scholarly journals Age-dependent expression of 5alpha-reductase and androgen receptors mRNA by the canine prostate

2009 ◽  
pp. 155-158
Author(s):  
F Shidaifat
Keyword(s):  
Mrna Expression ◽  
Androgen Receptors ◽  
Prostate Gland ◽  
Normal Growth ◽  
Prostate Hyperplasia ◽  
Reductase Gene ◽  
Significant Difference ◽  
Growth Requirement ◽  
Benign Prostate ◽  
Androgen Effect

The growth of the prostate gland is androgen-dependent. Testosterone is converted to the most potent dihydrotestosterone (DHT) by 5α-reductase within the prostate. Androgen interacts with androgen receptors (AR) to regulate normal growth of the prostate and has also been implicated in both the progression of benign prostate hyperplasia and prostate cancer. This study was conducted to compare the mRNA expression of AR and 5αreductase by the prostate gland from three age categories: immature, young-mature and old dogs. Quantitative gene expression was assessed by the real-time PCR and the results were expressed as a relative mRNA expression of the target gene. This study revealed that there was no significant difference in the mRNA expression of the AR gene by the prostate gland of immature, young and old dogs. In contrast, there is a highly significant (P<0.001) down-regulation in 5α-reductase gene by the prostate of young and old dogs as compared with immature dogs. However, there is no significant difference in mRNA expression of the 5α-reductase gene by the prostate gland from young and old dogs. This differential expression of AR and 5αreductase genes, which are involved in the regulation of androgen effect on prostate gland, might reflect an agedependent growth requirement of the gland for androgens.

scholarly journals ORIGINAL ARTICLE: A COMPREHENSIVE STUDY OF PROSTATIC LESIONS AND ITS PROSTATE-SPECIFIC ANTIGEN LEVELS IN ANATOMICAL PATHOLOGY INSTALLATION OF RSUD DR. SOETOMO, SURABAYA FROM YEAR 2014 TO 2016

2019 ◽  
Vol 19 (1) ◽  
pp. 35-41
Author(s):  
Izzan Khalidah Binti Muhamad ◽  
Anny Setijo Rahaju ◽  
Lukman Hakim
Keyword(s):  
High Risk ◽  
Cell Carcinoma ◽  
Benign Prostate Hyperplasia ◽  
Benign Lesion ◽  
Prostate Gland ◽  
Transitional Cell ◽  
Specific Antigen ◽  
Prostate Hyperplasia ◽  
Benign Prostate ◽  
Anatomical Pathology

Abstract. Background: Diseases primarily affects prostate gland are inflammation, hyperplasia, and malignant tumour. Gleason score (GS) is an essential facet and together with PSA are substantial in diagnosing, managing, and determining the prognosis of CaP. Purpose: The aims of this study is to investigate the prevalence of prostatic lesions and its PSA level among patients in anatomical pathology installation in RSUD Dr. Soetomo from year 2014 to 2016. Method: This research is a retrospective study of prostatic lesions that were conducted from year 2014 to 2016 (3 years) with emphasis on GS and PSA levels. Result: The distribution of histopathological lesion found are benign lesion, benign prostate hyperplasia, adenocarcinoma, prostatitis, benign prostate hyperplasia with prostatitis, prostatic intraepithelial neoplasia, non-Hodgkin lymphoma, sarcoma, transitional cell carcinoma, and squamous cell carcinoma. The most common findings in this cohort is benign lesion (34.6%) with age group of 61-70 years old (51.94%) and adenocarcinoma with high GS of 9 (60%). Meanwhile, patients with GS ­8 (high risk patient) contributed for 84.8%. Most of the cases (69.2%) have elevated PSA level of 20 ng/ml. Conclusion: The prevalence of prostatic lesions were able to be determined in different age groups. High GS indicates a more aggressive type of adenocarcinoma suffered, high risk for CaP.  The results show that the possibility to detect malignancy with rising PSA level are higher, although PSA is not considered as a specific marker.Keywords: prostate, histopathology, benign lesion, PSA.

scholarly journals Effect of Tiger Nut Meal on PSA, Relative Organ Weight Sperm Cell and Histological Changes in Androgen-induced Benign Prostate Hyperplasia in Adult Male Wistar Rats

