scholarly journals Synthesis and Antimicrobial Evaluation of Some Condensed New Triazolopyrimidines

2019 ◽  
pp. 397-404
Author(s):  
Jatin Vora ◽  
Kartik Vyas
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Biginelli Reaction ◽  
Spectroscopic Techniques ◽  
Efficient Synthesis ◽  
Antibacterial And Antifungal Activity ◽  
1H Nuclear Magnetic Resonance ◽  
Elemental Analyses ◽  
Antimicrobial Evaluation ◽  
Antibacterial And Antifungal ◽  
Compound Series

An efficient synthesis of a novel compound series of 2-[3,5-bis(trifluoromethyl)phenyl]-4-(substitutedphenyl)-1,4-dihydropyrimido[1,2-a]benzimidazole (Biginelli reaction) was accomplished from (E)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(4-chlorophenyl)prop-2-en-1-one and 1H-benzo[d]imidazol-2-amine Microwave 25 minute heating after the product obtained another method Conventional 7 hrs, with 30 % KOH, Ethanol. Here (E)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(4-chlorophenyl)prop-2-en-1-one(Chalcone) is prepared by 1-(3,5-bis(trifluoromethyl)phenyl)ethanone and different aldehyde with Claisen-Schimidt Condensation.All the newly synthesized compounds were characterized by infrared and 1H nuclear magnetic resonance and mass spectroscopic techniques and by elemental analyses. The newly synthesized compounds were evaluated for their antibacterial and antifungal activity.

scholarly journals Synthesis and biological Evaluation of Some Abbreviated New Triazolopyrimidines

2019 ◽  
pp. 354-361
Author(s):  
Jatin Vora ◽  
Kartik Vyas
Keyword(s):  
Biginelli Reaction ◽  
Biological Evaluation ◽  
Spectroscopic Techniques ◽  
The Novel ◽  
Antibacterial And Antifungal Activity ◽  
1H Nuclear Magnetic Resonance ◽  
Elemental Analyses ◽  
Antibacterial And Antifungal ◽  
Synthesis And Biological Evaluation ◽  
Compound Series

A cogent synthesis of completely new compound series of by 6-(3,5-bis(trifluoromethyl)phenyl)-4-(4-chlorophenyl)-3,4-dihydro pyrimidine-2(1H)-one (Biginelli reaction) was achieved by continue heating of (E)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(substituted phenyl)prop-2-en-1-one and urea for 5 hours with 40% KOH and ethyl alcohol. (E)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(substituted phenyl)prop-2-en-1-one is produced by Claisen-Schmidt Condensation. In this condensation 1-(3,5-bis(trifluoromethyl)phenyl)ethanone and different aldehyde are mixed. All the novel compound series were characterized by infrared and 1H nuclear magnetic resonance and mass spectroscopic techniques and by elemental analyses. The newly synthesized compounds were evaluated for their antibacterial and antifungal activity

scholarly journals Chemistry and Biological Evaluation of Some New Triazolopyrimidine Derivatives Containing Isopropyl Group

2019 ◽  
pp. 390-396
Author(s):  
Janaki H. Chauhan ◽  
Haresh K. Ram
Keyword(s):  
Antifungal Activity ◽  
1H Nmr ◽  
Biological Evaluation ◽  
Spectroscopic Techniques ◽  
Efficient Synthesis ◽  
Antibacterial And Antifungal Activity ◽  
Isopropyl Group ◽  
Elemental Analyses ◽  
Antibacterial And Antifungal

An efficient Synthesis of a novel series of N,7-bis(substitutedphenyl)-4,7-dihydro-5-isopropyl-[1,2,4]triazolo-[1,5-a]pyrimidine-6-carboxamide (4a-j) was accomplished from N-(substituedphenyl)-4-methyl-3-oxopentanamide, 3-amino-1,2,4-triazole and different aldehyde reflex 20 min with DMF and then after the cooling product was obtained. All the recently synthesized compounds were characterized by the Mass, IR, 1H-NMR and mass spectroscopic techniques and by elemental analyses. The newly synthesized compounds were assessed for their antibacterial and antifungal activity.

