2019 ◽  
Vol 13 (2) ◽  
pp. 214 ◽  
Author(s):  
YasmineH El Hinnawy ◽  
MohamedA El Nady ◽  
SafyZ Kaddah ◽  
Radwa M.A Halim ◽  
RehamH Kandeel
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Surfactant Protein ◽  
Surfactant Protein D ◽  
Potential Biomarker

Genomic and molecular characterization of bovine surfactant protein D (SP-D)1

2004 ◽  
Vol 41 (4) ◽  
pp. 369-376 ◽  
Author(s):  
M GJERSTORFF ◽  
J MADSEN ◽  
C BENDIXEN ◽  
U HOLMSKOV ◽  
S HANSEN
Keyword(s):  
Molecular Characterization ◽  
Surfactant Protein ◽  
Surfactant Protein D

Characterization of pulmonary surfactant protein D: its copurification with lipids

1991 ◽  
Vol 1086 (2) ◽  
pp. 185-190 ◽  
Author(s):  
Yoshio Kuroki ◽  
Masanori Shiratori ◽  
Yoshinori Ogasawara ◽  
Akihiro Tsuzuki ◽  
Toyoaki Akino
Keyword(s):  
Pulmonary Surfactant ◽  
Surfactant Protein ◽  
Surfactant Protein D ◽  
Pulmonary Surfactant Protein

scholarly journals Examination of Surfactant Protein D as a Biomarker for Evaluating Pulmonary Toxicity of Nanomaterials in Rat

2021 ◽  
Vol 22 (9) ◽  
pp. 4635
Author(s):  
Taisuke Tomonaga ◽  
Hiroto Izumi ◽  
Yukiko Yoshiura ◽  
Chinatsu Nishida ◽  
Kazuhiro Yatera ◽  
...  
Keyword(s):  
Lung Inflammation ◽  
Pulmonary Toxicity ◽  
Intratracheal Instillation ◽  
Lavage Fluid ◽  
Surfactant Protein ◽  
Surfactant Protein D ◽  
Operating Characteristics ◽  
Low Toxicity ◽  
Titanium Dioxides ◽  
The Relationship

This work studies the relationship between lung inflammation caused by nanomaterials and surfactant protein D (SP-D) kinetics and investigates whether SP-D can be a biomarker of the pulmonary toxicity of nanomaterials. Nanomaterials of nickel oxide and cerium dioxide were classified as having high toxicity, nanomaterials of two types of titanium dioxides and zinc oxide were classified as having low toxicity, and rat biological samples obtained from 3 days to 6 months after intratracheal instillation of those nanomaterials and micron-particles of crystalline silica were used. There were different tendencies of increase between the high- and low-toxicity materials in the concentration of SP-D in bronchoalveolar-lavage fluid (BALF) and serum and in the expression of the SP-D gene in the lung tissue. An analysis of the receiver operating characteristics for the toxicity of the nanomaterials by SP-D in BALF and serum showed a high accuracy of discrimination from 1 week to 3 or 6 months after exposure. These data suggest that the differences in the expression of SP-D in BALF and serum depended on the level of lung inflammation caused by the nanomaterials and that SP-D can be biomarkers for evaluating the pulmonary toxicity of nanomaterials.

Sign in / Sign up

Export Citation Format

Share Document