scholarly journals Sex-dependent regulation of hippocampal neurogenesis under basal and chronic stress conditions in rats

Hippocampus ◽  
2013 ◽  
Vol 23 (6) ◽  
pp. 476-487 ◽  
Author(s):  
Katharina M. Hillerer ◽  
Inga D. Neumann ◽  
Sebastien Couillard-Despres ◽  
Ludwig Aigner ◽  
David A. Slattery
Keyword(s):  
Chronic Stress ◽  
Hippocampal Neurogenesis ◽  
Stress Conditions

scholarly journals Selective activation of estrogen receptors α and β: Implications for depressive-like phenotypes in female mice exposed to chronic unpredictable stress

2019 ◽  
Author(s):  
Rand S. Eid ◽  
Stephanie E. Lieblich ◽  
Paula Duarte-Guterman ◽  
Jessica A. Chaiton ◽  
Amanda G. Mah ◽  
...  
Keyword(s):  
Chronic Stress ◽  
Hpa Axis ◽  
Dorsal Hippocampus ◽  
Tail Suspension Test ◽  
Hippocampal Neurogenesis ◽  
Stress Conditions ◽  
Adult Hippocampal Neurogenesis ◽  
Estrogen Signaling ◽  
Chronic Unpredictable Stress ◽  
17Β Estradiol

AbstractThe estrogen receptor (ER) mechanisms by which 17β-estradiol influences depressive-like behaviour have primarily been investigated acutely and not within an animal model of depression. Therefore, the current study aimed to dissect the contribution of ERα and ERβ to the effects of 17β-estradiol under non-stress and chronic stress conditions. Ovariectomized (OVX) or sham-operated mice were treated chronically (47 days) with 17β-estradiol (E2), the ERβ agonist diarylpropionitrile (DPN), the ERα agonist propylpyrazole-triol (PPT), or vehicle. On day 15 of treatment, mice from each group were assigned to Chronic Unpredictable Stress (CUS; 28 days) or non-CUS conditions. Mice were assessed for anxiety- and depressive-like behaviour and hypothalamic-pituitary-adrenal (HPA) axis function. Cytokine and chemokine levels, and postsynaptic density protein 95 were measured in the hippocampus and frontal cortex, and adult hippocampal neurogenesis was assessed. Overall, the effects of CUS were more robust that those of estrogenic treatments, as seen by increased immobility in the tail suspension test (TST), reduced PSD-95 expression, reduced neurogenesis in the ventral hippocampus, and HPA axis negative feedback dysregulation. However, we also observe CUS-dependent and -independent effects of ovarian status and estrogenic treatments. The effects of CUS on PSD-95 expression, the cytokine milieu, and in TST were largely driven by PPT and DPN, indicating that these treatments were not protective. Independent of CUS, estradiol increased neurogenesis in the dorsal hippocampus, blunted the corticosterone response to an acute stressor, but increased anxiety-like behaviour. These findings provide insights into the complexities of estrogen signaling in modulating depressive-like phenotypes under non-stress and chronic stress conditions.

Sexual activity counteracts the suppressive effects of chronic stress on adult hippocampal neurogenesis and recognition memory

2013 ◽  
Vol 1538 ◽  
pp. 26-40 ◽  
Author(s):  
Jong-In Kim ◽  
Jae Won Lee ◽  
Young Ah Lee ◽  
Dong-Hun Lee ◽  
Nam Soo Han ◽  
...  
Keyword(s):  
Recognition Memory ◽  
Sexual Activity ◽  
Chronic Stress ◽  
Hippocampal Neurogenesis ◽  
Adult Hippocampal Neurogenesis

scholarly journals Elimination of Vesicular Zinc Alters the Behavioural and Neuroanatomical Effects of Social Defeat Stress in Mice

2018 ◽  
Author(s):  
Brendan B. McAllister ◽  
David K. Wright ◽  
Ryan C. Wortman ◽  
Sandy R. Shultz ◽  
Richard H. Dyck
Keyword(s):  
Corpus Callosum ◽  
Chronic Stress ◽  
Social Defeat ◽  
Volumetric Analysis ◽  
Hippocampal Neurogenesis ◽  
Wild Type ◽  
Enhanced Sensitivity ◽  
Y Maze ◽  
Genetic Deletion ◽  
Stress Susceptibility

