scholarly journals Influence of Hibiscus sabdariffa (Gongura) on the levels of circulatory lipid peroxidation products and liver marker enzymes in experimental hyperammonemia

2006 ◽  
Vol 4 (1) ◽  
pp. 53-58 ◽  
Author(s):  
Musthafa Mohamed Essa ◽  
Perumal Subramanian ◽  
Ganapathy Suthakar ◽  
Tamilarasan Manivasagam ◽  
Kadiyala Babu Dakshayani ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Hibiscus Sabdariffa ◽  
Marker Enzymes ◽  
Liver Marker Enzymes ◽  
Lipid Peroxidation Products

scholarly journals Effect ofWithania SomniferaRoot Powder on the Levels of Circulatory Lipid Peroxidation and Liver Marker Enzymes in Chronic Hyperammonemia

2008 ◽  
Vol 5 (4) ◽  
pp. 872-877 ◽  
Author(s):  
B. Harikrishnan ◽  
P. Subramanian ◽  
S. Subash
Keyword(s):  
Lipid Peroxidation ◽  
Ammonium Chloride ◽  
Radical Scavenging ◽  
Thiobarbituric Acid ◽  
Underlying Mechanism ◽  
Antioxidant Property ◽  
Marker Enzymes ◽  
Liver Marker Enzymes ◽  
Lipid Peroxidation Products ◽  
Liver Markers

Withania somnifera(L) Dunal (Solanaceae), commonly called Ashwagandha (Sanskrit) is an Ayurvedic Indian medicinal plant, which has been widely used as a home remedy for several ailments. We have investigated the influence ofW.somniferaroot powder on the levels of circulatory ammonia, urea, lipid peroxidation products such as TBARS (thiobarbituric acid and reactive substances), HP (hydroperoxides) and liver marker enzymes such as AST (aspartate transaminase), ALT (alanine transaminase) and ALP (alkaline phosphatase), for its hepatoprotective effect in ammonium chloride induced hyperammonemia. Ammonium chloride treated rats showed a significant increase in the levels of circulatory ammonia, urea, AST, ALT, ALP, TBARS and HP. These changes were significantly decreased in rats treated withW.somniferaroot powder and ammonium chloride. Our results indicate thatW.somniferaoffers hepatoprotection by influencing the levels of lipid peroxidation products and liver markers in experimental hyperammonemia and this could be due to (i) the presence of alkaloids, withanolids and flavonoids, (ii) normalizing the levels of urea and urea related compounds, (iii) its free radical scavenging property and (iv) its antioxidant property. The exact underlying mechanism is still unclear and further research needed.

scholarly journals Biochemical Effects of the Aqueous Extract of Hibiscus sabdariffa on Liver Marker Enzymes and Lipid Profiles in Acetaminophen-challenged Rats

2017 ◽  
Vol 11 (2) ◽  
pp. 48-54
Author(s):  
Ukegbu Chimere Young ◽  
Joshua Parker Elijah ◽  
Eze Chuma ◽  
Nkwocha Chinenye Chinelo ◽  
Okafor Joshua Onyiagozir ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Lipid Profiles ◽  
Hibiscus Sabdariffa ◽  
Marker Enzymes ◽  
Liver Marker Enzymes ◽  
Biochemical Effects

scholarly journals Effects of methanolic calyx extract of Hibiscus sabdariffa on body weight, blood cholesterol and liver marker enzymes in Wistar rats

2018 ◽  
Vol 12 (26) ◽  
pp. 427-434 ◽  
Author(s):  
I. Nnamonu Emmanuel ◽  
C. Ejere Vincent ◽  
C. Mbegbu Edmund ◽  
S. Ezechukwu Chiemekam ◽  
O. Ejim Anthony
Keyword(s):  
Body Weight ◽  
Wistar Rats ◽  
Blood Cholesterol ◽  
Hibiscus Sabdariffa ◽  
Marker Enzymes ◽  
Liver Marker Enzymes

scholarly journals Antioxidant, anti-cancer and ameliorative activities of Spirulina platensis and pomegranate juice against hepatic damage induced by CCl4

