Effects of Oxybutynin Hydrochloride on Working Memory in the Radial-Arm Maze

2000 ◽  
Author(s):  
Renee A. Countryman ◽  
Malinda A. Harris ◽  
Russell E. Morgan
Keyword(s):  
Working Memory ◽  
Radial Arm Maze ◽  
Oxybutynin Hydrochloride

scholarly journals Thalamic–Cortical–Striatal Circuitry Subserves Working Memory during Delayed Responding on a Radial Arm Maze

1999 ◽  
Vol 19 (24) ◽  
pp. 11061-11071 ◽  
Author(s):  
Stan B. Floresco ◽  
Deanna N. Braaksma ◽  
Anthony G. Phillips
Keyword(s):  
Working Memory ◽  
Radial Arm Maze

scholarly journals Dorsal Hippocampus Not Always Necessary in a Radial Arm Maze Delayed Win-shift Task

2018 ◽  
Author(s):  
Dylan Layfield ◽  
Nathan Sidell ◽  
Afnan Abdullahi ◽  
Ehren L. Newman
Keyword(s):  
Working Memory ◽  
Test Performance ◽  
Spatial Working Memory ◽  
Dorsal Hippocampus ◽  
Radial Arm Maze ◽  
Spatial Coding ◽  
Shift Task ◽  
Neural Underpinnings ◽  
Retention Intervals ◽  
Phosphate Buffered Saline

AbstractSpatial working memory is important for foraging and navigating the environment. However, its neural underpinnings remain poorly understood. The hippocampus, known for its spatial coding and involvement in spatial memory, is widely understood to be necessary for spatial working memory when retention intervals increase beyond seconds into minutes. Here, we describe new evidence that the dorsal hippocampus is not always necessary for spatial working memory for retention intervals of 8 minutes. Rats were trained to perform a delayed spatial win shift radial arm maze task (DSWS) with an 8-minute delay between study and test phases. We then tested whether bilateral inactivation of the dorsal hippocampus between the study and test phases impaired behavioral performance at test. Inactivation was achieved through a bilateral infusion of lidocaine. Performance following lidocaine was compared to control trials, in which, sterile phosphate buffered saline (PBS) was infused. Test performance did not differ between the lidocaine and PBS conditions, remaining high in each. To explore the possibility that this insensitivity to inactivation was a result of overtraining, a second cohort of animals received substantially less training prior to the infusions. In this second cohort, lidocaine infusions did significantly impair task performance. These data indicate that successful performance of a spatial win-shift task on the 8-arm maze need not always be hippocampally dependent.

scholarly journals Lobeline Effects on Cognitive Performance in Adult ADHD

2013 ◽  
Vol 22 (14) ◽  
pp. 1361-1366 ◽  
Author(s):  
Catherine A. Martin ◽  
Paul A. Nuzzo ◽  
John D. Ranseen ◽  
Mark S. Kleven ◽  
Greg Guenthner ◽  
...  
Keyword(s):  
Working Memory ◽  
Water Maze ◽  
Adult Adhd ◽  
Self Report ◽  
Cognitive Tasks ◽  
Radial Arm Maze ◽  
Preclinical Studies ◽  
Proof Of Concept ◽  
Adverse Side Effects ◽  
Improved Performance

Objective: In preclinical studies, lobeline inhibited hyperactivity induced by nicotine and amphetamine, and improved performance and learning in studies utilizing radial-arm maze and spatial-discrimination water maze. This laboratory proof-of-concept study investigated lobeline as a treatment for ADHD symptoms in adults (31.11 ± 7.08 years). Method: Using cognitive tasks and self-report measures, the effects of lobeline (0, 7.5, 15, or 30 mg, s.l.) and methylphenidate (0, 15, or 30 mg, p.o.) were assessed in nine volunteers with ADHD. Results: Evidence suggested that lobeline could modestly improve working memory in adults with ADHD, but no significant improvement in attention was observed. Lobeline administration was associated with mild adverse side effects (nausea). Conclusion: Further investigation of lobeline on working memory may be warranted.

Bridged nicotine, isonicotine, and norisonicotine effects on working memory performance of rats in the radial-arm maze

1999 ◽  
Vol 46 (2) ◽  
pp. 107-111 ◽  
Author(s):  
Edward D. Levin ◽  
M. Imad Damaj ◽  
William Glassco ◽  
Everett L. May ◽  
Billy R. Martin
Keyword(s):  
Working Memory ◽  
Memory Performance ◽  
Radial Arm Maze

scholarly journals Where Have I Been? Where Should I Go? Spatial Working Memory on a Radial Arm Maze in a Rat Model of Depression

PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e62458 ◽  
Author(s):  
Sophie Helene Richter ◽  
Benjamin Zeuch ◽  
Katja Lankisch ◽  
Peter Gass ◽  
Daniel Durstewitz ◽  
...  
Keyword(s):  
Working Memory ◽  
Rat Model ◽  
Spatial Working Memory ◽  
Radial Arm Maze

Septal serotonin depletion in rats facilitates working memory in the radial arm maze and increases hippocampal high-frequency theta activity

2014 ◽  
Vol 734 ◽  
pp. 105-113 ◽  
Author(s):  
Miguel Ángel López-Vázquez ◽  
Elisa López-Loeza ◽  
Naima Lajud Ávila ◽  
Blanca Erika Gutiérrez-Guzmán ◽  
J. Jesús Hernández-Pérez ◽  
...  
Keyword(s):  
Working Memory ◽  
High Frequency ◽  
Theta Activity ◽  
Radial Arm Maze ◽  
Serotonin Depletion

A novel heterocyclic compound improves working memory in the radial arm maze and modulates the dopamine receptor D1R in frontal cortex of the Sprague-Dawley rat

2017 ◽  
Vol 332 ◽  
pp. 308-315 ◽  
Author(s):  
Ahmed M. Hussein ◽  
Yogesh D. Aher ◽  
Predrag Kalaba ◽  
Nilima Y. Aher ◽  
Vladimir Dragačević ◽  
...  
Keyword(s):  
Working Memory ◽  
Frontal Cortex ◽  
Dopamine Receptor ◽  
Heterocyclic Compound ◽  
Radial Arm Maze ◽  
Sprague Dawley ◽  
Sprague Dawley Rat
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