Relationship between Endolymphatic Hydrops and Symptoms of Meniere Disease in Acoustic Hearing

ORL ◽  
2021 ◽  
pp. 1-9
Author(s):  
Yoonkyung Oh ◽  
Jongwoo Lim ◽  
Young Sang Cho ◽  
Namkeun Kim
Keyword(s):  
Hearing Loss ◽  
Middle Ear ◽  
Basilar Membrane ◽  
Endolymphatic Hydrops ◽  
Experimental Studies ◽  
Single Frequency ◽  
Meniere Disease ◽  
Low Frequencies ◽  
Frequency Sound ◽  
Menière Disease

Hypothesis: The endolymphatic hydrops (EH) does not affect hearing loss significantly at low frequencies, whereas the hydrops affects the diplacusis. Background: There have been many arguments whether the EH cause the Meniere disease. Despite a lot of experimental studies to investigate the Meniere disease, there have been little modeling studies, which are helpful to understand the mechanism. Methods: A 3D finite element model of the human cochlea and the middle ear was used for investigation of the relationship between EH and hearing loss at low frequencies and diplacusis (2 specific symptoms of Meniere disease). While the cochlear geometry was simplified as a tapered box shape, the middle ear was based on the real geometry obtained from μCT images. EH is implemented by prestress on the basilar membrane surface in the simulation. Results: The EH did not cause significant hearing loss at low frequencies in both air- and bone-conducted hearing. Rather, this disorder caused a shift in best frequency (BF) position to the base at low frequencies below about 250 Hz. The BF shift can explain the diplacusis because a low-frequency sound can be perceived as a slightly higher frequency so that Meniere patients can perceive 2 different frequency sounds corresponding to a given single-frequency sound. Conclusion: The EH cannot be a sufficient condition for Meniere disease, whereas the hydrops can cause the diplacusis.

scholarly journals Excess of Rare Missense Variants in Hearing Loss Genes in Sporadic Meniere Disease

2019 ◽  
Vol 10 ◽  
Author(s):  
Alvaro Gallego-Martinez ◽  
Teresa Requena ◽  
Pablo Roman-Naranjo ◽  
Jose A. Lopez-Escamez
Keyword(s):  
Hearing Loss ◽  
Meniere Disease ◽  
Missense Variants ◽  
Menière Disease

scholarly journals Bridging the gap between chronic cerebrospinal venous insufficiency and Ménière disease

2016 ◽  
Vol 5 (2) ◽  
Author(s):  
Dario C. Alpini ◽  
Pietro M. Bavera ◽  
Federica Di Berardino ◽  
Stefania Barozzi ◽  
Piero Cecconi ◽  
...  
Keyword(s):  
Inner Ear ◽  
Major Part ◽  
Venous Insufficiency ◽  
Endolymphatic Hydrops ◽  
Meniere Disease ◽  
Number Of Patients ◽  
Hydraulic Mechanism ◽  
Collateral Pathways ◽  
Menière Disease ◽  
Global Brain

Ménière disease (MD) is a chronic illness of the inner ear that affects a substantial number of patients every year worldwide. Because of a dearth of well-controlled studies, the medical and surgical management of MD remains quite empirical. The main reason is that it is very difficult to investigate patients affected with Certain MD due to the post-mortem criterion necessary for this diagnostic grade. Although Endolymphatic Hydrops (EH) is the worldwide accepted mechanism of MD, the causes that induce it are still not clear. In fact MD has been correlated mostly to a wide and different disturbances ranging from trauma to sleep disorders. It is nowadays sufficiently demonstrated that Chronic Cerebro Spinal Venous Insufficiency (CCSVI) is very frequent in MD. Even if CCSVI may potentially induce EH through a pure hydraulic mechanism CCSVI, per se does not explain how the various disorders correlated with MD may interact with CCSVI and provoke EH. The aim of this review is an attempt to approach MD into the context of the more recent findings about the global brain waste clearance system, to which inner ear is anatomically and functionally connected, in order to build a reasonable model of MD pathogenesis. The major part of the diseases correlated to MD may act on the inner ear disturbing the Glymphatic (GS) and/or Brain Lymphatic System (BLS) activity. The venous system interplays with GS and BLS. In this model CCSVI is considered more than a direct cause of MD rather the anatomical predisposition to develop the disease. In this model EH, and then MD, is the consequence of a failure of the compensation of the congenital venous abnormalities, anatomical compensation as collateral pathways and/or functional compensation as GS and BLS. In this model the major part of the disturbances correlated to MD and the various treatment proposed find their appropriate placement.