2020 ◽  
pp. 1-10
Author(s):  
D. I. Izunwanne ◽  
J. N. Egwurugwu ◽  
C. L. Emegano
Keyword(s):  
Benign Prostate Hyperplasia ◽  
Relative Weight ◽  
Organ Weight ◽  
Male Rats ◽  
Histological Changes ◽  
Prostate Hyperplasia ◽  
Morphological Studies ◽  
Significant Difference ◽  
Relative Organ Weight ◽  
Benign Prostate

Introduction: It is generally believed that Cyperus esculentus (tiger nut) has some fertility boosting effects. However, scientific validation of some the fertility boosting belief concerning tiger nut is lacking. Objective: The aim of this project was to study the effects of tiger nuts on PSA, Sperm midpiece, relative organ weight and histological changes in BPH induced rats. Method: A total of sixty (60) male rats weighing between 160 – 200 g were used in this study. They were divided into six groups of ten rats per group. Benign prostate hyperplasia was induced in three groups of the rats (as stated in methodology) with 30 mg/kg sub-cutaneous injections of hormones containing dihydrotestosterone (DHT) and estradiol valerate dissolved in olive oil in the ratio of 10:1 (three times in a week, one day interval). Administration of tiger nut meal commenced immediately and lasted for two months. At the end of administration, blood sample was collected from the rat via cardiac puncture for the determination of PSA. Semen sample was also collected for semen morphological studies. Internal organs notably, the prostate and the testes of the rats were also removed for histological examination. Results: The study showed that the induction of BPH brought about some adverse effects. On PSA, the administration of the tiger nut meal ameliorated the BPH by significantly reducing the increased level of the PSA which is a biomarker for prostate hyperplasia (P<0.05). The effect of the tiger nut on sperm morphological toxicities were also examined. Sperm abnormalities like those with bent midpiece was examined. The result showed that the administration of tiger nut meal significantly ameliorated the abnormality and thus, restored the morphology of the sperm cells such that it can enhance fertility. A significant difference was also seen in the relative weight of the prostate. The enlarged prostate in the induced + treated group was later observed through histological studies to have reduced significantly following the administration of the tiger nut. Conclusion: Tiger nut meal ameliorates BPH by reducing the PSA and enlarged prostate. It also ameliorates semen toxicities in the BPH induced + treated rats.

scholarly journals Percutaneous or Transurethral Cystolithotomy for Bladder Lithiasis: Which is Safer?

2019 ◽  
Vol 36 (1-2) ◽  
pp. 17-22
Author(s):  
Joao Pimentel Torres ◽  
Vítor Fernandes ◽  
Nuno Morais ◽  
Sara Anacleto ◽  
Paulo Mota ◽  
...  
Keyword(s):  
Hospital Stay ◽  
Prostate Hyperplasia ◽  
Median Hospital Stay ◽  
Urethral Strictures ◽  
Previous Diagnosis ◽  
Urethral Trauma ◽  
Significant Difference ◽  
Benign Prostate ◽  
Median Hospital

Introduction: Although the risk of urethral trauma while treating bladder stones is worrisome, evidence about the best treatment approach is scarce. The aim of this study is to compare the safety and efficacy of transurethral cystolithotomy and percutaneous suprapubic cystolithotomy in adults´ bladder lithiasis treatment. Methods: We retrospectively evaluated 120 patients (January 2012 to December 2017) who were surgically treated for bladder lithiasis with percutaneous suprapubic cystolithotomy (n= 20) and transurethral cystolithotomy (n= 100). Age, gender, calculi size, surgery duration, hospital stay, post-operative infections, haematuria, pain and urethral strictures were evaluated. Previous diagnosis of benign prostate hyperplasia and urethral strictures were also considered. Results: Both groups were homogeneous according to the pre-operative variables evaluated, including calculi dimensions and simultaneous diagnosis. Median surgery time in percutaneous suprapubic cystolithotomy and transurethral cystolithotomy were 65 and 58 minutes, respectively (p= 0.043). Pain and haematuria were similar in both groups. Median hospital stay was 2.0 days in both groups. Median follow-up time was 13 months. In the transurethral cystolithotomy, three patients (3%) developed urethral stricture while none of the patients treated with PSC developed urethral strictures during the follow-up (p= 0.435). Discussion: Percutaneous suprapubic cystolithotomy theoretically offers an advantage over transurethral cystolithotomy in terms of urethral trauma, although we did not observe a significant difference. However, it deserves to be considered, especially in patients with known urethral strictures that may hinder transurethral access. Further prospective studies with more patients may however confirm these theoretical advantages.

