scholarly journals Genetic Separation of Listeria monocytogenes Causing Central Nervous System Infections in Animals

Author(s):  
Lisandra Aguilar-Bultet ◽  
Pamela Nicholson ◽  
Lorenz Rychener ◽  
Margaux Dreyer ◽  
Bulent Gözel ◽  
...  
2002 ◽  
Vol 68 (2) ◽  
pp. 616-622 ◽  
Author(s):  
C. Jacquet ◽  
E. Gouin ◽  
D. Jeannel ◽  
P. Cossart ◽  
J. Rocourt

ABSTRACT Expression of proteins involved in the adhesion of Listeria monocytogenes to mammalian cells or in the intracellular life cycle of this bacterium, including listeriolysin O (LLO), ActA, Ami, and InlB, was used to compare two populations of L. monocytogenes strains. One of the populations comprised 300 clinical strains, and the other comprised 150 food strains. All strains expressed LLO, InlB, and ActA. No polymorphism was observed for LLO and InlB. Ami was detected in 283 of 300 human strains and in 149 of 150 food strains. The strains in which Ami was not detected were serovar 4b strains. Based on the molecular weights of the proteins detected, the strains were divided into two groups with Ami (groups Ami1 [75% of the strains] and Ami2 [21%]) and into four groups with ActA (groups ActA1 [52% of the strains], ActA2 [18%], ActA3 [30%], and ActA4 [one strain isolated from food]). Logistic regression showed that food strains were more likely to belong to group ActA3 than human strains (odds ratio [OR] = 2.90; P = 1 � 10−4). Of the strains isolated from patients with non-pregnancy-related cases of listeriosis, bacteremia was predominantly associated with group Ami1 strains (OR = 1.89; P = 1 � 10−2) and central nervous system infections were associated with group ActA2 strains (OR = 3.04; P = 1 � 10−3) and group ActA3 strains (OR = 3.91; P = 1 � 10−3).


2014 ◽  
Vol 67 (11-12) ◽  
pp. 407-409
Author(s):  
Snezana Delic ◽  
Snezana Brkic ◽  
Aleksandar Delic ◽  
Ivana Cirkovic

Introduction. Listeria monocytogenes is one of the most common causes of bacterial central nervous system infections in adults. It often affects immunicompromised and elderly patients. Even with appropriate antimicrobial treatment, mortality due to Listeria monocytogenes meningoencephalitis is among the highest of all causes of bacterial central nervous system infections. Case report. We presented a previously healthy, 79-year-old farmer with typical clinical features of meningoencephalitis. The initial treatment with vancomycin and meropenem did not produce any clinical effect. On day six, Listeria monocytogenes was isolated from the cerebrospinal fluid and blood culture and identified by using conventional and automated microbiology methods. Antimicrobial susceptibility testing was performed by E test method. After bacterial isolation and identification, the administration of ampicillin and gentamicin was followed by the complete recovery of our patient. Conclusion. This case is presented to emphasize the negative outcome of empirical treatment when Listeria monocytogenes is not taken into consideration. Furthermore, the administration of ampicillin and gentamicin combination for treatment should be considered as the best therapeutic option in Listeria monocytogenes meningoencephalitis.


1980 ◽  
Vol 96 (3) ◽  
pp. 559-563 ◽  
Author(s):  
Jonathan I. Singer ◽  
Philip R. Maur ◽  
John P. Riley ◽  
Pamela Burger Smith

2001 ◽  
Vol 43 (12) ◽  
pp. 1031-1039 ◽  
Author(s):  
J. Teixeira ◽  
R. Zimmerman ◽  
J. Haselgrove ◽  
L. Bilaniuk ◽  
J. Hunter

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