scholarly journals Chemistry and Biological Evaluation of Some New Triazolopyrimidine Derivatives Containing Isopropyl Group

2019 ◽  
pp. 390-396
Author(s):  
Janaki H. Chauhan ◽  
Haresh K. Ram
Keyword(s):  
Antifungal Activity ◽  
1H Nmr ◽  
Biological Evaluation ◽  
Spectroscopic Techniques ◽  
Efficient Synthesis ◽  
Antibacterial And Antifungal Activity ◽  
Isopropyl Group ◽  
Elemental Analyses ◽  
Antibacterial And Antifungal

An efficient Synthesis of a novel series of N,7-bis(substitutedphenyl)-4,7-dihydro-5-isopropyl-[1,2,4]triazolo-[1,5-a]pyrimidine-6-carboxamide (4a-j) was accomplished from N-(substituedphenyl)-4-methyl-3-oxopentanamide, 3-amino-1,2,4-triazole and different aldehyde reflex 20 min with DMF and then after the cooling product was obtained. All the recently synthesized compounds were characterized by the Mass, IR, 1H-NMR and mass spectroscopic techniques and by elemental analyses. The newly synthesized compounds were assessed for their antibacterial and antifungal activity.

scholarly journals Synthesis and biological Evaluation of Some Abbreviated New Triazolopyrimidines

2019 ◽  
pp. 354-361
Author(s):  
Jatin Vora ◽  
Kartik Vyas
Keyword(s):  
Biginelli Reaction ◽  
Biological Evaluation ◽  
Spectroscopic Techniques ◽  
The Novel ◽  
Antibacterial And Antifungal Activity ◽  
1H Nuclear Magnetic Resonance ◽  
Elemental Analyses ◽  
Antibacterial And Antifungal ◽  
Synthesis And Biological Evaluation ◽  
Compound Series

A cogent synthesis of completely new compound series of by 6-(3,5-bis(trifluoromethyl)phenyl)-4-(4-chlorophenyl)-3,4-dihydro pyrimidine-2(1H)-one (Biginelli reaction) was achieved by continue heating of (E)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(substituted phenyl)prop-2-en-1-one and urea for 5 hours with 40% KOH and ethyl alcohol. (E)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(substituted phenyl)prop-2-en-1-one is produced by Claisen-Schmidt Condensation. In this condensation 1-(3,5-bis(trifluoromethyl)phenyl)ethanone and different aldehyde are mixed. All the novel compound series were characterized by infrared and 1H nuclear magnetic resonance and mass spectroscopic techniques and by elemental analyses. The newly synthesized compounds were evaluated for their antibacterial and antifungal activity

scholarly journals Synthesis and Antimicrobial Evaluation of Some Condensed New Triazolopyrimidines

2019 ◽  
pp. 397-404
Author(s):  
Jatin Vora ◽  
Kartik Vyas
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Biginelli Reaction ◽  
Spectroscopic Techniques ◽  
Efficient Synthesis ◽  
Antibacterial And Antifungal Activity ◽  
1H Nuclear Magnetic Resonance ◽  
Elemental Analyses ◽  
Antimicrobial Evaluation ◽  
Antibacterial And Antifungal ◽  
Compound Series

An efficient synthesis of a novel compound series of 2-[3,5-bis(trifluoromethyl)phenyl]-4-(substitutedphenyl)-1,4-dihydropyrimido[1,2-a]benzimidazole (Biginelli reaction) was accomplished from (E)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(4-chlorophenyl)prop-2-en-1-one and 1H-benzo[d]imidazol-2-amine Microwave 25 minute heating after the product obtained another method Conventional 7 hrs, with 30 % KOH, Ethanol. Here (E)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(4-chlorophenyl)prop-2-en-1-one(Chalcone) is prepared by 1-(3,5-bis(trifluoromethyl)phenyl)ethanone and different aldehyde with Claisen-Schimidt Condensation.All the newly synthesized compounds were characterized by infrared and 1H nuclear magnetic resonance and mass spectroscopic techniques and by elemental analyses. The newly synthesized compounds were evaluated for their antibacterial and antifungal activity.

scholarly journals Synthesis of some new 6-aryl-3-(4-isopropylphenyl)[1,2,4]triazolo[3,4-b][1,3,4] thiadiazoles and its anti-microbial study

2021 ◽  
Vol 10 (4) ◽  
pp. 479-488 ◽  
Author(s):  
K. A. Joshi ◽  
J. M. Dhalani ◽  
H. B. Bhatt ◽  
K. M. Kapadiya
Keyword(s):  
Antifungal Activity ◽  
Spectroscopic Techniques ◽  
Aromatic Acids ◽  
Reference Standard ◽  
Antibacterial And Antifungal Activity ◽  
Essential Step ◽  
Step Procedure ◽  
Antibacterial And Antifungal ◽  
Microbial Study

