scholarly journals Predictive Factors of Death in Neonates with Hypoxic Ischemic Encephalopathy Receiving Selective Head Cooling

2020 ◽  
Author(s):  
Behnaz Basiri ◽  
Mohammadkazem Sabzehei ◽  
Mohammadmahdi sabahi
Keyword(s):  
Predictive Factors ◽  
Hypoxic Ischemic Encephalopathy ◽  
Head Cooling ◽  
Ischemic Encephalopathy

Planned home birth and the association with neonatal hypoxic ischemic encephalopathy

2017 ◽  
Vol 45 (9) ◽  
Author(s):  
Shane W. Wasden ◽  
Stephen T. Chasen ◽  
Jeffrey M. Perlman ◽  
Jessica L. Illuzzi ◽  
Frank A. Chervenak ◽  
...  
Keyword(s):  
Mode Of Delivery ◽  
Birth Certificate ◽  
Home Birth ◽  
Hypoxic Ischemic Encephalopathy ◽  
Hospital Birth ◽  
Head Cooling ◽  
Vital Records ◽  
Planned Home Birth ◽  
Ischemic Encephalopathy ◽  
Normal Controls

AbstractObjective:To evaluate the association between planned home birth and neonatal hypoxic ischemic encephalopathy (HIE).Methods:This is a case-control study in which a database of neonates who underwent head cooling for HIE at our institution from 2007 to 2011 was linked to New York City (NYC) vital records. Four normal controls per case were then randomly selected from the birth certificate data after matching for year of birth, geographic location, and gestational age. Demographic and obstetric information was obtained from the vital records for both the cases and controls. Location of birth was analyzed as hospital or out of hospital birth. Details from the out of hospital deliveries were reviewed to determine if the delivery was a planned home birth. Maternal and pregnancy characteristics were examined as covariates and potential confounders. Logistic regression was used to determine the odds of HIE by intended location of delivery.Results:Sixty-nine neonates who underwent head cooling for HIE had available vital record data on their births. The 69 cases were matched to 276 normal controls. After adjusting for pregnancy characteristics and mode of delivery, neonates with HIE had a 44.0-fold [95% confidence interval (CI) 1.7–256.4] odds of having delivered out of hospital, whether unplanned or planned. Infants with HIE had a 21.0-fold (95% CI 1.7–256.4) increase in adjusted odds of having had a planned home birth compared to infants without HIE.Conclusion:Out of hospital birth, whether planned home birth or unplanned out of hospital birth, is associated with an increase in the odds of neonatal HIE.

scholarly journals Regression of cystic lesions on brain MRI in a child with hypoxic-ischemic encephalopathy treated with selective head cooling

2013 ◽  
Vol 84 (2) ◽  
Author(s):  
Elżbieta Szczepanik ◽  
Maria Borszewska-Kornacka ◽  
Dorota Antczak-Marach ◽  
Monika Bekiesińska-Figatowska
Keyword(s):  
Brain Mri ◽  
Hypoxic Ischemic Encephalopathy ◽  
Cystic Lesions ◽  
Head Cooling ◽  
Ischemic Encephalopathy

scholarly journals Early Biomarkers and Hearing Impairments in Patients with Neonatal Hypoxic–Ischemic Encephalopathy

Diagnostics ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 2056
Author(s):  
Da-Yang Chen ◽  
Inn-Chi Lee ◽  
Xing-An Wang ◽  
Swee-Hee Wong
Keyword(s):  
Blood Lactate ◽  
Predictive Factors ◽  
Serum Glucose ◽  
Hypoxic Ischemic Encephalopathy ◽  
Clinical Staging ◽  
Hearing Impairments ◽  
Neurodevelopmental Outcomes ◽  
Glucose Levels ◽  
Brain Anomalies ◽  
Ischemic Encephalopathy

Identifying biomarkers for hearing impairments (HIs) in patients with neonatal hypoxic–ischemic encephalopathy (HIE), to initialize early hearing habilitation, is crucial. Seventy-eight neonates with HIE were divided into the following two groups: those with HIs and those without HIs. We compared those patients with 11,837 newborns without HIE, and analyzed the risk factors of HIs among neonatal HIE. Of the 78 patients, 11 were confirmed to have an HI, which is a substantially higher percentage than in the 11,837 newborns without HIE (14.1% vs. 0.87%; p < 0.001). More patients with moderate-to-severe HIE had confirmed HIs (p = 0.020; odds ratio, 8.61) than those with mild HIE. Clinical staging, and blood lactate and glucose levels could be predictive factors for HIs among patients with HIE. The patients who exhibited HIs had significantly higher lactate (104.8 ± 51.0 vs. 71.4 ± 48.4; U = 181, p = 0.032) and serum glucose (159.5 ± 86.1 vs. 112.1 ± 62.3; U = 166, p = 0.036) levels than those without HIs. A higher prevalence of HIs was noted in the patients with stage III HIE than those with stage II HIE (43.8% vs. 10%; p = 0.008). The degree of HI correlated with brain anomalies and neurodevelopmental outcomes at 1 year of age. Clinical staging, and blood lactate and glucose levels could be predictive factors for HIs among patients with HIE.