scholarly journals Effects of hyperprolactinemia on rat prostate growth: evidence of androgeno-dependence

2001 ◽  
Vol 280 (1) ◽  
pp. E120-E129 ◽  
Author(s):  
Fabien Van Coppenolle ◽  
Christian Slomianny ◽  
Françoise Carpentier ◽  
Xuefen Le Bourhis ◽  
Ahmed Ahidouch ◽  
...  
Keyword(s):  
Hormonal Regulation ◽  
Prostate Gland ◽  
In Vivo Model ◽  
Histological Changes ◽  
Prostate Hyperplasia ◽  
Prostate Development ◽  
Rat Prostate ◽  
Prostate Growth ◽  
Benign Prostate

The effects of the polypeptide hormone prolactin (PRL) in the development and regulation of benign prostate hyperplasia (BPH) and also in prostate cancer are not very well characterized. This study examines the action of PRL, either alone or in association with androgens [testosterone (T) or dihydrotestosterone (DHT)], in the rat prostate gland. The effects of PRL and androgens were investigated after 30 and 60 days in control, castrated, castrated with a substitutive implant of T or DHT, and sham-operated Wistar rats. To enhance PRL release, we induced hyperprolactinemia by administering chronic injections of sulpiride (40 mg · kg−1 · day−1). Chronic hyperprolactinemia induces enlargement and inflammation of the lateral rat prostate without any histological changes on ventral and dorsal lobes. We also demonstrate that hyperprolactinemia induces Bcl-2 overexpression in the lateral rat prostate and that this could inhibit the level of apoptosis. The in vivo model established here is a useful in vivo approach for studying the hormonal regulation of normal and pathological prostate development.

scholarly journals Modern approaches to surgical and minimally invasive treatment of patients with benign prostate hyperplasia

2020 ◽  
pp. 114-124
Author(s):  
A. A. Zimichev ◽  
D. O. Gusev ◽  
A. S. Pochivalov ◽  
P. V. Sumsky ◽  
I. V. Tarasov ◽  
...  
Keyword(s):  
Minimally Invasive ◽  
Conservative Therapy ◽  
Benign Prostate Hyperplasia ◽  
Prostate Gland ◽  
Minimally Invasive Treatment ◽  
Invasive Treatment ◽  
Prostate Hyperplasia ◽  
Surgical Interventions ◽  
Benign Prostate ◽  
Urological Diseases

Adenoma of the prostate gland is one of the most common urological diseases among males. The percentage of those suffering from BPH increases in direct proportion to the age of the patients. Despite the high study of the etiology, pathogenesis and manifestations of this disease, it is not always possible to achieve the desired effect using conservative therapy. Taking into account the middle age of the majority of patients dealing  with  this  problem, the presence of a number of concomitant diseases, if there is a technical  feasibility, priority is given to the least traumatic surgical interventions. The literature review analyzes the existing approaches to surgical and minimally invasive treatment of patients with benign prostatic hyperplasia.

scholarly journals Studi Literatur Perbedaan Ekspresi Messenger Ribonucleid Acid (mRNA) Reseptor Androgen Setelah Pemberian Testosteron antara Penis dan Kelenjar Prostat Tikus Wistar Jantan (Rattus Norvegicus) Pascakastrasi

2019 ◽  
Vol 6 (1) ◽  
pp. 29
Author(s):  
Luh Ari Arini
Keyword(s):  
Androgen Receptor ◽  
Mrna Expression ◽  
Androgen Receptors ◽  
Prostate Gland ◽  
Reproductive Organ ◽  
Target Organ ◽  
Normal Prostate ◽  
Receptor Mrna ◽  
Male Reproductive Organ ◽  
The Difference

