scholarly journals Antioxidants and Oxidative Stress in Children: Influence of Puberty and Metabolically Unhealthy Status

Antioxidants ◽  
2020 ◽  
Vol 9 (7) ◽  
pp. 618
Author(s):  
Azahara I. Rupérez ◽  
María D. Mesa ◽  
Augusto Anguita-Ruiz ◽  
Esther M. González-Gil ◽  
Rocío Vázquez-Cobela ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Linear Models ◽  
Metabolic Diseases ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Endothelial Damage ◽  
Normal Weight ◽  
Oxidative Stress Biomarkers ◽  
Stress Biomarkers ◽  
And Oxidative Stress

Oxidative stress could help explain the relationship between childhood obesity and a metabolically unhealthy (MU) status. Moreover, puberty could also influence this relationship, since it entails physiological cardiometabolic changes. We aimed to evaluate plasma antioxidants and oxidative stress biomarkers in MU and metabolically healthy (MH) prepubertal and pubertal children and their associations with pro-inflammatory and endothelial damage biomarkers, taking puberty into account. A total of 1444 Spanish children aged 3–17 years (48.9% males, 66% prepubertal, 47.1% with obesity) were recruited. Blood pressure, anthropometric and biochemical parameters were measured, and children were categorized as having a MU or MH status according to risk factors. Retinol, carotenes, tocopherols, total antioxidant capacity (TAC), oxidized low-density lipoprotein and selected pro-inflammatory and endothelial damage biomarkers were analyzed. General linear models adjusted for age, sex, recruitment center and body mass index, partial correlations and stepwise linear regressions were performed. Lower carotenes and tocopherols levels were found in MU than in MH children. Plasma TAC was lower in prepubertal and higher in pubertal children with obesity compared to normal-weight children. Antioxidants and oxidative stress biomarkers showed novel associations with several pro-inflammatory and endothelial damage biomarkers, with pubertal differences, supporting the importance of considering both the antioxidant and oxidative stress status and puberty in the prevention of metabolic diseases in childhood.

scholarly journals Oxidative Stress Biomarkers and Left Ventricular Hypertrophy in Children with Chronic Kidney Disease

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Dorota Drożdż ◽  
Przemko Kwinta ◽  
Krystyna Sztefko ◽  
Zbigniew Kordon ◽  
Tomasz Drożdż ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Kidney Disease ◽  
Left Ventricular Hypertrophy ◽  
Ventricular Hypertrophy ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Left Ventricular ◽  
Low Density ◽  
Oxidative Stress Biomarkers ◽  
Stress Biomarkers

Cardiovascular diseases remain the most frequent cause of morbidity and mortality in patients with chronic kidney disease (CKD). The aim of the study was to assess the association between oxidative stress biomarkers and cardiovascular risk factors and left ventricular hypertrophy in children with CKD.Material and Methods. The studied group consisted of 65 patients aged 1.4–18.6 (mean 11.2) years with stages 1 to 5 CKD. Serum oxidized low-density lipoprotein (oxLDL), protein carbonyl group, creatinine, cystatin C, albumin, lipids, high-sensitivity C-reactive protein, intercellular adhesion molecule-1, insulin, plasma renin activity, and aldosterone levels were measured. Patients were divided into groups depending on CKD stage. Anthropometric measurements, ambulatory blood pressure (BP) measurements, and echocardiography with left ventricular mass (LVM) calculation were performed.Results. Serum oxLDL strongly correlated with creatinine (R=0.246;p=0.048), cystatin C (R=0.346;p=0.006), total cholesterol (R=0.500;p<0.001), triglycerides (R=0.524;p<0.001), low-density lipoprotein concentrations (R=0.456;p<0.001), and 24 hour BP values of systolic (R=0.492;p=0.002), diastolic (R=0.515;p<0.001), and mean arterial pressure (R=0.537;p<0.001). A significant correlation between oxLDL levels and LVMz-scores (R=0.299;p=0.016) was found.Conclusions. Hypertension and dyslipidemia correlated with lipid oxidation in children with CKD. oxLDLs seem to be valuable markers of oxidative stress in CKD patients, correlating with left ventricular hypertrophy.

scholarly journals Association of Lipids with Oxidative Stress Biomarkers in Subclinical Hypothyroidism

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Adriana Santi ◽  
Marta M. M. F. Duarte ◽  
Charlene C. de Menezes ◽  
Vania Lucia Loro
Keyword(s):  
Oxidative Stress ◽  
Subclinical Hypothyroidism ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Thiobarbituric Acid ◽  
Lipoprotein Cholesterol ◽  
Control Group ◽  
Oxidative Stress Biomarkers ◽  
Stress Biomarkers ◽  
Sh Group

Objective. The aim of the present study was to evaluate the oxidative stress biomarkers in patients with subclinical hypothyroidism (n=20) and health controls (n=20).Subjects and Methods. Total cholesterol (TC), triglycerides (TGs), low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), thiobarbituric acid reactive substances (TBARSs), catalase (CAT), superoxide dismutase (SOD), and arylesterase (ARE) were analyzed.Results. TC, LDL-C, TBARS, and CAT were higher in subclinical hypothyroidism patients, whereas SOD did not change. Arylesterase activity was significantly lower in the SH group, compared with the control group. Correlation analyses revealed the association of lipids (TC and LDL-C) with both oxidative stress biomarkers and thyrotropin (TSH). Thyroid hormones were correlated only with triglyceride levels. In addition, TSH was significantly correlated with TBARS, CAT, and SOD. However, no significant correlations were observed after controlling TC levels.Conclusions. We found that SH patients are under increased oxidative stress manifested by reduced ARE activity and elevated lipoperoxidation and CAT activity. Secondary hypercholesterolemia to thyroid dysfunction and not hypothyroidismper seappears to be associated with oxidative stress in subclinical hypothyroidism.

Could resistant starch supplementation improve inflammatory and oxidative stress biomarkers and uremic toxins levels in hemodialysis patients? A pilot randomized controlled trial

2018 ◽  
Vol 9 (12) ◽  
pp. 6508-6516 ◽  
Author(s):  
Marta Esgalhado ◽  
Julie A. Kemp ◽  
Renata Azevedo ◽  
Bruna R. Paiva ◽  
Milena B. Stockler-Pinto ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Resistant Starch ◽  
Controlled Trial ◽  
Hemodialysis Patients ◽  
Uremic Toxins ◽  
Oxidative Stress Biomarkers ◽  
Randomized Controlled ◽  
Stress Biomarkers ◽  
And Oxidative Stress ◽  
Pilot Randomized Controlled Trial

Prebiotic-resistant starch supplementation may be a good strategy to reduce inflammation, oxidative stress and uremic toxins in CKD patients.

Caffeine impacts in the clam Ruditapes philippinarum: Alterations on energy reserves, metabolic activity and oxidative stress biomarkers

Chemosphere ◽  
2016 ◽  
Vol 160 ◽  
pp. 95-103 ◽  
Author(s):  
Diogo Cruz ◽  
Ângela Almeida ◽  
Vânia Calisto ◽  
Valdemar I. Esteves ◽  
Rudolf J. Schneider ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Metabolic Activity ◽  
Ruditapes Philippinarum ◽  
Energy Reserves ◽  
Oxidative Stress Biomarkers ◽  
Stress Biomarkers ◽  
And Oxidative Stress
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