New series of fused 1,2,4-triazoles, i.e., 3-(4-isopropylphenyl)-6-substituted phenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles (5a-5j) have been synthesized via a four-step procedure and using eco-friendly reaction condition at some steps of the synthesis. It was adopted by the formation of hydrazide of methyl 4-isopropylbenzoate (1) followed by reaction with CS2 in basic media to afford potassium salt, which on cyclized to our essential step, 4-amino-5-(4-isopropylphenyl)-4H-1,2,4-triazole-3-thiol (4). The desired adducts (5a-5j) were formed by (4) on reaction with various aromatic acids in POCl3 media. The newly synthesized triazolo- thiadiazoles have been characterized by different spectroscopic techniques and investigated for their in vitro antibacterial and antifungal activity. It was revealed that the compounds 5a, 5c, 5h, and 5i showed interesting antibacterial and antifungal activity compared to the used reference standard.

scholarly journals Dacrymenone and VM 3298-2 - New Antibiotics with Antibacterial and Antifungal Activity

2003 ◽  
Vol 58 (7-8) ◽  
pp. 541-546 ◽  
Author(s):  
Viktor Mierau ◽  
Timm Anke ◽  
Olov Sterner
Keyword(s):  
Antifungal Activity ◽  
Spectroscopic Techniques ◽  
Antibacterial And Antifungal Activity ◽  
Enol Ether ◽  
Antifungal Activities ◽  
New Antibiotics ◽  
Methyl Pyruvate ◽  
Antibacterial And Antifungal

Abstract Two new antibiotic metabolites, dacrymenone (1) and VM 3298-2 (2), were isolated from fermentations of a Dacrymyces sp., and their structures were determined by spectroscopic techniques. Dacrymenone (1) is a new eremophilane sesquiterpenoid while VM 3298-2 (2) is a bis-enol ether between methyl pyruvate and 4,6-dihydroxycyclohexan-1,3-dione. Dacrymenone (1) shows weak antibacterial and antifungal activity while VM 3298-2 (2) exhibits cytotoxic and antifungal activities.

scholarly journals Studies on Oligomer Metal Complexes Derived from Bisamic Acid of Pyromellitic Dianhydride and 4-Bromoaniline

2014 ◽  
Vol 2014 ◽  
pp. 1-7
Author(s):  
Yogesh S. Patel
Keyword(s):  
Antifungal Activity ◽  
Metal Complexes ◽  
Terephthalic Acid ◽  
Magnetic Measurement ◽  
Pyromellitic Dianhydride ◽  
Metal Salts ◽  
Spectroscopic Techniques ◽  
Antibacterial And Antifungal Activity ◽  
Transition Metal Salts ◽  
Antibacterial And Antifungal

Novel oligomer metal complexes (2a–f) of the ligand 2,5-bis((4-bromophenyl)carbamoyl) terephthalic acid (1) were prepared using transition metal salts and characterized by various spectroscopic techniques. The geometry of oligomer metal complexes was carried out by electronic spectral analysis and magnetic measurement studies. Polymeric properties have also been carried out. Ligand was synthesized using pyromellitic dianhydride and 4-bromoaniline. It was duly characterized. All novel synthesized compounds 1 and 2a–f were evaluated for their antibacterial and antifungal activity. The results showed significantly higher antibacterial and antifungal activity of oligomer metal complexes compared to the ligand.

Synthesis and Biological Evaluation of Chalconyl Incorporated Schiff’s Bases of Sulphonamides

2017 ◽  
Vol 8 (03) ◽  
Author(s):  
Neeraj Kumar ◽  
Dhruti Bhatt ◽  
Chandra Shekhar Sharma ◽  
Hamendra Pratap Singh ◽  
Harshda Pandiya ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Antifungal Activity ◽  
Biological Evaluation ◽  
Antibacterial And Antifungal Activity ◽  
Schiff’S Bases ◽  
E Coli ◽  
Schiff's Bases ◽  
Microbial Strains ◽  
Antibacterial And Antifungal ◽  
Synthesis And Biological Evaluation

A series of of Chalconyl Incorporated Schiff’s Bases of Sulphonamides was synthesized by reacting substituted chalcone derivatives with Sulphacetamide sodium in methanol. All the title compounds synthesized (2a-2d) were tested for antibacterial and antifungal activity using E. coli, P. aeruginosa, S. aureus, S. pyogenus and C. albicans, A. niger and A. clavatus respectively as microbial strains and Sulphacetamide sodium as standard. The compound 2d showed significant antibacterial activity and 2a showed moderate antifungal activity as compared with Sulphacetamide Sodium.

scholarly journals Synthesis and Biological Evaluation of Novel Schiff Bases of Aryloxy Moiety

2019 ◽  
Vol 9 (5-s) ◽  
pp. 44-49
Author(s):  
Purushottam R. Laddha ◽  
Kailash R. Biyani
Keyword(s):  
Acetic Acid ◽  
Antifungal Activity ◽  
Schiff Bases ◽  
Biological Activities ◽  
Biological Evaluation ◽  
Spectral Studies ◽  
Primary Amines ◽  
Antibacterial And Antifungal Activity ◽  
Phenoxy Acetic Acid ◽  
Antibacterial And Antifungal

