scholarly journals SAV4189, a MarR-Family Regulator in Streptomyces avermitilis, Activates Avermectin Biosynthesis

2018 ◽  
Vol 9 ◽  
Author(s):  
Jia Guo ◽  
Xuan Zhang ◽  
Xiaorui Lu ◽  
Wenshuai Liu ◽  
Zhi Chen ◽  
...  
Keyword(s):  
Streptomyces Avermitilis ◽  
Avermectin Biosynthesis

RAPD Analysis on Avermectin High-Producing Strain of Streptomyces Avermilis Irradiated by 12C6+ Ions

2011 ◽  
Vol 339 ◽  
pp. 701-704 ◽  
Author(s):  
Yong Heng Bo ◽  
Shu Yang Wang ◽  
Ji Hong Chen ◽  
Jian Ping Liang
Keyword(s):  
Random Amplified Polymorphic Dna ◽  
Genetic Material ◽  
Similarity Index ◽  
Heavy Ion ◽  
Streptomyces Avermitilis ◽  
Original Strain ◽  
Ion Accelerator ◽  
Modern Physics ◽  
Avermectin Biosynthesis ◽  
Academy Of Sciences

Italic textAbstract. Industrial Streptomyces avermitilis were irradiated by 80 MeV/u 12C6+ ions whith were provided by the Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou Heavy Ion Accelerator. The high titers of mutants were obtained with different doses. The original strains and the high titers of mutants were detected and analyzed by Random Amplified Polymorphic DNA technology (RAPD). The results show that bands could be got from amplify the original strain by 4 primers of 28 primers and the high titers of mutants were amplified by the 4 primers. The amplified products were analysed by Jaccard formula. After 10 Gy, 30 Gy, 40 Gy, 45 Gy, 50 Gy, 70 Gy isodose irradiation, the similarity index were 0.63, 0.75, 0.71, 0.8, 0.61, 0.73. It was confirmed that at the DNA level, not only the high titers strains and the original mutant strain’s DNA were different, but also the high titers of the different mutants’ DNA were different. Therefore, ion implantation method changed the different Streptomyces avermitilis genetic material which promote the importance trace of avermectin biosynthesis changed, and different high titers of Streptomyces avermitilis were obtained.

The PhoP transcription factor negatively regulates avermectin biosynthesis in Streptomyces avermitilis

2015 ◽  
Vol 99 (24) ◽  
pp. 10547-10557 ◽  
Author(s):  
Renjun Yang ◽  
Xingchao Liu ◽  
Ying Wen ◽  
Yuan Song ◽  
Zhi Chen ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Streptomyces Avermitilis ◽  
Avermectin Biosynthesis

scholarly journals A Novel TetR Family Transcriptional Regulator, SAV576, Negatively Controls Avermectin Biosynthesis in Streptomyces avermitilis

PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e71330 ◽  
Author(s):  
Jia Guo ◽  
Xuan Zhang ◽  
Shuai Luo ◽  
Fei He ◽  
Zhi Chen ◽  
...  
Keyword(s):  
Transcriptional Regulator ◽  
Streptomyces Avermitilis ◽  
Avermectin Biosynthesis
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