Background: Aging process (andropause) in men will cause a decrease in testosterone hormones, in other that decrese of androgen receptor (testosteron and dhyhidrtestosterone) in target organ, can be seen from AR mRNA expression. Andropause finaly impact of male reproductive organ, so given testosterone hormone therapy is important to restore the condition. Giving testosterone hormone causes increase the expression of AR mRNA in the prostate gland and penis, but in these two organs there is a different increase.Objective: to know the difference of expression AR mRNA after administration of testosterone between prostate gland and penis.Method: This article used literature review from database of intisari sains medis.Results and Discussion: AR mRNA expression in the prostate gland is smaller than the penile tissue, due to the prostate gland in addition to the 5α reductase enzyme there are also many aromatase enzymes. In the normal prostate gland the amount of 5α reductase is small, so the addition of testosterone is converted to DHT but also in aromatization to estrogen. Therefore, fewer androgen receptors are found compared to the tissue of the penis, in addition expression of AR mRNA in the preputial penis is higher than the prostate gland.Conclusion: Penile tissue is more responsive to testosterone and improves the function and maintenance of tissue especially in old. Keywords: androgen receptor mRNA; testosterone; penis and prostate

scholarly journals Nocturia and benign prostatic hyperplasia

2008 ◽  
Vol 65 (10) ◽  
pp. 751-754
Author(s):  
Darko Laketic ◽  
Vesna Laketic
Keyword(s):  
Benign Prostate Hyperplasia ◽  
Control Group ◽  
Favorable Result ◽  
Prostate Hyperplasia ◽  
Factors Associated ◽  
Significant Difference ◽  
Before And After ◽  
Bothersome Symptom ◽  
Group A ◽  
Benign Prostate

Background/Aim. Nocturia often occurs in patients with benign prostate hyperplasia (BPH). The aim of the study was to investigate the frequency of nocturia in patients with BPH. Nocturia and other factors associated with it were also investigated. Methods. Forty patients with the confirmed diagnosis of BPH were studied. Transurethral and transvesical prostatectomy were performed in all the patients. Symptoms were evaluated with the International Prostate Symptom Score before, as well as three and six months after the surgery. All the results were compared with the control group. Results. There was no statistically significant difference between the patients before and after the surgery regarding nocturia. There was, however, a statistically significant difference between the operated patients and the control group regarding nocturia, as well as a statistically significant correlation between noctruia and the age of the patients in both the investigated and the control group. A correlation also existed between nocturia and the prostatic size. Conclusion. There was no statistically significant improvement in symptoms of nocturia after the surgery. It is necessary to be very careful in decision making in patients with nonabsolute indiction for surgery and isolated bothersome symptom of nocturia. Age of a patient should also be considered in the evaluation of favorable result of the surgery because of a significant correlation between noctura and the age of a patient.

Real-time quantitative RT-PCR assessment of PIM-1 and hK2 mRNA expression in benign prostate hyperplasia and prostate cancer

2008 ◽  
Vol 26 (3) ◽  
pp. 303-308 ◽  
Author(s):  
Hui-chan He ◽  
Xue-cheng Bi ◽  
Zhi-wei Zheng ◽  
Qi-shan Dai ◽  
Zhao-Dong Han ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Mrna Expression ◽  
Real Time ◽  
Benign Prostate Hyperplasia ◽  
Rt Pcr ◽  
Prostate Hyperplasia ◽  
Benign Prostate

scholarly journals Literature Review : Pengaruh Tekhnik Relaksasi Benson Terhadap Nyeri Pada Pasien Post Operasi Benigna Prostat Hyperplasia

2021 ◽  
Vol 1 ◽  
pp. 1274-1279
Author(s):  
Andi Muhamad Wildan ◽  
Tri Sakti Wirotomo ◽  
Siti Rofiqoh
Keyword(s):  
Literature Review ◽  
Benign Prostate Hyperplasia ◽  
Prostate Gland ◽  
Google Scholar ◽  
Relaxation Technique ◽  
P Value ◽  
Prostate Hyperplasia ◽  
Patient Will ◽  
Benign Prostate ◽  
Progressive Enlargement