2020 ◽  
Vol 48 (4) ◽  
pp. 1941-1956
Author(s):  
Hossam S. EL-BELTAGI ◽  
Faten DHAWI ◽  
Ihab S. ASHOUSH ◽  
Khaled RAMADAN
Keyword(s):  
Lipid Peroxidation ◽  
Spirulina Platensis ◽  
Antioxidant Status ◽  
Liver Homogenate ◽  
Water Extract ◽  
Pomegranate Juice ◽  
Total Phenolic ◽  
Liver Carcinoma ◽  
Marker Enzymes ◽  
Liver Marker Enzymes

Due to the excessive impact of synthetic drugs, unravelling and employing safe, natural alternatives are now needed to resolve a number of diseases. In this research, we have evaluated hepatoprotective and antioxidant activities of Spirulina platensis and pomegranate juice in rats against hepatotoxicity induced by carbon tetrachloride (CCl4). Spirulina crude carotenoid extract was screened by UPLC-MS / MS. Activities of liver marker enzymes; measured aspartate aminotransferase (AST) and alanine aminotransferase (ALT), and determined lipid peroxidation and antioxidant status as reduced glutathione (GSH) in liver homogenate. The infusion of CCl4 (2 ml/kg b.wt) greatly increases levels of liver marker enzymes and lipid peroxidation, resulting in depletion of antioxidants. Treatment of Spirulina platensis (Sp), pomegranate juice (Pj)or mixture (PJSP) of Spirulina water extract 10% and pomegranate juice 90% (1 ml/100 g b.wt) to CCl4-disrupted rats resulted in decreased activity of liver marker enzymes, lipid peroxidation with increased antioxidant status. Chromatographic separation showed that ß-carotene is the predominant carotenoid extract. This carotenoid extract was tested for colon carcinoma (HCT-116), liver carcinoma (HepG2) and intestinal carcinoma cell lines (CACO) LC50 for 21.8, 14 and 11.3 ug / ml, respectively. Total phenolic phytochemicals, total carotenoids and total flavonoids were also measured in Spirulina. Our study clearly demonstrates that Spirulina platensis and pomegranate juice had hepatoprotective effect on CCl4-caused hepatotoxicity in rats through its antioxidant activity.

scholarly journals PSVII-17 Program Chair Poster Pick: Reproductive function of cows depending on lipid metabolism

2020 ◽  
Vol 98 (Supplement_4) ◽  
pp. 293-294
Author(s):  
Murat Baymishev ◽  
Sergey Eremin ◽  
Kirill Plemyashov ◽  
Khamidulla Baymishev ◽  
Igor Konopel’tsev ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Live Weight ◽  
Reproductive Function ◽  
Serum Levels ◽  
Total Serum ◽  
Dry Period ◽  
Lipid Peroxidation Products ◽  
Synthetic Function ◽  
The Difference ◽  
Oxidized Products

Abstract The aim of the study was to determine the etiopathogenesis of reproductive dysfunction in highly productive cows. Studies were conducted on cows of black-motley breed, aged 3–5 lactations, with a live weight of 480–520 kg. Cows were divided into two groups. The first group included 20 cows effective inseminated after the first insemination. The second group included 17 cows that did not fertilize after the first insemination. Blood samples (n = 253) were taken from 4–7; 14–17; 24–34; 35–50; 88–95; 195–210 days of pregnancy; during the beginning of dry period (DP); 1–4 days before calving and on the first day after calving. The content of total serum lipids in pregnant animals was 15.8% higher compared to unfertilized animals. In non-pregnant cows, a decrease in free cholesterol (by 28.65%), especially in its ether-bound fraction (14.91%), indicates a lower synthetic function of the liver, which is confirmed by the low serum levels of vitamins A and E (a difference of 11.3 and 23.65%). The DP was characterized by a significant increase in the products of lipid peroxidation - malondialdehyde by 12–17%, diene and triene conjugates - by 10–15 and 8–15%, respectively, and 1–4 days before calving in cows, which subsequently had a pathological calving, in particular - retention of placenta (5 cows), were characterized by an increased content in the blood plasma of lipid peroxidation products. Thus, the difference in the number of dienes, trienes, and malondialdehyde products was 14.0, 12.0, and 23.5%, compared with animals without obstetric pathology. On the first day after calving, this difference increased even more. Cows with retention of placenta had a significantly higher level of lipid peroxidation products and were characterized by a predominance of oxidized products over the antiradical thiol disulfide and ascorbate systems restored in the antioxidant balance.

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