ABSTRACTChronic stress can have deleterious effects on mental health, increasing the risk of developing depression or anxiety. But not all individuals are equally affected by stress; some are susceptible while others are more resilient. Understanding the mechanisms that lead to these differing outcomes has been a focus of considerable research. One unexplored mechanism is vesicular zinc – zinc that is released by neurons as a neuromodulator. We examined how chronic stress, induced by repeated social defeat, affects mice that lack vesicular zinc due to genetic deletion of zinc transporter 3 (ZnT3). These mice, unlike wild type mice, did not become socially avoidant of a novel conspecific, suggesting resilience to stress. However, they showed enhanced sensitivity to the potentiating effect of stress on cued fear memory. Thus, the contribution of vesicular zinc to stress susceptibility is not straightforward. Stress also increased anxiety-like behaviour but produced no deficits in a spatial Y-maze test. We found no evidence that microglial activation or hippocampal neurogenesis accounted for the differences in behavioural outcome. Volumetric analysis revealed that ZnT3 KO mice have larger corpus callosum and parietal cortex volumes, and that corpus callosum volume was decreased by stress in ZnT3 KO, but not wild type, mice.

scholarly journals Amygdala NPY Circuits Promote the Development of Accelerated Obesity under Chronic Stress Conditions

2019 ◽  
Vol 30 (1) ◽  
pp. 111-128.e6 ◽  
Author(s):  
Chi Kin Ip ◽  
Lei Zhang ◽  
Aitak Farzi ◽  
Yue Qi ◽  
Ireni Clarke ◽  
...  
Keyword(s):  
Chronic Stress ◽  
Stress Conditions

Adult Hippocampal Neurogenesis Protects From Chronic Stress Effects in Mice

2020 ◽  
Vol 87 (9) ◽  
pp. S58-S59
Author(s):  
Christoph Anacker ◽  
Victor Luna ◽  
Ryan Shores ◽  
Gregory Stevens ◽  
Rene Hen
Keyword(s):  
Chronic Stress ◽  
Hippocampal Neurogenesis ◽  
Adult Hippocampal Neurogenesis ◽  
Stress Effects

scholarly journals Role of α7- and α4β2-nAChRs in the neuroprotective effect of nicotine in stress-induced impairment of hippocampus-dependent memory

2013 ◽  
Vol 16 (5) ◽  
pp. 1105-1113 ◽  
Author(s):  
Karem H. Alzoubi ◽  
Marisa Srivareerat ◽  
Trinh T. Tran ◽  
Karim A. Alkadhi
Keyword(s):  
Chronic Stress ◽  
Nicotinic Acetylcholine Receptors ◽  
Acetylcholine Receptors ◽  
Short Term Memory ◽  
Neuroprotective Effect ◽  
Stress Conditions ◽  
Nicotine Treatment ◽  
Memory Tests ◽  
Α7 Nachrs

Abstract We have previously shown that nicotine prevents stress-induced memory impairment. In this study, we have investigated the role of α7- and α4β2-nicotinic acetylcholine receptors (nAChRs) in the protective effect of nicotine during chronic stress conditions. Chronic psychosocial stress was induced using a form of rat intruder model. During stress, specific antagonist for either α7-nAChRs [methyllycaconitine (MLA)] or α4β2-nAChRs [dihydro-β-erythroidine (DHβE)] was infused into the hippocampus using a 4-wk osmotic pump at a rate of 82 µg/side.d and 41 µg/side.d, respectively. Three weeks after the start of infusion, all rats were subjected to a series of cognitive tests in the radial arm water maze (RAWM) for six consecutive days or until the animal reached days to criterion (DTC) in the fourth acquisition trial and in all memory tests. DTC is defined as the number of days the animal takes to make no more than one error in three consecutive days. In the short-term memory test, MLA-infused stressed/nicotine-treated rats made similar errors to those of stress and significantly more errors compared to those of stress/nicotine, nicotine or control groups. This finding was supported by the DTC values for the short memory tests. Thus, MLA treatment blocked the neuroprotective effect of nicotine during chronic stress. In contrast, DHβE infusion did not affect the RAWM performance of stress/nicotine animals. These results strongly suggest the involvement of α7-nAChRs, but not α4β2-nAChRs, in the neuroprotective effect of chronic nicotine treatment during chronic stress conditions.

scholarly journals Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression

2007 ◽  
Vol 13 (7) ◽  
pp. 717-728 ◽  
Author(s):  
I Goshen ◽  
T Kreisel ◽  
O Ben-Menachem-Zidon ◽  
T Licht ◽  
J Weidenfeld ◽  
...  
Keyword(s):  
Chronic Stress ◽  
Interleukin 1 ◽  
Hippocampal Neurogenesis
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