scholarly journals Tissue engineering the cardiac microenvironment: Multicellular microphysiological systems for drug screening

2016 ◽  
Vol 96 ◽  
pp. 225-233 ◽  
Author(s):  
Yosuke K. Kurokawa ◽  
Steven C. George
Keyword(s):  
Tissue Engineering ◽  
Drug Screening ◽  
Microphysiological Systems

scholarly journals Fiber-based microphysiological systems: a powerful tool for high throughput drug screening

2019 ◽  
Vol 3 ◽  
pp. 3-3 ◽  
Author(s):  
Tavia Walsh ◽  
Lucas Karperien ◽  
Seyed Mohammad Hossein Dabiri ◽  
Mohsen Akbari
Keyword(s):  
High Throughput ◽  
Drug Screening ◽  
High Throughput Drug Screening ◽  
Microphysiological Systems

Modular and Customized Fabrication of 3D Functional Microgels for Bottom‐Up Tissue Engineering and Drug Screening

2020 ◽  
Vol 5 (5) ◽  
pp. 1900847 ◽  
Author(s):  
Wenguang Yang ◽  
Shuxiang Cai ◽  
Yibao Chen ◽  
Wenfeng Liang ◽  
Youbin Lai ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Drug Screening ◽  
Bottom Up

scholarly journals Advancing cardiovascular tissue engineering

F1000Research ◽  
2016 ◽  
Vol 5 ◽  
pp. 1045 ◽  
Author(s):  
George A. Truskey
Keyword(s):  
Tissue Engineering ◽  
Cardiac Tissue ◽  
Great Promise ◽  
Mechanical Stimuli ◽  
Cardiovascular Tissue ◽  
Microphysiological Systems ◽  
Cardiovascular Tissue Engineering ◽  
Induced Pluripotent ◽  
Improved Methods

Cardiovascular tissue engineering offers the promise of biologically based repair of injured and damaged blood vessels, valves, and cardiac tissue. Major advances in cardiovascular tissue engineering over the past few years involve improved methods to promote the establishment and differentiation of induced pluripotent stem cells (iPSCs), scaffolds from decellularized tissue that may produce more highly differentiated tissues and advance clinical translation, improved methods to promote vascularization, and novel in vitro microphysiological systems to model normal and diseased tissue function. iPSC technology holds great promise, but robust methods are needed to further promote differentiation. Differentiation can be further enhanced with chemical, electrical, or mechanical stimuli.

scholarly journals Tissue Engineering: Reconfigurable Microphysiological Systems for Modeling Innervation and Multitissue Interactions (Adv. Biosys. 9/2020)

2020 ◽  
Vol 4 (9) ◽  
pp. 2070091
Author(s):  
Jonathan R. Soucy ◽  
Adam J. Bindas ◽  
Ryan Brady ◽  
Tess Torregrosa ◽  
Cailey M. Denoncourt ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Microphysiological Systems

scholarly journals Tissue chips – innovative tools for drug development and disease modeling

Lab on a Chip ◽  
2017 ◽  
Vol 17 (18) ◽  
pp. 3026-3036 ◽  
Author(s):  
L. A. Low ◽  
D. A. Tagle
Keyword(s):  
Tissue Engineering ◽  
Drug Development ◽  
Disease Modeling ◽  
High Rate ◽  
Human Organs ◽  
Recent Advances ◽  
Microphysiological Systems ◽  
Rate Of Failure

The high rate of failure during drug development is well-known, however recent advances in tissue engineering and microfabrication have contributed to the development of microphysiological systems (MPS), or ‘organs-on-chips’ that recapitulate the function of human organs.

scholarly journals Human iPSC-derived cardiomyocytes and tissue engineering strategies for disease modeling and drug screening

2017 ◽  
Vol 35 (1) ◽  
pp. 77-94 ◽  
Author(s):  
Alec S.T. Smith ◽  
Jesse Macadangdang ◽  
Winnie Leung ◽  
Michael A. Laflamme ◽  
Deok-Ho Kim
Keyword(s):  
Tissue Engineering ◽  
Drug Screening ◽  
Disease Modeling ◽  
Human Ipsc

scholarly journals Enhancing Kidney Vasculature in Tissue Engineering—Current Trends and Approaches: A Review

Biomimetics ◽  
2021 ◽  
Vol 6 (2) ◽  
pp. 40
Author(s):  
Charlotta G. Lebedenko ◽  
Ipsita A. Banerjee
Keyword(s):  
Tissue Engineering ◽  
Large Scale ◽  
Kidney Diseases ◽  
Kidney Tissue ◽  
Small Scale ◽  
Current Trends ◽  
Large Size ◽  
Microphysiological Systems ◽  
Primary Obstacle ◽  
Kidney Stem Cells

Chronic kidney diseases are a leading cause of fatalities around the world. As the most sought-after organ for transplantation, the kidney is of immense importance in the field of tissue engineering. The primary obstacle to the development of clinically relevant tissue engineered kidneys is precise vascularization due to the organ’s large size and complexity. Current attempts at whole-kidney tissue engineering include the repopulation of decellularized kidney extracellular matrices or vascular corrosion casts, but these approaches do not eliminate the need for a donor organ. Stem cell-based approaches, such as kidney organoids vascularized in microphysiological systems, aim to construct a kidney without the need for organ donation. These organ-on-a-chip models show complex, functioning kidney structures, albeit at a small scale. Novel methodologies for developing engineered scaffolds will allow for improved differentiation of kidney stem cells and organoids into larger kidney grafts with clinical applications. While currently, kidney tissue engineering remains mostly limited to individual renal structures or small organoids, further developments in vascularization techniques, with technologies such as organoids in microfluidic systems, could potentially open doors for a large-scale growth of whole engineered kidneys for transplantation.

scholarly journals Human iPSCs and Genome Editing Technologies for Precision Cardiovascular Tissue Engineering

2021 ◽  
Vol 9 ◽  
Author(s):  
Eric K. N. Gähwiler ◽  
Sarah E. Motta ◽  
Marcy Martin ◽  
Bramasta Nugraha ◽  
Simon P. Hoerstrup ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Cell Lines ◽  
Drug Screening ◽  
Genome Engineering ◽  
Molecular Mechanisms ◽  
Disease Modeling ◽  
Cell Types ◽  
Cardiovascular Tissue ◽  
Human Ipscs ◽  
Cardiovascular Tissue Engineering

Induced pluripotent stem cells (iPSCs) originate from the reprogramming of adult somatic cells using four Yamanaka transcription factors. Since their discovery, the stem cell (SC) field achieved significant milestones and opened several gateways in the area of disease modeling, drug discovery, and regenerative medicine. In parallel, the emergence of clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein 9 (CRISPR-Cas9) revolutionized the field of genome engineering, allowing the generation of genetically modified cell lines and achieving a precise genome recombination or random insertions/deletions, usefully translated for wider applications. Cardiovascular diseases represent a constantly increasing societal concern, with limited understanding of the underlying cellular and molecular mechanisms. The ability of iPSCs to differentiate into multiple cell types combined with CRISPR-Cas9 technology could enable the systematic investigation of pathophysiological mechanisms or drug screening for potential therapeutics. Furthermore, these technologies can provide a cellular platform for cardiovascular tissue engineering (TE) approaches by modulating the expression or inhibition of targeted proteins, thereby creating the possibility to engineer new cell lines and/or fine-tune biomimetic scaffolds. This review will focus on the application of iPSCs, CRISPR-Cas9, and a combination thereof to the field of cardiovascular TE. In particular, the clinical translatability of such technologies will be discussed ranging from disease modeling to drug screening and TE applications.

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