scholarly journals Role of Zika Virus prM Protein in Viral Pathogenicity and Use in Vaccine Development

2018 ◽  
Vol 9 ◽  
Author(s):  
Peter Nambala ◽  
Wen-Chi Su
Keyword(s):  
Zika Virus ◽  
Vaccine Development ◽  
Prm Protein

scholarly journals Role of Circulating Immune Complexes in the Pathogenesis of Canine Leishmaniasis: New Players in Vaccine Development

2021 ◽  
Vol 9 (4) ◽  
pp. 712
Author(s):  
Cristina Cacheiro-Llaguno ◽  
Nuria Parody ◽  
Marta R. Escutia ◽  
Jerónimo Carnés
Keyword(s):  
Immune Complexes ◽  
Vaccine Development ◽  
Correct Diagnosis ◽  
Circulating Immune Complexes ◽  
Response To Treatment ◽  
Canine Leishmaniasis ◽  
Leishmania Infection ◽  
Serum Samples ◽  
Humoral Immune

During canine visceral leishmaniasis (CanL), due to Leishmania infantum (L. infantum), uncontrolled infection leads to a strong humoral immune response. As a consequence of the production of high antibody levels and the prolonged presence of parasite antigens, circulating immune complexes (CIC) are formed, which can be deposited in certain organs and tissues, inducing vasculitis, uveitis, dermatitis and especially glomerulonephritis and renal failure. A method to detect CIC and quantify their levels in serum samples from dogs infected with L. infantum has been recently described. It allowed demonstration of a correlation between CIC levels and disease severity. Thus, CIC measurement may be useful for diagnosis, assessment of disease progression and monitoring response to treatment. This is an interesting finding, considering that there remains an urgent need for identification of novel biomarkers to achieve a correct diagnosis and for optimal disease staging of dogs suffering from Leishmania infection. The objective of the present review is to shed light on the role of CIC in CanL, as well as to highlight their potential use not only as diagnostic and prognostic biomarkers but also as a valuable tool in vaccine development and new immunotherapy strategies to prevent or control disease outcome.

scholarly journals Insights into Antibody-Mediated Alphavirus Immunity and Vaccine Development Landscape

2021 ◽  
Vol 9 (5) ◽  
pp. 899
Author(s):  
Anthony Torres-Ruesta ◽  
Rhonda Sin-Ling Chee ◽  
Lisa F.P. Ng
Keyword(s):  
Diagnostic Tests ◽  
Inflammatory Arthritis ◽  
Chikungunya Virus ◽  
Vaccine Development ◽  
Antibody Responses ◽  
Chikv Infection ◽  
Wide Range ◽  
Susceptible Populations ◽  
Humoral Responses

Alphaviruses are mosquito-borne pathogens distributed worldwide in tropical and temperate areas causing a wide range of symptoms ranging from inflammatory arthritis-like manifestations to the induction of encephalitis in humans. Historically, large outbreaks in susceptible populations have been recorded followed by the development of protective long-lasting antibody responses suggesting a potential advantageous role for a vaccine. Although the current understanding of alphavirus antibody-mediated immunity has been mainly gathered in natural and experimental settings of chikungunya virus (CHIKV) infection, little is known about the humoral responses triggered by other emerging alphaviruses. This knowledge is needed to improve serology-based diagnostic tests and the development of highly effective cross-protective vaccines. Here, we review the role of antibody-mediated immunity upon arthritogenic and neurotropic alphavirus infections, and the current research efforts for the development of vaccines as a tool to control future alphavirus outbreaks.

The Role of Predation in Determining Traits of Aedes aegypti (Diptera: Culicidae) and Infection With Zika Virus

2021 ◽  
Author(s):  
Shawna Bellamy ◽  
Barry W Alto
Keyword(s):  
Aedes Aegypti ◽  
Zika Virus ◽  
Life History Traits ◽  
Immature Stages ◽  
Direct Effects ◽  
Infected Blood ◽  
Predator Prey ◽  
Susceptibility To Infection ◽  
Density Reduction

