Serum Surfactant Protein D is a Potential Biomarker of Decline in Lung Function and COPD: A Prospective Pilot Study

CHEST Journal ◽  
2016 ◽  
Vol 149 (4) ◽  
pp. A385
Author(s):  
Jiping Liao ◽  
Xi Wang ◽  
Cheng Yuan ◽  
Yanni Zhao ◽  
Guangfa Wang
Keyword(s):  
Pilot Study ◽  
Lung Function ◽  
Surfactant Protein ◽  
Surfactant Protein D ◽  
Prospective Pilot Study ◽  
Potential Biomarker

Surfactant protein D as a marker for pulmonary complications in pediatric patients with sickle cell disease: Relation to lung function tests

2019 ◽  
Vol 54 (5) ◽  
pp. 610-619 ◽  
Author(s):  
Azza A. Tantawy ◽  
Amira A. Adly ◽  
Fatma S. E. Ebeid ◽  
Eman A. Ismail ◽  
Mahitab M. Hussein ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Lung Function ◽  
Sickle Cell ◽  
Pediatric Patients ◽  
Surfactant Protein ◽  
Pulmonary Complications ◽  
Surfactant Protein D ◽  
Lung Function Tests ◽  
Cell Disease ◽  
Function Tests

MMP-7 a potential biomarker of invasive cervix cancer: A prospective pilot study.

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. e17005-e17005 ◽  
Author(s):  
David Mysona ◽  
Adam Pyrzak ◽  
Jennifer Allen ◽  
Shan Bai ◽  
Ashok Sharma ◽  
...  
Keyword(s):  
Pilot Study ◽  
Cervix Cancer ◽  
Prospective Pilot Study ◽  
Potential Biomarker

Increased serum SP-D in identification of high-risk smokers at high risk of COPD

2021 ◽  
Author(s):  
Christine Dalgård ◽  
Fang Wang ◽  
Ingrid Louise Titlestad ◽  
Kirsten Ohm Kyvik ◽  
Jørgen Vestbo ◽  
...  
Keyword(s):  
High Risk ◽  
Lung Function ◽  
Surfactant Protein ◽  
Innate Immune ◽  
Normal Lung ◽  
Surfactant Protein D ◽  
Lung Function Decline ◽  
Normal Lung Function ◽  
Danish Twin

Pulmonary surfactant protein D (SP-D) is an important component of the pulmonary innate immune system with the ability to dampen cigarette smoke-induced lung inflammation. However, cigarette smoking mediates translocation of SP-D from the lung to the blood, and serum SP-D (sSP-D) has therefore previously been suggested as marker for smoke-induced lung injury. In support of this notion, associations between high sSP-D and low lung function measurements have previously been demonstrated in smokers and in COPD. The present investigations employ a 12-year longitudinal Danish twin study to test the hypothesis that baseline sSP-D variation has the capacity to identify smokers with normal baseline lung function who are in high risk of significant future smoke-induced lung function decline. We find that sSP-D is significantly increased in those with normal lung function at baseline that develop lung function decline during follow up compared to those who stay lung healthy. Moreover, we demonstrate that it is the smoke-induced baseline sSP-D level, and not the constitutional level, which has capacity as biomarker, and which is linearly increased with the decline in lung function during follow up. In conclusion, we here present first observation of increased sSP-D for identification of high-risk smokers.

Serum surfactant protein D is a potential biomarker of lung damage in systemic sclerosis

2016 ◽  
Author(s):  
Riccardo Messina ◽  
Alida Benfante ◽  
Daniela Castiglia ◽  
Claudia I. Gruttad'Auria ◽  
Nicola Scichilone
Keyword(s):  
Systemic Sclerosis ◽  
Surfactant Protein ◽  
Lung Damage ◽  
Surfactant Protein D ◽  
Potential Biomarker

scholarly journals Surfactant protein D is a candidate biomarker for subclinical tobacco smoke-induced lung damage

2014 ◽  
Vol 306 (9) ◽  
pp. L887-L895 ◽  
Author(s):  
Sofie L. Johansson ◽  
Qihua Tan ◽  
René Holst ◽  
Lene Christiansen ◽  
Niels C. G. Hansen ◽  
...  
Keyword(s):  
Lung Function ◽  
Single Nucleotide Polymorphisms ◽  
Tobacco Smoke ◽  
Tobacco Smoking ◽  
Surfactant Protein ◽  
Lung Damage ◽  
Surfactant Protein D ◽  
Chronic Obstructive ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide

Variation in surfactant protein D (SP-D) is associated with lung function in tobacco smoke-induced chronic respiratory disease. We hypothesized that the same association exists in the general population and could be used to identify individuals sensitive to smoke-induced lung damage. The association between serum SP-D (sSP-D) and expiratory lung function was assessed in a cross-sectional design in a Danish twin population ( n = 1,512, 18–72 yr old). The adjusted heritability estimates for expiratory lung function, associations between SP-D gene ( SFTPD) single-nucleotide polymorphisms or haplotypes, and expiratory lung function were assessed using twin study methodology and mixed-effects models. Significant inverse associations were evident between sSP-D and the forced expiratory volume in 1 s and forced vital capacity in the presence of current tobacco smoking but not in nonsmokers. The two SFTPD single-nucleotide polymorphisms, rs1923536 and rs721917, and haplotypes, including these single-nucleotide polymorphisms or rs2243539, were inversely associated with expiratory lung function in interaction with smoking. In conclusion, SP-D is phenotypically and genetically associated with lung function measures in interaction with tobacco smoking. The obtained data suggest sSP-D as a candidate biomarker in risk assessments for subclinical tobacco smoke-induced lung damage. The data and derived conclusion warrant confirmation in a longitudinal population following chronic obstructive pulmonary disease initiation and development.

scholarly journals Plasma surfactant protein-D as a potential biomarker in idiopathic pulmonary fibrosis

2019 ◽  
Vol 13 (2) ◽  
pp. 214 ◽  
Author(s):  
YasmineH El Hinnawy ◽  
MohamedA El Nady ◽  
SafyZ Kaddah ◽  
Radwa M.A Halim ◽  
RehamH Kandeel
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Surfactant Protein ◽  
Surfactant Protein D ◽  
Potential Biomarker
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