Schiff's bases are condensation products of primary amines with carbonyl compounds. Schiff bases (imines) possess wide variety of biological activities that include antibacterial and antifungal activity. In present work, Schiff bases from 3,5- Dimethoxyphenol (aryloxy moiety) as starting material synthesized. Esterification of 3,5- Dimethoxyphenol led to formation of (3,5-Dimethoxy-phenoxy)-acetic acid ethyl ester (1). (3,5-Dimethoxy-phenoxy)-acetic acid hydrazide (2) is derived from Compound (1) by hydrazination. Compound (2) was reacted with different aromatic aldehydes to yield novel imines or Schiff bases (3A-I). The newly synthesized compounds were characterized on the basis of spectral studies and evaluated for antibacterial and antifungal activities. All the synthesized compounds had shown antibacterial and antifungal activity. Schiff bases 3C, 3D, 3E and 3I had shown good antimicrobial activity among all newly synthesized compounds. Keywords: Schiff base, aryloxy moiety, imines

scholarly journals Synthesis, spectroscopic and biological investigations of di-and triorganotin(IV) derivatives containing germanium: X-ray study of [Ph3GeCH(n-C3H7)CH2CO2]Sn[CH3]3

2006 ◽  
Vol 71 (10) ◽  
pp. 1001-1013 ◽  
Author(s):  
Muhammad Khosa-Kaleem ◽  
Muhammad Mazhar ◽  
Saqib Ali ◽  
Sarim Dastgir ◽  
Masood Parvez ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Antibacterial And Antifungal Activity ◽  
X Ray ◽  
Multinuclear Nmr ◽  
Trigonal Bipyramidal Geometry ◽  
Trigonal Bipyramidal ◽  
Elemental Analyses ◽  
Antibacterial And Antifungal ◽  
Distorted Trigonal Bipyramidal

Bimetallic di- and triorganotin(IV) germanium carboxylates were synthesized and characterized by elemental analyses, as well as IR, multinuclear NMR (1H, 13C, 119Sn) spectroscopy and tested for bioactivity. The structure of the representative compound, [Ph3GeCH(n-C3H7)CH2CO2]Sn[CH3]3, was determined by X-ray analysis and found to have a distorted trigonal bipyramidal geometry around the tin atom. Some selected compounds were also screened against different microbes and showed promising antibacterial and antifungal activity. .

Antimicrobial Activity of Some Novel 1-(3-(4-Chlorophenylimino)-3,4- dihydroquinoxalin-2-yl)-3-substituted phenyl-1H-pyrazole-4-carbaldehyde

2020 ◽  
Vol 18 (2) ◽  
pp. 128-134
Author(s):  
Dhanapal Visagaperumal ◽  
Vineeth Chandy
Keyword(s):  
Antimicrobial Activity ◽  
Antifungal Activity ◽  
Dilution Method ◽  
Significant Activity ◽  
Antibacterial And Antifungal Activity ◽  
Reference Drug ◽  
Mass Spectral ◽  
Diffusion Technique ◽  
Elemental Analyses ◽  
Antibacterial And Antifungal

Background: In this study, synthesis of some novel 1-(3-(4-chlorophenylimino)-3,4- dihydroquinoxalin-2-yl)-3-substituted phenyl-1H-pyrazole-4-carbaldehyde were done by cyclization of dehydrated hemiketal using VilsmeierHaack reaction. The structures of synthesized compounds were in accordance of the basis of IR, 1HNMR, Mass spectral data and elemental analyses. The synthesized compounds had given good yields and high purity. Methods: The antimicrobial activity of the synthesized compounds was preliminarily screened by paper disc diffusion technique. The determination of minimum inhibitory concentrations (MIC) of the synthesized compounds were done by using tube dilution method. Results and Conclusion: All the screened compounds showed antibacterial and antifungal activity against selected strains of Gram positive and Gram negative bacteria and two strains of fungus, respectively but exhibited considerably less activity when compared to the reference drug ciprofloxacin and Fluconazole for antibacterial and antifungal activity, respectively. Among the synthesized compounds VV5 exhibited significant activity.

scholarly journals An efficient, microwave-assisted, one-pot synthesis of novel 5,6,7,8-tetrahydroquinoline-3-carbonitriles

2011 ◽  
Vol 76 (6) ◽  
pp. 823-830 ◽  
Author(s):  
Dipti Dodiya ◽  
Haresh Ram ◽  
Amit Trivedi ◽  
Viresh Shah
Keyword(s):  
1H Nmr ◽  
13C Nmr ◽  
Microwave Assisted Synthesis ◽  
Spectroscopic Techniques ◽  
One Pot ◽  
Antifungal Activities ◽  
Microwave Assisted ◽  
Antibacterial And Antifungal Activities ◽  
Elemental Analyses ◽  
Antibacterial And Antifungal

An efficient, microwave-assisted synthesis of novel 2-alkoxy- 5,6,7,8-tetrahydroquinoline-3-carbonitriles, which have not hitherto been reported, via reactions of cyclohexanone and arylidene malononitriles in the corresponding alcohols in presence of sodium is described. All the newly synthesized compounds were characterized by the IR, 1H-NMR, 13C-NMR and mass spectroscopic techniques and by elemental analyses. The newly synthesized compounds were evaluated for their antibacterial and antifungal activities.

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