Synthesis, Characterization, and Antimicrobial Evaluation of New Furan2-Carboxamide Derivatives

2021 ◽  
Vol 18 ◽  
Author(s):  
Kamal Sweidan ◽  
Gada Idrees ◽  
Luay Abu-Qatouseh ◽  
Muhammad Nawaz Tahir ◽  
Monther Khanfar ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Coli Strain ◽  
Moderate Activity ◽  
Spectroscopic Techniques ◽  
Antibacterial And Antifungal Activity ◽  
X Ray ◽  
E Coli ◽  
Antimicrobial Evaluation ◽  
Antibacterial And Antifungal ◽  
Low Activity

: A new series of furan-2-carboxamide and 5-bromofuran-2-carboxamide derivatives have been prepared in good yields using simple procedures. Our strategy was to synthesize compounds containing functional groups that are known to exhibit significant bioactivity, such as amide (8–15), 2,4-dinitrophenylhydrazone (8a–15a), and thiosemicarbazone (8b– 15b). These newly synthesized compounds have been characterized with the aid of a number of spectroscopic techniques including 1H-NMR, 13C-NMR, IR, and mass spectrometry, in addition two x-ray structures were measured. Antibacterial and antifungal activity of prepared compounds was investigated; antifungal results indicated that compound 8a is the most active whereas compounds 15 and 9b showed moderate activity. Similarly, results of antibacterial testing revealed that most of the prepared compounds exhibit low activity, while compounds containing 2,4-dinitrophenylhydrazone moiety (9a-14a) are the most active towards E. Coli strain.

scholarly journals Simple, novel, and efficient synthesis of ethyl 2-(2-(1H-indol-3-yl)benzo[d]thiazol-3(2H)-yl)-2-cyanoacetate or acetate via a three-component reaction

2020 ◽  
pp. 174751982095201
Author(s):  
Mahmoud Nassiri ◽  
Forough Jalili Milani
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Indole Derivatives ◽  
Efficient Synthesis ◽  
13C Nuclear Magnetic Resonance ◽  
Three Component Reaction ◽  
1H Nuclear Magnetic Resonance ◽  
Elemental Analyses ◽  
New Compounds ◽  
Nuclear Magnetic

Ethyl 2-(2-(1 H-indol-3-yl)benzo[ d]thiazol-3(2 H)-yl)-2-cyanoacetate or acetate 6a–f as a series of novel compounds were synthesized from the reactions of benzothiazole, 2-methylbenzothiazole, or 2,5-dimethylbenzothiazole and ethyl bromocyanoacetate with indole derivatives. The reactions proceeded in acetone as a solvent under reflux for 5 h in good yields. The structures of new compounds were confirmed by 1H nuclear magnetic resonance, 13C nuclear magnetic resonance, infrared, elemental analyses, and mass spectroscopy.

Potential bioactive mononuclear diorganotin(IV) phenoxyacetohydroxamate complexes: synthesis, characterization and antimicrobial evaluation

2018 ◽  
Vol 0 (0) ◽  
Author(s):  
Vineet Kumar Choudhary ◽  
Abhishek Kumar ◽  
Neeraj Sharma
Keyword(s):  
Antimicrobial Agents ◽  
Salmonella Typhi ◽  
Molar Ratio ◽  
Distorted Octahedral Geometry ◽  
Spectroscopic Techniques ◽  
Concentration Method ◽  
Distorted Octahedral ◽  
Elemental Analyses ◽  
Antimicrobial Evaluation