Selective head cooling and acute kidney injury in neonates with hypoxic ischemic encephalopathy

2020 ◽  
Vol 13 (1) ◽  
pp. 21-30
Author(s):  
I. Nour ◽  
R. Elmaghraby ◽  
R. Shehata ◽  
A. El-Refaey ◽  
H. Aldomiaty ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Hypoxic Ischemic Encephalopathy ◽  
Head Cooling ◽  
Ischemic Encephalopathy

scholarly journals Comparison of selective head cooling therapy and whole body cooling therapy in newborns with hypoxic ischemic encephalopathy: Short term results

2015 ◽  
Vol 50 (1) ◽  
pp. 27-36 ◽  
Author(s):  
Aytug Atici ◽  
Yalcin Celik ◽  
Selvi Gulasi ◽  
Ali Haydar Turhan ◽  
Cetin Okuyaz ◽  
...  
Keyword(s):  
Hypoxic Ischemic Encephalopathy ◽  
Whole Body ◽  
Short Term ◽  
Head Cooling ◽  
Body Cooling ◽  
Whole Body Cooling ◽  
Ischemic Encephalopathy

scholarly journals Application of simple head cooling combined with gangliosides in neonatal hypoxic-ischemic encephalopathy

2021 ◽  
Vol 2 (2) ◽  
Author(s):  
Zhen Zhan ◽  
Huanhuan Cheng ◽  
Xianhong Lin ◽  
Yangyang Meng ◽  
Liying Dai ◽  
...  
Keyword(s):  
Clinical Efficacy ◽  
Adverse Reactions ◽  
Clinical Symptoms ◽  
Clinical Performance ◽  
Hypoxic Ischemic Encephalopathy ◽  
Control Group ◽  
Observation Group ◽  
Head Cooling ◽  
Disturbance Of Consciousness ◽  
Ischemic Encephalopathy

Objective To investigate the effect of simple head cooling combined with ganglioside therapy on neonatal hypoxic-ischemic encephalopathy (HIE) and its clinical efficacy. Methods A total of 100 children with HIE admitted in the neonatal ward of our hospital from August 2018 to October 2020 were selected as the research objects, and were divided into control group and observation group according to the random number table method, with 50 cases in each group. The control group was treated with gangliosides, and the observation group was treated with simple head cooling combined with gangliosides. Observe and compare the clinical performance improvement time, the level of relevant hematological examination indexes before and after treatment, and the neonatal behavioral neurological assessment (NBNA), clinical efficacy, and adverse reactions. Results The improvement time of convulsions, disturbance of consciousness, pupil changes, hypotonia, and gastrointestinal dysfunction in the observation group was significantly lower than that in the control group (all P＜0.001). After treatment, the NSE, IL-6, CK, CK-MB of the two groups of children were significantly lower than before treatment, and the serum calcium and NBNA scores were significantly higher than before treatment, and the decrease or increase in the observation group was significantly higher than that of the control Group (all P＜0.001). The total effective rate of treatment of children in the observation group (82.00%) was higher than that of the control group (62.00%) (P<0.05). There were no obvious adverse reactions in both groups. Conclusion The simple head cooling combined with gangliosides in the treatment of HIE can improve the clinical symptoms, blood test index levels, and NBNA scores. The clinical effect is clear and superior to the single use of gangliosides.

Prediction of Future Epilepsy in Neonates With Hypoxic-Ischemic Encephalopathy Who Received Selective Head Cooling

2017 ◽  
Vol 32 (7) ◽  
pp. 630-637 ◽  
Author(s):  
Tiffani L. McDonough ◽  
Juliann M. Paolicchi ◽  
Linda A. Heier ◽  
Nikkan Das ◽  
Murray Engel ◽  
...  
Keyword(s):  
Risk Groups ◽  
Hypoxic Ischemic Encephalopathy ◽  
Sensitivity Analyses ◽  
Resonance Imaging ◽  
Head Cooling ◽  
Deep Gray Matter ◽  
Magnetic Resonance Imaging Mri ◽  
Electroencephalogram Eeg ◽  
Ischemic Encephalopathy

Epilepsy outcomes after therapeutic hypothermia for neonates with hypoxic-ischemic encephalopathy are understudied. The authors used multivariable logistic regression to predict epilepsy in neonates after selective head cooling. Sensitivity analyses used magnetic resonance imaging (MRI) and electroencephalogram (EEG) interpretations by different clinicians. Fifty neonates had 2-year follow-up. Nine developed epilepsy. Predictors included pH ≤6.8 on day of birth (adjusted odds ratio [OR] 19 [95% confidence interval (CI) 1-371]), burst suppression on EEG on day 4 (8.2 [1.3-59]), and MRI deep gray matter injury (OR 33 [2.4-460]). These factors stratify neonates into low (0-1 factors; 3% [0%-14%] risk), medium (2 factors; 56% [21%-86%] risk), and high-risk groups (3 factors; 100% [29%-100%] risk) for epilepsy. The stratification was robust to varying clinical interpretations of the MRI and EEG. Neonates with hypoxic-ischemic encephalopathy who undergo selective head cooling appear at risk of epilepsy if they have 2 to 3 identified factors. If validated, this rule may help counsel families and identify children for close clinical follow-up.

Sign in / Sign up

Export Citation Format

Share Document