scholarly journals The early interaction of Leishmania with macrophages and dendritic cells and its influence on the host immune response

2012 ◽  
Vol 2 ◽  
Author(s):  
Dong Liu ◽  
Jude E. Uzonna
Keyword(s):  
Immune Response ◽  
Dendritic Cells ◽  
Host Immune Response ◽  
Early Interaction

scholarly journals Failure To Recruit Anti-Inflammatory CD103+Dendritic Cells and a Diminished CD4+Foxp3+Regulatory T Cell Pool in Mice That Display Excessive Lung Inflammation and Increased Susceptibility to Mycobacterium tuberculosis

2012 ◽  
Vol 80 (3) ◽  
pp. 1128-1139 ◽  
Author(s):  
Chaniya Leepiyasakulchai ◽  
Lech Ignatowicz ◽  
Andrzej Pawlowski ◽  
Gunilla Källenius ◽  
Markus Sköld
Keyword(s):  
Immune Response ◽  
Dendritic Cells ◽  
Mycobacterium Tuberculosis ◽  
T Cell ◽  
Bacterial Growth ◽  
Lung Inflammation ◽  
Chronic Infection ◽  
Host Immune Response ◽  
Content Type ◽  
Tnf Α

Susceptibility toMycobacterium tuberculosisis characterized by excessive lung inflammation, tissue damage, and failure to control bacterial growth. To increase our understanding of mechanisms that may regulate the host immune response in the lungs, we characterized dendritic cells expressing CD103 (αEintegrin) (αE-DCs) and CD4+Foxp3+regulatory T (Treg) cells duringM. tuberculosisinfection. In resistant C57BL/6 and BALB/c mice, the number of lung αE-DCs increased dramatically duringM. tuberculosisinfection. In contrast, highly susceptible DBA/2 mice failed to recruit αE-DCs even during chronic infection. Even though tumor necrosis factor alpha (TNF-α) is produced by multiple DCs and macrophage subsets and is required for control of bacterial growth, αE-DCs remained TNF-α negative. Instead, αE-DCs contained a high number of transforming growth factor beta-producing cells in infected mice. Further, we show that Tregcells in C57BL/6 and DBA/2 mice induce gamma interferon during pulmonary tuberculosis. In contrast to resistant mice, the Tregcell population was diminished in the lungs, but not in the draining pulmonary lymph nodes (PLN), of highly susceptible mice during chronic infection. Tregcells have been reported to inhibitM. tuberculosis-specific T cell immunity, leading to increased bacterial growth. Still, despite the reduced number of lung Tregcells in DBA/2 mice, the bacterial load in the lungs was increased compared to resistant animals. Our results show that αE-DCs and Tregcells that may regulate the host immune response are increased inM. tuberculosis-infected lungs of resistant mice but diminished in infected lungs of susceptible mice.

scholarly journals Dendritic Cells Are Central Coordinators of the Host Immune Response to Staphylococcus aureus Bloodstream Infection

2012 ◽  
Vol 181 (4) ◽  
pp. 1327-1337 ◽  
Author(s):  
Daniela Schindler ◽  
Maximiliano G. Gutierrez ◽  
Andreas Beineke ◽  
Yvonne Rauter ◽  
Manfred Rohde ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Immune Response ◽  
Dendritic Cells ◽  
Bloodstream Infection ◽  
Host Immune Response ◽  
Staphylococcus Aureus Bloodstream Infection

scholarly journals Glycans from Fasciola hepatica Modulate the Host Immune Response and TLR-Induced Maturation of Dendritic Cells

2015 ◽  
Vol 9 (12) ◽  
pp. e0004234 ◽  
Author(s):  
Ernesto Rodríguez ◽  
Verónica Noya ◽  
Laura Cervi ◽  
María Laura Chiribao ◽  
Natalie Brossard ◽  
...  
Keyword(s):  
Immune Response ◽  
Dendritic Cells ◽  
Fasciola Hepatica ◽  
Host Immune Response

scholarly journals DNA vaccination strategy targets epidermal dendritic cells, initiating their migration and induction of a host immune response

2014 ◽  
Vol 1 ◽  
pp. 14054 ◽  
Author(s):  
Trevor RF Smith ◽  
Katherine Schultheis ◽  
William B Kiosses ◽  
Dinah H Amante ◽  
Janess M Mendoza ◽  
...  
Keyword(s):  
Immune Response ◽  
Dendritic Cells ◽  
Vaccination Strategy ◽  
Host Immune Response ◽  
Dna Vaccination ◽  
Epidermal Dendritic Cells
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