scholarly journals Human Melanocyte-Derived Spheroids: A Precise Test System for Drug Screening and a Multicellular Unit for Tissue Engineering

2020 ◽  
Vol 8 ◽  
Author(s):  
Irina M. Zurina ◽  
Anastasiya A. Gorkun ◽  
Ekaterina V. Dzhussoeva ◽  
Tamara D. Kolokoltsova ◽  
Dmitriy D. Markov ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Drug Screening ◽  
Test System ◽  
Human Melanocyte

scholarly journals Tissue Engineering of a Human 3D in vitro Tumor Test System

10.3791/50460 ◽  
2013 ◽  
Author(s):  
Corinna Moll ◽  
Jenny Reboredo ◽  
Thomas Schwarz ◽  
Antje Appelt ◽  
Sebastian Schürlein ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Test System ◽  
3D Em

Modular and Customized Fabrication of 3D Functional Microgels for Bottom‐Up Tissue Engineering and Drug Screening

2020 ◽  
Vol 5 (5) ◽  
pp. 1900847 ◽  
Author(s):  
Wenguang Yang ◽  
Shuxiang Cai ◽  
Yibao Chen ◽  
Wenfeng Liang ◽  
Youbin Lai ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Drug Screening ◽  
Bottom Up

scholarly journals Human iPSC-derived cardiomyocytes and tissue engineering strategies for disease modeling and drug screening

2017 ◽  
Vol 35 (1) ◽  
pp. 77-94 ◽  
Author(s):  
Alec S.T. Smith ◽  
Jesse Macadangdang ◽  
Winnie Leung ◽  
Michael A. Laflamme ◽  
Deok-Ho Kim
Keyword(s):  
Tissue Engineering ◽  
Drug Screening ◽  
Disease Modeling ◽  
Human Ipsc

scholarly journals Human iPSCs and Genome Editing Technologies for Precision Cardiovascular Tissue Engineering

2021 ◽  
Vol 9 ◽  
Author(s):  
Eric K. N. Gähwiler ◽  
Sarah E. Motta ◽  
Marcy Martin ◽  
Bramasta Nugraha ◽  
Simon P. Hoerstrup ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Cell Lines ◽  
Drug Screening ◽  
Genome Engineering ◽  
Molecular Mechanisms ◽  
Disease Modeling ◽  
Cell Types ◽  
Cardiovascular Tissue ◽  
Human Ipscs ◽  
Cardiovascular Tissue Engineering

Induced pluripotent stem cells (iPSCs) originate from the reprogramming of adult somatic cells using four Yamanaka transcription factors. Since their discovery, the stem cell (SC) field achieved significant milestones and opened several gateways in the area of disease modeling, drug discovery, and regenerative medicine. In parallel, the emergence of clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein 9 (CRISPR-Cas9) revolutionized the field of genome engineering, allowing the generation of genetically modified cell lines and achieving a precise genome recombination or random insertions/deletions, usefully translated for wider applications. Cardiovascular diseases represent a constantly increasing societal concern, with limited understanding of the underlying cellular and molecular mechanisms. The ability of iPSCs to differentiate into multiple cell types combined with CRISPR-Cas9 technology could enable the systematic investigation of pathophysiological mechanisms or drug screening for potential therapeutics. Furthermore, these technologies can provide a cellular platform for cardiovascular tissue engineering (TE) approaches by modulating the expression or inhibition of targeted proteins, thereby creating the possibility to engineer new cell lines and/or fine-tune biomimetic scaffolds. This review will focus on the application of iPSCs, CRISPR-Cas9, and a combination thereof to the field of cardiovascular TE. In particular, the clinical translatability of such technologies will be discussed ranging from disease modeling to drug screening and TE applications.

Hair follicular cell cultures in tissue engineering and drug screening

2009 ◽  
Vol 108 ◽  
pp. S29
Author(s):  
Jung-Keug Park ◽  
Bo-Young Yoo ◽  
Hee-Hoon Yoon ◽  
Youn-Ho Shin ◽  
Kye-Yong Song
Keyword(s):  
Tissue Engineering ◽  
Cell Cultures ◽  
Drug Screening ◽  
Follicular Cell
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