scholarly journals Association of Anthropometric Measurements With Oxidant-Antioxidant Status Among Young Saudi Females

2018 ◽  
pp. 787-793
Author(s):  
R. LATIF ◽  
N. RAFIQUE
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Body Fat ◽  
Positive Association ◽  
Normal Weight ◽  
The Body ◽  
Anthropometric Measurements ◽  
Oxidative Stress Biomarkers ◽  
Obese Adolescent ◽  
Stress Biomarkers

Present study aimed to explore the levels and correlation of oxidative stress biomarkers with anthropometry in a population of young Saudi females. One hundred six normotensives, non-diabetic Saudi females, with minimally active lifestyle, based on their body mass index (BMI) were divided as; normal-weight (NW; n=52), overweight (OW; n=24) and obese (OB; n=30). Anthropometric measurements [BMI, Waist Circumference (WC), Waist-Hip Ratio (WHR), Body Density (BD), Body Adiposity Index (BAI), % Body fat] and oxidative stress biomarkers; Thiobarbituric acid reactive substances (TBARS), 8-hydroxy-2-deoxyguanosine (8-OH-2dG: indicative of DNA/RNA damage), Superoxide dismutase, Serum total antioxidant capacity) were recorded. There was statistically significant higher 8-OH-2dG (pg/ml) in OB compared to NW (800.63±6.19 vs. 780.22±3.34; p=0.007), as determined by one-way ANOVA and Tukey post hoc test. 8-OH-2dG was significantly and positively associated with BMI (r=0.286, p=0.004), WC (r=0.280, p=0.005), BAI (r=0.26, p=0.008), and % body fat (r=0.27, p=0.006). There may be significantly increased DNA damage in normoglycemic, normotensive obese adolescent females. This can be linked to the amount of adipose tissue in the body as depicted by strong positive association between DNA damage and BMI, WC, BAI, and % body fat.

Early ROS-mediated DNA damage and oxidative stress biomarkers in Monoclonal B Lymphocytosis

2012 ◽  
Vol 317 (2) ◽  
pp. 144-149 ◽  
Author(s):  
Rosa Collado ◽  
Isabel Oliver ◽  
Carmen Tormos ◽  
Mercedes Egea ◽  
Amparo Miguel ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Oxidative Stress Biomarkers ◽  
Stress Biomarkers ◽  
And Oxidative Stress

scholarly journals Antioxidants and Oxidative Stress in Children: Influence of Puberty and Metabolically Unhealthy Status

Antioxidants ◽  
2020 ◽  
Vol 9 (7) ◽  
pp. 618
Author(s):  
Azahara I. Rupérez ◽  
María D. Mesa ◽  
Augusto Anguita-Ruiz ◽  
Esther M. González-Gil ◽  
Rocío Vázquez-Cobela ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Linear Models ◽  
Metabolic Diseases ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Endothelial Damage ◽  
Normal Weight ◽  
Oxidative Stress Biomarkers ◽  
Stress Biomarkers ◽  
And Oxidative Stress

Oxidative stress could help explain the relationship between childhood obesity and a metabolically unhealthy (MU) status. Moreover, puberty could also influence this relationship, since it entails physiological cardiometabolic changes. We aimed to evaluate plasma antioxidants and oxidative stress biomarkers in MU and metabolically healthy (MH) prepubertal and pubertal children and their associations with pro-inflammatory and endothelial damage biomarkers, taking puberty into account. A total of 1444 Spanish children aged 3–17 years (48.9% males, 66% prepubertal, 47.1% with obesity) were recruited. Blood pressure, anthropometric and biochemical parameters were measured, and children were categorized as having a MU or MH status according to risk factors. Retinol, carotenes, tocopherols, total antioxidant capacity (TAC), oxidized low-density lipoprotein and selected pro-inflammatory and endothelial damage biomarkers were analyzed. General linear models adjusted for age, sex, recruitment center and body mass index, partial correlations and stepwise linear regressions were performed. Lower carotenes and tocopherols levels were found in MU than in MH children. Plasma TAC was lower in prepubertal and higher in pubertal children with obesity compared to normal-weight children. Antioxidants and oxidative stress biomarkers showed novel associations with several pro-inflammatory and endothelial damage biomarkers, with pubertal differences, supporting the importance of considering both the antioxidant and oxidative stress status and puberty in the prevention of metabolic diseases in childhood.

scholarly journals Relationship Between Oxygen Radical Absorbance Capacity (ORAC) Index, Body Composition and Blood Biochemical Markers in Overweight /Obese Compared to Normal Weight Subjects