AbstractBenign Prostatic Hyperplasia (BPH) is a progressive enlargement of the prostate gland that can be treated surgery, As a result of the surgery, the patient will usually feel pain. To overcome it, Benson’s relaxation technique could be applied. This relaxation is an action to free mentally and physically from tension and stress so that it can increase tolerance to pain. This study aims to examine the effect of Benson’s relaxation technique on pain in patients with postoperative benign prostate hyperplasia. Since it is a literature review, it has reviewed three articles taken from Google scholar with Benson’s relaxation, pain, and postoperative BPH as the keywords. Those articles are full-text, published in 2010-2020. The result stated the average vaule of pain scalee was 6,24 before the treatment and it reduced into 2,07 after it, with the p-value 0,000. It proved the therapy has effectively reduced oain in patients with postoperative benign prostate hyperplasia. Thus, nurses suggested applying this therapy as an alternative to reduce the problem.Keywords: Benson’s relaxation, pain, postoperative benign prostate hyperplasia AbstrakBenigna Prostat Hyperplasia (BPH) adalah pembesaran progresif dari kelenjar prostat yang dapat diatasi dengan tindakan pembedahan. Akibat dari pembedahan dapat menimbulkan nyeri. Pananganan nyeri salah satunya dengan relaksasi benson. Relaksasi Benson merupakan suatu tindakan untuk membebaskan mental dan fisik dari ketegangan dan stress sehingga dapat meningkatkan toleransi terhadap nyeri. Penelitian ini bertujuan untuk menggambarkan pengaruh teknik relaksasi benson terhadap penurunan nyeri post operasi BPH berdasarkan literature review. Desain karya tulis ilmiah berupa literature review dengan jumlah tiga artikel yang diambil dari laman google scholar dengan kata kunci “relaksasi benson, nyeri, post operasi BPH,” berupa artikel fulltex, terbit tahun 2010-2020. Hasil dari tiga artikel menujukkan nilai rata-rata skala nyeri sebelum intervensi 6,24 setelah intervensi 2,07 dengan p-value 0,000. Simpulan Terapi Relaksasi Benson efektif untuk menurunkan nyeri pasien post operasi BPH. Saran kepada perawat diharapkan dapat memberikan Teknik Relaksasi Benson sebagai alternatif untuk menurunkan nyeri pada pasien post operasi BPH.Kata kunci: Relaksasi Benson, Nyeri, Post Operasi BPH.

scholarly journals Association between Hyperglycemia and Prostate Volume in Patients with Benign Prostate Enlargement : A Hospital Case-Control Study

2017 ◽  
Vol 3 (2) ◽  
pp. 46
Author(s):  
Eriawan Agung Nugroho ◽  
Rickky Kurniawan
Keyword(s):  
Benign Prostate Hyperplasia ◽  
Prostate Volume ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Prostate Hyperplasia ◽  
Increased Risk ◽  
Prostate Enlargement ◽  
Significant Difference ◽  
Spearman Test ◽  
Benign Prostate

Introduction: Prostate is a male organ which might enlarge mostly, either benign or malignant. Hyperglycemia is one of the factor that increase the risk of  benign prostate hyperplasia. There is lack of studies which assessed the relationship between benign prostate hyperplasia and isolated hyperglycemia. The aim of this study was to evaluate the association between hyperglycemia and prostate volume in patients with benign prostate enlargement in dr. Kariadi Hospital Semarang.  Method: We conducted a retrospective analysis of clinical data which obtained from 640 men between 2010 and 2012 who admitted to the hospital with diagnosis of benign prostate enlargement. By their medical records, these patients were evaluated of their plasma glucose level and prostate volume by trans rectal ultrasound. The  presence  of  hyperglycemia  was  determined  based  on  the  American  Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Patients have already been diagnosed with controlled diabetes mellitus by an internist. We allocated the subjects into two groups: patients with hyperglycemia and non-hyperglycemia. Logistic regression analysis was used to assess whether hyperglycemia was associated with the increased risk of benign prostate enlargement.Results: Significant difference of prostate volume found between groups. Prostate volume was  significantly greater in hyperglycemia group compared with non-hyperglycemia ones in all sub-groups based on age (in decades). Odds Ratio (OR) in patients with hyperglycemia was 2.25 (95% CI: 1.23-4.11). By non-parametric Spearman test it obtained  Group 1 (P1) p = 0.000 and r = 0.669, group 2 (P2) it obtained p = 0.000 and r = 0.672, group 3 (P3) it obtained p = 0.000 and r = 0.415 which implied strong positive associationConclusion: Hyperglycemia and prostate volume were significantly associated in patients with benign prostate enlargement. Hyperglycemia became a significant risk factor  for  prostate  enlargement  in  patients  with  benign  prostate  enlargement  in dr. Kariadi Hospital Semarang.

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