scholarly journals Excess of Rare Missense Variants in Hearing Loss Genes in Sporadic Meniere Disease

2019 ◽  
Vol 10 ◽  
Author(s):  
Alvaro Gallego-Martinez ◽  
Teresa Requena ◽  
Pablo Roman-Naranjo ◽  
Jose A. Lopez-Escamez
Keyword(s):  
Hearing Loss ◽  
Meniere Disease ◽  
Missense Variants ◽  
Menière Disease

Atypical Meniere Disease: Case Report of a Patient Treated as Sudden Hearing Loss

2012 ◽  
Vol 19 (4) ◽  
pp. 268-271
Author(s):  
Tuba Bayindir ◽  
Erkan Karatas ◽  
Zekeriya Cetinkaya
Keyword(s):  
Hearing Loss ◽  
Case Report ◽  
Sudden Hearing Loss ◽  
Meniere Disease ◽  
Disease Case ◽  
Menière Disease

scholarly journals DNA Methylation Signature in Mononuclear Cells and Proinflammatory Cytokines May Define Molecular Subtypes in Sporadic Meniere Disease

Biomedicines ◽  
2021 ◽  
Vol 9 (11) ◽  
pp. 1530
Author(s):  
Marisa Flook ◽  
Alba Escalera-Balsera ◽  
Alvaro Gallego-Martinez ◽  
Juan Manuel Espinosa-Sanchez ◽  
Ismael Aran ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Hearing Loss ◽  
Mononuclear Cells ◽  
Cpg Island ◽  
Enrichment Analysis ◽  
Meniere Disease ◽  
Disease Mechanisms ◽  
Significant Heritability ◽  
Genome Bisulfite Sequencing ◽  
Menière Disease

Meniere Disease (MD) is a multifactorial disorder of the inner ear characterized by vertigo attacks associated with sensorineural hearing loss and tinnitus with a significant heritability. Although MD has been associated with several genes, no epigenetic studies have been performed on MD. Here we performed whole-genome bisulfite sequencing in 14 MD patients and six healthy controls, with the aim of identifying an MD methylation signature and potential disease mechanisms. We observed a high number of differentially methylated CpGs (DMC) when comparing MD patients to controls (n= 9545), several of them in hearing loss genes, such as PCDH15, ADGRV1 and CDH23. Bioinformatic analyses of DMCs and cis-regulatory regions predicted phenotypes related to abnormal excitatory postsynaptic currents, abnormal NMDA-mediated receptor currents and abnormal glutamate-mediated receptor currents when comparing MD to controls. Moreover, we identified various DMCs in genes previously associated with cochleovestibular phenotypes in mice. We have also found 12 undermethylated regions (UMR) that were exclusive to MD, including two UMR in an inter CpG island in the PHB gene. We suggest that the DNA methylation signature allows distinguishing between MD patients and controls. The enrichment analysis confirms previous findings of a chronic inflammatory process underlying MD.

Persistence of Non-Vertigo Symptoms in Meniere Disease During Remission – A Preliminary Report

2020 ◽  
Vol 74 (4) ◽  
pp. 31-36
Author(s):  
Abiodun Olusesi ◽  
Olubukola Oyeniran
Keyword(s):  
Quality Of Life ◽  
Hearing Loss ◽  
Tertiary Care ◽  
Pure Tone Audiometry ◽  
Life Assessment ◽  
Symptom Scale ◽  
Meniere Disease ◽  
Study Objective ◽  
Menière Disease

Background: Though the absence of vertigo in Meniere disease is often interpreted as remission, patient-centered subjective assessment of quality of life remains the best indicator of such remission. Study Objective: To assess the presence and severity of aural pressure/tinnitus, hearing loss, unsteadiness, nausea and vomiting in MD patients during remission. Setting: Urban tertiary care referral hospital in a developing country. Methodology: Consecutive patients with diagnosis of Definite Meniere were selected from the Balance and Dizziness Clinic of National Hospital Abuja for the study. Quality of life assessment was carried out using 3 validated tools – Modified MD-POSI, Vertigo Symptom Scale and Tinnitus Handicap Inventory (THI). Patients were included only when they have been vertigo free for at least 4 weeks. Pure tone audiometry was carried out in those with subjective hearing loss at recruitment and 4 weeks later. Results: A total of 26 patients completed the study. All had cinnarizine for acute vertigo control and Betahistine for maintenance of vertigo control. There was female preponderance (17:9). The age range was 32–56 years. The duration of MD ranges from 4 months to 12 years. The total and subscale MD-POSI scores for “between attacks” significantly correlated with hearing, unsteadiness and tinnitus/pressure when compared to during attack. 69.2 per cent of participants experienced symptoms of unsteadiness during remission. 13/26 of participants reported persistent, though less annoying tinnitus that poorly correlated with THI score during remission. Conclusion: Our study showed that significant non-vertigo symptoms affect the quality of life during remission. Perhaps there is need to properly define, in future studies, what constitutes remission in patients with MD.