Influence of ossicular chain malformation on the performance of round-window stimulation: A finite element approach

2019 ◽  
Vol 233 (5) ◽  
pp. 584-594 ◽  
Author(s):  
Houguang Liu ◽  
Hu Zhang ◽  
Jianhua Yang ◽  
Xinsheng Huang ◽  
Wen Liu ◽  
...  
Keyword(s):  
Finite Element ◽  
Middle Ear ◽  
Basilar Membrane ◽  
Round Window ◽  
Low Frequency ◽  
Element Model ◽  
Ossicular Chain ◽  
Asymmetric Structure ◽  
Low Frequencies ◽  
Stapes Fixation

As a novel application of implantable middle ear hearing device, round-window stimulation is widely used to treat hearing loss with middle ear disease, such as ossicular chain malformation. To evaluate the influence of ossicular chain malformations on the efficiency of the round-window stimulation, a human ear finite element model, which incorporates cochlear asymmetric structure, was constructed. Five groups of comparison with experimental data confirmed the model’s validity. Based on this model, we investigated the influence of three categories of ossicular chain malformations, that is, incudostapedial disconnection, incus and malleus fixation, and fixation of the stapes. These malformations’ effects were evaluated by comparing the equivalent sound pressures derived from the basilar membrane displacement. Results show that the studied ossicular chain malformations mainly affected the round-window simulation’s performance at low frequencies. In contrast to the fixation of the ossicles, which mainly deteriorates round-window simulation’s low-frequency performance, incudostapedial disconnection increases this performance, especially in the absence of incus process and stapes superstructure. Among the studied ossicular chain malformations, the stapes fixation has a much more severe impact on the round-window stimulation’s efficiency. Thus, the influence of the patients’ ossicular chain malformations should be considered in the design of the round-window stimulation’s actuator. The low-frequency output of the round-window simulation’s actuator should be enhanced, especially for treating the patients with stapes fixation.

Atypical Meniere Disease: Case Report of a Patient Treated as Sudden Hearing Loss

2012 ◽  
Vol 19 (4) ◽  
pp. 268-271
Author(s):  
Tuba Bayindir ◽  
Erkan Karatas ◽  
Zekeriya Cetinkaya
Keyword(s):  
Hearing Loss ◽  
Case Report ◽  
Sudden Hearing Loss ◽  
Meniere Disease ◽  
Disease Case ◽  
Menière Disease

scholarly journals Comparative studies of the therapeutic effects of inner ear anesthesia and middle ear infusion of a steroid solution for Meniere disease.

1987 ◽  
Vol 80 (1) ◽  
pp. 57-65 ◽  
Author(s):  
Eiji Sakata ◽  
Naoko Itoh ◽  
Akinori Itoh ◽  
Hiroshi Nakazawa ◽  
Koki Nakaigawa ◽  
...  
Keyword(s):  
Inner Ear ◽  
Middle Ear ◽  
Comparative Studies ◽  
Therapeutic Effects ◽  
Meniere Disease ◽  
Menière Disease

R441 – 3D Finite Element Model for Perilymphatic Fistula

2008 ◽  
Vol 139 (2_suppl) ◽  
pp. P192-P192
Author(s):  
Ken Hayashi ◽  
Koike Takuji ◽  
Sho Kanzaki ◽  
Kaoru Ogawa
Keyword(s):  
Finite Element ◽  
Hearing Loss ◽  
Clinical Data ◽  
Basilar Membrane ◽  
Maximum Amplitude ◽  
Annular Ligament ◽  
Fe Model ◽  
Low Frequencies ◽  
Air Bubble ◽  
Scala Vestibuli