Abstract Non-lethal predator-prey interactions during the immature stages can cause significant changes to mosquito life history traits and their ability to transmit pathogens as adults. Treatment manipulations using mosquitoes Aedes aegypti (L.) and Toxoryhnchites rutilus (Coquillett) were performed during the immature stages to explore the potential impacts of non-lethal interactions on adult susceptibility to infection, disseminated infection and saliva infection of Ae. aegypti following ingestion of Zika virus-infected blood. Treatments inducing density reduction resulted in reduced development time and survivorship to adulthood. However, effects of treatment did not alter infection, dissemination, or saliva infection. These observations indicate that, while non-lethal predation may impact some traits that influence population dynamics and transmission of pathogens, there were no direct effects on mosquito-arbovirus interactions.

scholarly journals The possible role of cross-reactive dengue virus antibodies in Zika virus pathogenesis

2019 ◽  
Vol 15 (4) ◽  
pp. e1007640 ◽  
Author(s):  
Thomas Langerak ◽  
Noreen Mumtaz ◽  
Vera I. Tolk ◽  
Eric C. M. van Gorp ◽  
Byron E. Martina ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Zika Virus

Investigating the Potential Role of North American Animals as Hosts for Zika Virus

2017 ◽  
Vol 17 (3) ◽  
pp. 161-164 ◽  
Author(s):  
Izabela K. Ragan ◽  
Emily L. Blizzard ◽  
Paul Gordy ◽  
Richard A. Bowen
Keyword(s):  
North American ◽  
Zika Virus ◽  
Potential Role

T Cell Immunity and Zika Virus Vaccine Development

2017 ◽  
Vol 38 (8) ◽  
pp. 594-605 ◽  
Author(s):  
Noemia S. Lima ◽  
Morgane Rolland ◽  
Kayvon Modjarrad ◽  
Lydie Trautmann
Keyword(s):  
T Cell ◽  
Virus Vaccine ◽  
Zika Virus ◽  
Vaccine Development ◽  
T Cell Immunity ◽  
Cell Immunity

scholarly journals Pharmacists’ Perception of the Coronavirus Pandemic (COVID-19) in Jordan: A Cross-Sectional Study

2021 ◽  
Vol 18 (21) ◽  
pp. 11541
Author(s):  
Tamara Al-Daghastani ◽  
Odate Tadros ◽  
Shereen Arabiyat ◽  
Deema Jaber ◽  
Husam AlSalamat
Keyword(s):  
Online Survey ◽  
Vaccine Development ◽  
Primary Source ◽  
Cross Sectional Study ◽  
Survey Study ◽  
Sources Of Information ◽  
Cross Sectional ◽  
Protection Measures ◽  
Second Wave

Objectives: To analyze the role of pharmacists during the COVID-19 pandemic, to measure pharmacists’ attitude toward COVID-19 safety measures (wearing masks, wearing gloves, isolation shield, good hygiene, etc.), and explore their perspectives regarding a second wave of the virus. Methods: This cross-sectional online survey study was conducted in Jordan during the COVID-19 outbreak in July 2020 to discuss Jordanian pharmacists’ awareness of safety at their workplace during the COVID-19 outbreak, their sources of information, and their predictions for COVID-19 vaccination. Results: The participants (n = 311) were all pharmacists mostly aged between 23–30 years old (45%) and female (83%). The primary source of information about COVID-19 was social networking (38.9%). Pharmacists were committed to social distancing (86.5%) and wearing masks (76.2%). They expressed levels of agreement to their role in decreasing COVID-19 spread (94.2%) and correcting false information (94.5%); they expressed levels of expectation toward concern about a second COVID-19 wave (83%) that would be more severe than the previous one (43.4%). Pharmacists expected that an influenza vaccine might be helpful in decreasing severity and spread of the COVID-19 pandemic (56.9%). Pharmacists expected COVID-19 vaccine development within 6 months of administering our study survey (84.9%) and that vaccination might be effective in preventing COVID-19 (93%) infection. Conclusion: Pharmacists expressed positive roles on COVID-19 spread through exemplary actions, self-commitment to protection measures, and public health awareness. Social media as a source of health information should be cautiously investigated, and pharmacists should always refer to evidence-based sources. The role of pharmacists is particularly important for the upcoming era of COVID-19 vaccination administration and awareness.

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