scholarly journals Unique genetic loci identified for emotional behavior in control and chronic stress conditions

2014 ◽  
Vol 8 ◽  
Author(s):  
Kimberly A. K. Carhuatanta ◽  
Chloe J. A. Shea ◽  
James P. Herman ◽  
Ryan Jankord
Keyword(s):  
Chronic Stress ◽  
Emotional Behavior ◽  
Stress Conditions ◽  
Genetic Loci

scholarly journals Sex-dependent regulation of hippocampal neurogenesis under basal and chronic stress conditions in rats

Hippocampus ◽  
2013 ◽  
Vol 23 (6) ◽  
pp. 476-487 ◽  
Author(s):  
Katharina M. Hillerer ◽  
Inga D. Neumann ◽  
Sebastien Couillard-Despres ◽  
Ludwig Aigner ◽  
David A. Slattery
Keyword(s):  
Chronic Stress ◽  
Hippocampal Neurogenesis ◽  
Stress Conditions

scholarly journals Amygdala NPY Circuits Promote the Development of Accelerated Obesity under Chronic Stress Conditions

2019 ◽  
Vol 30 (1) ◽  
pp. 111-128.e6 ◽  
Author(s):  
Chi Kin Ip ◽  
Lei Zhang ◽  
Aitak Farzi ◽  
Yue Qi ◽  
Ireni Clarke ◽  
...  
Keyword(s):  
Chronic Stress ◽  
Stress Conditions

scholarly journals Role of α7- and α4β2-nAChRs in the neuroprotective effect of nicotine in stress-induced impairment of hippocampus-dependent memory

2013 ◽  
Vol 16 (5) ◽  
pp. 1105-1113 ◽  
Author(s):  
Karem H. Alzoubi ◽  
Marisa Srivareerat ◽  
Trinh T. Tran ◽  
Karim A. Alkadhi
Keyword(s):  
Chronic Stress ◽  
Nicotinic Acetylcholine Receptors ◽  
Acetylcholine Receptors ◽  
Short Term Memory ◽  
Neuroprotective Effect ◽  
Stress Conditions ◽  
Nicotine Treatment ◽  
Memory Tests ◽  
Α7 Nachrs

Abstract We have previously shown that nicotine prevents stress-induced memory impairment. In this study, we have investigated the role of α7- and α4β2-nicotinic acetylcholine receptors (nAChRs) in the protective effect of nicotine during chronic stress conditions. Chronic psychosocial stress was induced using a form of rat intruder model. During stress, specific antagonist for either α7-nAChRs [methyllycaconitine (MLA)] or α4β2-nAChRs [dihydro-β-erythroidine (DHβE)] was infused into the hippocampus using a 4-wk osmotic pump at a rate of 82 µg/side.d and 41 µg/side.d, respectively. Three weeks after the start of infusion, all rats were subjected to a series of cognitive tests in the radial arm water maze (RAWM) for six consecutive days or until the animal reached days to criterion (DTC) in the fourth acquisition trial and in all memory tests. DTC is defined as the number of days the animal takes to make no more than one error in three consecutive days. In the short-term memory test, MLA-infused stressed/nicotine-treated rats made similar errors to those of stress and significantly more errors compared to those of stress/nicotine, nicotine or control groups. This finding was supported by the DTC values for the short memory tests. Thus, MLA treatment blocked the neuroprotective effect of nicotine during chronic stress. In contrast, DHβE infusion did not affect the RAWM performance of stress/nicotine animals. These results strongly suggest the involvement of α7-nAChRs, but not α4β2-nAChRs, in the neuroprotective effect of chronic nicotine treatment during chronic stress conditions.

scholarly journals Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Anastasiya Kasian ◽  
Timur Kolomin ◽  
Lyudmila Andreeva ◽  
Elena Bondarenko ◽  
Nikolay Myasoedov ◽  
...  
Keyword(s):  
Chronic Stress ◽  
Anxiolytic Effect ◽  
Chronic Mild Stress ◽  
Stress Conditions ◽  
Mild Stress ◽  
Unpredictable Chronic Mild Stress ◽  
Elevated Plus Maze Test ◽  
Plus Maze ◽  
The Individual ◽  
Benzodiazepine Drugs

