scholarly journals Hybrid Antimicrobial Peptide Targeting Staphylococcus aureus and Displaying Anti-infective Activity in a Murine Model

2020 ◽  
Vol 11 ◽  
Author(s):  
Lu Shang ◽  
Jiawei Li ◽  
Chunsheng Song ◽  
Zaytseva Nina ◽  
Qiuke Li ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Antimicrobial Peptide ◽  
Murine Model ◽  
Peptide Targeting ◽  
Infective Activity

Formalin-Fixed Staphylococcus aureus Particles Prevent Allergic Sensitization in a Murine Model of Type I Allergy

2007 ◽  
Vol 144 (3) ◽  
pp. 183-196 ◽  
Author(s):  
Karina Gisch ◽  
Nadine Gehrke ◽  
Matthias Bros ◽  
Christina Priesmeyer ◽  
Jürgen Knop ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Murine Model ◽  
Allergic Sensitization ◽  
Type I ◽  
Type I Allergy ◽  
Formalin Fixed

scholarly journals Demonstration of the preclinical correlate of protection for Staphylococcus aureus clumping factor A in a murine model of infection

Vaccine ◽  
2015 ◽  
Vol 33 (41) ◽  
pp. 5452-5457 ◽  
Author(s):  
Ingrid L. Scully ◽  
Yekaterina Timofeyeva ◽  
David Keeney ◽  
Yury V. Matsuka ◽  
Elena Severina ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Murine Model ◽  
Correlate Of Protection

scholarly journals Novel antimicrobial peptide–modified azithromycin-loaded liposomes against methicillin-resistant Staphylococcus aureus

2016 ◽  
Vol Volume 11 ◽  
pp. 6781-6794 ◽  
Author(s):  
Xiaowei Liu ◽  
Zhan Li ◽  
Xiaodong Wang ◽  
Yujuan Chen ◽  
Fengbo Wu ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Antimicrobial Peptide ◽  
Methicillin Resistant

Nanoparticle-mediated delivery of the antimicrobial peptide plectasin against Staphylococcus aureus in infected epithelial cells

2015 ◽  
Vol 92 ◽  
pp. 65-73 ◽  
Author(s):  
Jorrit Jeroen Water ◽  
Simon Smart ◽  
Henrik Franzyk ◽  
Camilla Foged ◽  
Hanne Mørck Nielsen
Keyword(s):  
Staphylococcus Aureus ◽  
Epithelial Cells ◽  
Antimicrobial Peptide

scholarly journals Role of Antibodies in Protection Elicited by Active Vaccination with Genetically Inactivated Alpha Hemolysin in a Mouse Model of Staphylococcus aureus Skin and Soft Tissue Infections

2014 ◽  
Vol 21 (5) ◽  
pp. 622-627 ◽  
Author(s):  
Christopher P. Mocca ◽  
Rebecca A. Brady ◽  
Drusilla L. Burns
Keyword(s):  
Staphylococcus Aureus ◽  
Soft Tissue ◽  
Murine Model ◽  
Bacterial Colonization ◽  
Passive Immunization ◽  
The United States ◽  
Soft Tissue Infections ◽  
Content Type ◽  
Alpha Hemolysin ◽  
Active Vaccination

ABSTRACTDue to the emergence of highly virulent community-associated methicillin-resistantStaphylococcus aureus(CA-MRSA) infections,S. aureushas become a major threat to public health. A majority of CA-MRSA skin and soft tissue infections in the United States are caused byS. aureusUSA300 strains that are known to produce high levels of alpha hemolysin (Hla). Therefore, vaccines that contain inactivated forms of this toxin are currently being developed. In this study, we sought to determine the immune mechanisms of protection for this antigen using a vaccine composed of a genetically inactivated form of Hla (HlaH35L). Using a murine model of skin and soft tissue infections (SSTI), we found that BALB/c mice were protected by vaccination with HlaH35L; however, Jh mice, which are deficient in mature B lymphocytes and lack IgM and IgG in their serum, were not protected. Passive immunization with anti-HlaH35L antibodies conferred protection against bacterial colonization. Moreover, we found a positive correlation between the total antibody concentration induced by active vaccination and reduced bacterial levels. Animals that developed detectable neutralizing antibody titers after active vaccination were significantly protected from infection. These data demonstrate that antibodies to Hla represent the major mechanism of protection afforded by active vaccination with inactivated Hla in this murine model of SSTI, and in this disease model, antibody levels correlate with protection. These results provide important information for the future development and evaluation ofS. aureusvaccines.

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