scholarly journals A Novel Heterocyclic Compound CE-104 Enhances Spatial Working Memory in the Radial Arm Maze in Rats and Modulates the Dopaminergic System

2016 ◽  
Vol 10 ◽  
Author(s):  
Yogesh D. Aher ◽  
Saraswathi Subramaniyan ◽  
Bharanidharan Shanmugasundaram ◽  
Ajinkya Sase ◽  
Sivaprakasam R. Saroja ◽  
...  
Keyword(s):  
Working Memory ◽  
Heterocyclic Compound ◽  
Dopaminergic System ◽  
Spatial Working Memory ◽  
Radial Arm Maze

scholarly journals Dorsal Hippocampus Not Always Necessary in a Radial Arm Maze Delayed Win-shift Task

2018 ◽  
Author(s):  
Dylan Layfield ◽  
Nathan Sidell ◽  
Afnan Abdullahi ◽  
Ehren L. Newman
Keyword(s):  
Working Memory ◽  
Test Performance ◽  
Spatial Working Memory ◽  
Dorsal Hippocampus ◽  
Radial Arm Maze ◽  
Spatial Coding ◽  
Shift Task ◽  
Neural Underpinnings ◽  
Retention Intervals ◽  
Phosphate Buffered Saline

AbstractSpatial working memory is important for foraging and navigating the environment. However, its neural underpinnings remain poorly understood. The hippocampus, known for its spatial coding and involvement in spatial memory, is widely understood to be necessary for spatial working memory when retention intervals increase beyond seconds into minutes. Here, we describe new evidence that the dorsal hippocampus is not always necessary for spatial working memory for retention intervals of 8 minutes. Rats were trained to perform a delayed spatial win shift radial arm maze task (DSWS) with an 8-minute delay between study and test phases. We then tested whether bilateral inactivation of the dorsal hippocampus between the study and test phases impaired behavioral performance at test. Inactivation was achieved through a bilateral infusion of lidocaine. Performance following lidocaine was compared to control trials, in which, sterile phosphate buffered saline (PBS) was infused. Test performance did not differ between the lidocaine and PBS conditions, remaining high in each. To explore the possibility that this insensitivity to inactivation was a result of overtraining, a second cohort of animals received substantially less training prior to the infusions. In this second cohort, lidocaine infusions did significantly impair task performance. These data indicate that successful performance of a spatial win-shift task on the 8-arm maze need not always be hippocampally dependent.

scholarly journals Where Have I Been? Where Should I Go? Spatial Working Memory on a Radial Arm Maze in a Rat Model of Depression

PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e62458 ◽  
Author(s):  
Sophie Helene Richter ◽  
Benjamin Zeuch ◽  
Katja Lankisch ◽  
Peter Gass ◽  
Daniel Durstewitz ◽  
...  
Keyword(s):  
Working Memory ◽  
Rat Model ◽  
Spatial Working Memory ◽  
Radial Arm Maze

A novel heterocyclic compound improves working memory in the radial arm maze and modulates the dopamine receptor D1R in frontal cortex of the Sprague-Dawley rat

2017 ◽  
Vol 332 ◽  
pp. 308-315 ◽  
Author(s):  
Ahmed M. Hussein ◽  
Yogesh D. Aher ◽  
Predrag Kalaba ◽  
Nilima Y. Aher ◽  
Vladimir Dragačević ◽  
...  
Keyword(s):  
Working Memory ◽  
Frontal Cortex ◽  
Dopamine Receptor ◽  
Heterocyclic Compound ◽  
Radial Arm Maze ◽  
Sprague Dawley ◽  
Sprague Dawley Rat

scholarly journals Effect of acute pesticide exposure on bee spatial working memory using an analogue of the radial-arm maze

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Elizabeth E. W. Samuelson ◽  
Zachary P. Chen-Wishart ◽  
Richard J. Gill ◽  
Ellouise Leadbeater
Keyword(s):  
Working Memory ◽  
Pesticide Exposure ◽  
Spatial Working Memory ◽  
Radial Arm Maze

Working Memory and Number Sense as Predictors of Mathematical (Dis-)Ability

2015 ◽  
Vol 223 (2) ◽  
pp. 102-109 ◽  
Author(s):  
Evelyn H. Kroesbergen ◽  
Marloes van Dijk
Keyword(s):  
Working Memory ◽  
Learning Disabilities ◽  
Spatial Working Memory ◽  
Number Sense ◽  
Mathematical Learning ◽  
Visual Spatial ◽  
Mathematical Learning Disabilities ◽  
Visual Spatial Working Memory ◽  
And Mathematics

Recent research has pointed to two possible causes of mathematical (dis-)ability: working memory and number sense, although only few studies have compared the relations between working memory and mathematics and between number sense and mathematics. In this study, both constructs were studied in relation to mathematics in general, and to mathematical learning disabilities (MLD) in particular. The sample consisted of 154 children aged between 6 and 10 years, including 26 children with MLD. Children performing low on either number sense or visual-spatial working memory scored lower on math tests than children without such a weakness. Children with a double weakness scored the lowest. These results confirm the important role of both visual-spatial working memory and number sense in mathematical development.

Glucose Effects on Spatial Working Memory are Dose and Delay Specific

1999 ◽  
Author(s):  
Jarod N. Wright ◽  
Clint D. Walker ◽  
Russell E. Morgan
Keyword(s):  
Working Memory ◽  
Spatial Working Memory ◽  
Glucose Effects

Effects of Oxybutynin Hydrochloride on Working Memory in the Radial-Arm Maze

2000 ◽  
Author(s):  
Renee A. Countryman ◽  
Malinda A. Harris ◽  
Russell E. Morgan
Keyword(s):  
Working Memory ◽  
Radial Arm Maze ◽  
Oxybutynin Hydrochloride

Spatial Working Memory Deficit in Autism

2003 ◽  
Author(s):  
Shelly D. Steele ◽  
Nancy J. Minshew ◽  
Bea Luna ◽  
John A. Sweeney
Keyword(s):  
Working Memory ◽  
Spatial Working Memory ◽  
Memory Deficit
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