Problem To investigate the relationship between the intrusion of the air bubble into the scala vestibli and hearing loss at low frequencies. Methods The effect of intrusion of an air bubble into the scala vestibuli on auditory activity was analyzed based on clinical data and using a three-dimensional finite element (FE) model of the human cochlea. The FE model consists of the stapes, the stapedial annular ligament, the oval window, vestibule, lymph, basilar membrane, osseous spiral lamina, and the cochlear aqueduct. An air bubble in the scala vestibuli was modeled as a small fistula opened on the bony wall of the cochlea. The induced vibration of the lymph and the basilar membrane was calculated by changing the position of the air bubble using CFD-ACE software. Results A traversing wave was generated on the basilar membrane of the intact cochlear model by vibrating the stapes. Even if the air bubble existed in the scala vestibuli, the traversing wave was also generated. When the air bubble existed at the second turn of the cochlea, an envelope of the traversing wave had a notch at the portion where the air bubble existed. The ratio of the maximum amplitude of the basilar membrane in the cochlea with the air bubble to that in the intact cochlea decreased with decreasing frequency. The maximum amplitude of the traversing wave in the cochlea with the air bubble was smaller than that in the intact cochlea by 20 dB at 500 Hz. This result is consistent with clinical data. Conclusion Our results suggest that the intrusion of an air bubble into the scala vestibuli causes hearing loss at low frequencies. Significance The removal of air bubbles into the scala vestibli is needed for hearing improvement.

scholarly journals DNA Methylation Signature in Mononuclear Cells and Proinflammatory Cytokines May Define Molecular Subtypes in Sporadic Meniere Disease

Biomedicines ◽  
2021 ◽  
Vol 9 (11) ◽  
pp. 1530
Author(s):  
Marisa Flook ◽  
Alba Escalera-Balsera ◽  
Alvaro Gallego-Martinez ◽  
Juan Manuel Espinosa-Sanchez ◽  
Ismael Aran ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Hearing Loss ◽  
Mononuclear Cells ◽  
Cpg Island ◽  
Enrichment Analysis ◽  
Meniere Disease ◽  
Disease Mechanisms ◽  
Significant Heritability ◽  
Genome Bisulfite Sequencing ◽  
Menière Disease

Meniere Disease (MD) is a multifactorial disorder of the inner ear characterized by vertigo attacks associated with sensorineural hearing loss and tinnitus with a significant heritability. Although MD has been associated with several genes, no epigenetic studies have been performed on MD. Here we performed whole-genome bisulfite sequencing in 14 MD patients and six healthy controls, with the aim of identifying an MD methylation signature and potential disease mechanisms. We observed a high number of differentially methylated CpGs (DMC) when comparing MD patients to controls (n= 9545), several of them in hearing loss genes, such as PCDH15, ADGRV1 and CDH23. Bioinformatic analyses of DMCs and cis-regulatory regions predicted phenotypes related to abnormal excitatory postsynaptic currents, abnormal NMDA-mediated receptor currents and abnormal glutamate-mediated receptor currents when comparing MD to controls. Moreover, we identified various DMCs in genes previously associated with cochleovestibular phenotypes in mice. We have also found 12 undermethylated regions (UMR) that were exclusive to MD, including two UMR in an inter CpG island in the PHB gene. We suggest that the DNA methylation signature allows distinguishing between MD patients and controls. The enrichment analysis confirms previous findings of a chronic inflammatory process underlying MD.

scholarly journals Endolymphatic hydrops imaging: Differential diagnosis in patients with Meniere disease symptoms

2017 ◽  
Vol 98 (10) ◽  
pp. 699-706 ◽  
Author(s):  
A. Attyé ◽  
M. Eliezer ◽  
A. Galloux ◽  
J. Pietras ◽  
I. Tropres ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Endolymphatic Hydrops ◽  
Meniere Disease ◽  
Disease Symptoms ◽  
Menière Disease
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