2020 ◽  
Author(s):  
Zahra Madani ◽  
Maryam Moussavi Javardi ◽  
Abolghassem Djazayery ◽  
Majid Karandish ◽  
Ariyo Movahedi
Keyword(s):  
Oxidative Stress ◽  
Body Fat ◽  
Fasting Blood Glucose ◽  
Oxygen Radical ◽  
Normal Weight ◽  
The Body ◽  
Oxygen Radical Absorbance Capacity ◽  
Health Clinic ◽  
Case Group ◽  
Significant Difference

Abstract Background and aim: Obesity is an important preventable disease, which promotes the development of multiple chronic disorders by altering several factors including oxidative stress. Dietary antioxidants protect the body against oxidative stress. The purpose of this study was to evaluate the potential association of oxygen radical absorbance capacity (ORAC) index with obesity and its associated biochemical factors in adults. Methods: The present study was a cross-sectional study of 157 adult females and males in two groups of normal weight and overweight /obesity. General characteristics were registered and a 147-item food frequency questionnaire was completed for every participant. Thereafter, anthropometric measurements were conducted. Biochemical indices were obtained from the Electronic Health Clinic Database of science and Research branch of Islamic Azad University (SRBIAU) of Tehran, Iran. The amount of the dietary ORAC index was estimated using the data provided by the USDA Foods Table. Results: The results showed that there was a significant difference between the normal and overweight/obese groups in terms of weight, body mass index (BMI), waist to hip ratio (WHR), visceral fat level, body fat mass and body fat percentage (P=0.0001). Participants with normal weight consumed more fruits and vegetables than individuals in another group. Also, the dietary ORAC index in normal individuals was higher than the case group, but there was not significant difference (P=0.222). There was also a significant inverse correlation between dietary ORAC and BMI and WHR, whereas a significant positive correlation between dietary ORAC and plasma levels of HDL was observed (P<0.05). Conclusion: Our findings suggest that consumption of antioxidants from dietary sources is inversely associated with BMI and other measurements of adiposity, fasting blood glucose (FBG), triglyceride (TG), total Cholesterol (TC) and LDL in both groups. It seems that following a diet rich in antioxidants can counteract obesity and its associated comorbidities.

Textile industrial effluent induces mutagenicity and oxidative DNA damage and exploits oxidative stress biomarkers in rats

2016 ◽  
Vol 41 ◽  
pp. 180-186 ◽  
Author(s):  
Muhammad Furqan Akhtar ◽  
Muhammad Ashraf ◽  
Aftab Ahmad Anjum ◽  
Aqeel Javeed ◽  
Ali Sharif ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Oxidative Dna Damage ◽  
Industrial Effluent ◽  
Oxidative Stress Biomarkers ◽  
Stress Biomarkers

Hypothyroidism induces oxidative stress and DNA damage in breast

2021 ◽  
Author(s):  
Milena Simões Peixoto ◽  
Andressa de Vasconcelos e Souza ◽  
Iris Soares Andrade ◽  
Carolina de Carvalho el Giusbi ◽  
Caroline Coelho Faria ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Oxidative Stress ◽  
Dna Damage ◽  
Genomic Instability ◽  
Redox Balance ◽  
Ros Generation ◽  
Antioxidant Enzyme Activities ◽  
Oxidative Stress Biomarkers ◽  
Stress Biomarkers ◽  
Mcf10a Cells

Breast cancer and thyroid dysfunctions have been associated for decades. Although many studies suggest a biological correlation, the mechanisms linking these two pathologies have not been elucidated. Reactive oxygen species (ROS) can oxidize lipids, proteins, and DNA molecules and may promote tumor initiation. Hence, we aimed at evaluating the mammary redox balance and genomic instability in a model of experimental hypothyroidism. Female Wistar rats were treated with 0.03% methimazole for 7 or 21 days to evaluate ROS generation, antioxidant enzyme activities, and oxidative stress biomarkers, as well as genomic instability. After 7 days, lower catalase, GPx, and DUOX activities were detected in the breast of hypothyroid group compared to the control while the levels of 4-hydroxynonenal (HNE) were higher. In addition, hypothyroid group showed an increase in γH2Ax/H2Ax ratio. 21-days hypothyroid group had increased catalase and SOD activities, without significant differences between groups in the levels of oxidative stress biomarkers and DNA damage. TSH-treated MCF10A cells showed a higher extracellular, intracellular, and mitochondrial ROS production. Additionally, greater DNA damage was observed in these cells, demonstrated by a higher comet tail DNA percentage and increased 53BP1 foci. Finally, we found that TSH treatment was not able to alter cell viability. The Genome Cancer Atlas (TGCA) data showed that high TSHR expression is associated with more invasive breast cancer types. In conclusion, we demonstrate that oxidative stress and DNA damage in breast are early events of experimental hypothyroidism. Moreover, high TSH levels induce oxidative stress and genomic instability in mammary cells.

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