It was shown that the anxiolytic effect of Selank is comparable to that of classical benzodiazepine drugs and that the basis of their mechanism of action may be similar. These data suggest that the presence of Selank may change the action of classical benzodiazepine drugs. To test this hypothesis, we evaluated the anxiolytic activity of Selank and diazepam in rats both under conditions of unpredictable chronic mild stress and in its absence, after the individual and combined administration of these compounds using the elevated plus maze test. We found that, even in the absence of chronic stress, the administration of a course of test substances changed anxiety indicators toward their deterioration, but the changes after the administration of a course of Selank were less pronounced. In conditions of chronic stress, anxiety indicator values after the simultaneous use of diazepam and Selank did not differ from the respective values observed before chronic stress exposure. The data obtained indicate that the individual administration of Selank was the most effective in reducing elevated levels of anxiety, induced by the administration of a course of test substances, whereas the combination of diazepam with Selank was the most effective in reducing anxiety in unpredictable chronic mild stress conditions.

scholarly journals Corticosterone mediates the synaptic and behavioral effects of chronic stress at rat hippocampal temporoammonic synapses

2015 ◽  
Vol 114 (3) ◽  
pp. 1713-1724 ◽  
Author(s):  
Mark D. Kvarta ◽  
Keighly E. Bradbrook ◽  
Hannah M. Dantrassy ◽  
Aileen M. Bailey ◽  
Scott M. Thompson
Keyword(s):  
Spatial Memory ◽  
Chronic Stress ◽  
Glutamate Receptor ◽  
Memory Consolidation ◽  
Emotional Processing ◽  
Emotional Behavior ◽  
Synthesis Inhibitor ◽  
Excitatory Strength ◽  
Brain Structure And Function ◽  
And Function

Chronic stress is thought to impart risk for depression via alterations in brain structure and function, but contributions of specific mediators in generating these changes remain unclear. We test the hypothesis that stress-induced increases in corticosterone (CORT), the primary rodent glucocorticoid, are the key mediator of stress-induced depressive-like behavioral changes and synaptic dysfunction in the rat hippocampus. In rats, we correlated changes in cognitive and affective behavioral tasks (spatial memory consolidation, anhedonia, and neohypophagia) with impaired excitatory strength at temporoammonic-CA1 (TA-CA1) synapses, an archetypical stress-sensitive excitatory synapse. We tested whether elevated CORT was sufficient and necessary to generate a depressive-like behavioral phenotype and decreased excitatory signaling observed at TA-CA1 after chronic unpredictable stress (CUS). Chronic CORT administration induced an anhedonia-like behavioral state and neohypophagic behavior. Like CUS, chronic, but not acute, CORT generated an impaired synaptic phenotype characterized by reduced α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-preferring glutamate receptor-mediated excitation at TA-CA1 synapses, decreased AMPA-type glutamate receptor subunit 1 protein expression, and altered serotonin-1B receptor-mediated potentiation. Repeatedly blunting stress-induced increases of CORT during CUS with the CORT synthesis inhibitor metyrapone (MET) prevented these stress-induced neurobehavioral changes. MET also prevented the CUS-induced impairment of spatial memory consolidation. We conclude that corticosterone is sufficient and necessary to mediate glutamatergic dysfunction underlying stress-induced synaptic and behavioral phenotypes. Our results indicate that chronic excessive glucocorticoids cause specific synaptic deficits in the hippocampus, a major center for cognitive and emotional processing, that accompany stress-induced behavioral dysfunction. Maintaining excitatory strength at stress-sensitive synapses at key loci throughout corticomesolimbic reward circuitry appears critical for maintaining normal cognitive and emotional behavior.

scholarly journals Pathophysiology of affective disorders: functional interaction of stress hormones and hippocampal excitation

2017 ◽  
Vol 117 (2) ◽  
pp. 477-479
Author(s):  
M. Adrienne McGinn ◽  
Amanda R. Pahng
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Chronic Stress ◽  
Affective Disorders ◽  
Stress Hormones ◽  
Emotional Behavior ◽  
Hippocampal Function ◽  
Functional Interaction ◽  
Major Depressive ◽  
New Finding

An important new study by Kvarta, Bradbrook, Dantrassy, Bailey, and Thompson ( J Neurophysiol 114: 1713–1724, 2015) examined the effects of persistent stress and excessive glucocorticoid levels on hippocampal function and emotional behavior in rodents. The authors specifically implicate the temporoammonic pathway as being susceptible to reductions in excitatory function in the context of chronic stress. We discuss the importance of this new finding in the broader context of medication development for major depressive disorder.

P.4.012 Behavioural and molecular alterations in FKBP52+/− mice under basal and chronic stress conditions

2012 ◽  
Vol 22 ◽  
pp. S92-S93
Author(s):  
J. Hartmann ◽  
K.V. Wagner ◽  
F. Hausch ◽  
T. Rein ◽  
U. Schmidt ◽  
...  
Keyword(s):  
Chronic Stress ◽  
Stress Conditions ◽  
Molecular Alterations
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