Relationship between Endolymphatic Hydrops and Symptoms of Meniere Disease in Acoustic Hearing

ORL ◽  
2021 ◽  
pp. 1-9
Author(s):  
Yoonkyung Oh ◽  
Jongwoo Lim ◽  
Young Sang Cho ◽  
Namkeun Kim
Keyword(s):  
Hearing Loss ◽  
Middle Ear ◽  
Basilar Membrane ◽  
Endolymphatic Hydrops ◽  
Experimental Studies ◽  
Single Frequency ◽  
Meniere Disease ◽  
Low Frequencies ◽  
Frequency Sound ◽  
Menière Disease

Hypothesis: The endolymphatic hydrops (EH) does not affect hearing loss significantly at low frequencies, whereas the hydrops affects the diplacusis. Background: There have been many arguments whether the EH cause the Meniere disease. Despite a lot of experimental studies to investigate the Meniere disease, there have been little modeling studies, which are helpful to understand the mechanism. Methods: A 3D finite element model of the human cochlea and the middle ear was used for investigation of the relationship between EH and hearing loss at low frequencies and diplacusis (2 specific symptoms of Meniere disease). While the cochlear geometry was simplified as a tapered box shape, the middle ear was based on the real geometry obtained from μCT images. EH is implemented by prestress on the basilar membrane surface in the simulation. Results: The EH did not cause significant hearing loss at low frequencies in both air- and bone-conducted hearing. Rather, this disorder caused a shift in best frequency (BF) position to the base at low frequencies below about 250 Hz. The BF shift can explain the diplacusis because a low-frequency sound can be perceived as a slightly higher frequency so that Meniere patients can perceive 2 different frequency sounds corresponding to a given single-frequency sound. Conclusion: The EH cannot be a sufficient condition for Meniere disease, whereas the hydrops can cause the diplacusis.

scholarly journals DNA Methylation Signature in Mononuclear Cells and Proinflammatory Cytokines May Define Molecular Subtypes in Sporadic Meniere Disease

2021 ◽  
Author(s):  
Marisa Flook ◽  
Alba Escalera-Balsera ◽  
Alvaro Gallego-Martinez ◽  
Juan Manuel Espinosa-Sanchez ◽  
Ismael Aran ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Hearing Loss ◽  
Mononuclear Cells ◽  
Cpg Island ◽  
Enrichment Analysis ◽  
Meniere Disease ◽  
Disease Mechanisms ◽  
Significant Heritability ◽  
Genome Bisulfite Sequencing ◽  
Menière Disease

Meniere Disease (MD) is a multifactorial disorder of the inner ear characterized by vertigo attacks associated with sensorineural hearing loss and tinnitus with a significant heritability. Although MD has been associated with several genes, no epigenetic studies have been performed in MD. Here we performed whole genome bisulfite sequencing in 14 MD patients and 6 healthy controls, with the aim of identifying a MD methylation signature and potential disease mechanisms. We observed a high number of differentially methylated CpGs (DMC) when comparing MD patients to controls (N= 9,545), several of them in hearing loss genes such as PCDH15, ADGRV1 and CDH23. Bioinformatic analyses of DMCs and cis-regulatory regions predicted phenotypes related to abnormal excitatory postsynaptic currents, abnormal NMDA-mediated receptor currents and abnormal glutamate-mediated receptor currents when comparing MD to controls. Moreover, we identified various DMCs in genes previously associated with cochleovestibular phenotypes in mice. We have also found 12 undermethylated regions (UMR) that were exclusive to MD, including 2 UMR in an inter CpG island in the PHB gene. We suggest that the DNA methylation signature allows to distinguish between MD patients and controls. The enrichment analysis confirms previous findings of a chronic inflammatory process underlying MD.

A Predictive Model of Bilateral Sensorineural Hearing Loss in Meniere Disease Using Clinical Data

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
M. D. Carmen Moleon ◽  
Lidia Torres-Garcia ◽  
Angel Batuecas-Caletrio ◽  
Natalia Castillo-Ledesma ◽  
Rocio Gonzalez-Aguado ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Predictive Model ◽  
Clinical Data ◽  
Sensorineural Hearing ◽  
Meniere Disease ◽  
Bilateral Sensorineural Hearing Loss ◽  
Menière Disease
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