AbstractThe new diorganotin(IV) complexes of composition [Me2Sn(C6H5OCH2CONHO)2](I) and [n-Bu2Sn(C6H5OCH2CONHO)2](II) have been synthesized by the reactions of Me2SnCl2andn-Bu2SnCl2with potassium phenoxyacetohydroxamate (PhOAHK=C6H5OCH2CONHOK) in 1:2 molar ratio in methanol and benzene solvent medium and characterized by elemental analyses and spectroscopic techniques (infrared,1H nuclear magnetic resonance and mass spectrometry). The [O,O coordination] through carbonyl and hydroxamic oxygen atoms and distorted octahedral geometry around the mononuclear tin has been inferred. The electrochemical behavior of complexes studied by the cyclic voltammetric technique has shown quasi-irreversible two-step reduction from tin (IV) to tin (II). Thermal behavior of complexes studied by the thermogravimetric technique in N2atmosphere has yielded SnO as the decomposition product. Thein vitroantimicrobial activity assays against various pathogenic Gram-negative bacteria, namely,Salmonella typhi,Escherichia coli; Gram-positiveBacillus cereusandStaphylococcus aureusand fungiAspergillus nigerandAlternaria alternataby the minimum inhibitory concentration method have shown their potential as promising antimicrobial agents compared to the respective standard chloramphenicol and nystatin drugs.

Synthesis and Antimicrobial Evaluation of Some New 2-(6-Oxo-5,6- dihydro[1,3]thiazolo[3,2-b]-2-aryloxymethyl-1,2,4-triazol-5-yl)-Narylacetamides

2010 ◽  
Vol 65 (5) ◽  
pp. 617-624 ◽  
Author(s):  
Prajwal L. Lobo ◽  
Boja Poojary ◽  
Kumsi Manjunatha ◽  
Nalilu Suchetha Kumari
Keyword(s):  
Acetic Acid ◽  
Antifungal Activity ◽  
Spectral Data ◽  
Good Yield ◽  
Antibacterial And Antifungal Activity ◽  
Acid Media ◽  
Antimicrobial Evaluation ◽  
Antibacterial And Antifungal

A series of 2-(6-oxo-5,6-dihydro[1,3]thiazolo[3,2-b]-2-aryloxymethyl-1,2,4-triazol-5-yl)-Narylacetamides 6 were synthesized in good yield by condensing 5-aryloxymethyl-4H-1,2,4-triazole- 3-thiol 5 with various substituted N-phenyl-maleimides in acetic acid media. The newly synthesized compounds were characterized by spectral data and tested for their in vitro antibacterial and antifungal activity against a variety of microorganisms.

scholarly journals Synthesis of some new 6-aryl-3-(4-isopropylphenyl)[1,2,4]triazolo[3,4-b][1,3,4] thiadiazoles and its anti-microbial study

2021 ◽  
Vol 10 (4) ◽  
pp. 479-488 ◽  
Author(s):  
K. A. Joshi ◽  
J. M. Dhalani ◽  
H. B. Bhatt ◽  
K. M. Kapadiya
Keyword(s):  
Antifungal Activity ◽  
Spectroscopic Techniques ◽  
Aromatic Acids ◽  
Reference Standard ◽  
Antibacterial And Antifungal Activity ◽  
Essential Step ◽  
Step Procedure ◽  
Antibacterial And Antifungal ◽  
Microbial Study

New series of fused 1,2,4-triazoles, i.e., 3-(4-isopropylphenyl)-6-substituted phenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles (5a-5j) have been synthesized via a four-step procedure and using eco-friendly reaction condition at some steps of the synthesis. It was adopted by the formation of hydrazide of methyl 4-isopropylbenzoate (1) followed by reaction with CS2 in basic media to afford potassium salt, which on cyclized to our essential step, 4-amino-5-(4-isopropylphenyl)-4H-1,2,4-triazole-3-thiol (4). The desired adducts (5a-5j) were formed by (4) on reaction with various aromatic acids in POCl3 media. The newly synthesized triazolo- thiadiazoles have been characterized by different spectroscopic techniques and investigated for their in vitro antibacterial and antifungal activity. It was revealed that the compounds 5a, 5c, 5h, and 5i showed interesting antibacterial and antifungal activity compared to the used reference standard.

New polymer syntheses III. Synthesis and characterization of new unsaturated polycarbonates

1994 ◽  
Vol 6 (2) ◽  
pp. 149-154 ◽  
Author(s):  
Kamal I Aly
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Synthesis And Characterization ◽  
Gravimetric Analysis ◽  
Thermal Gravimetric ◽  
X Ray Diffraction ◽  
X Ray ◽  
1H Nuclear Magnetic Resonance ◽  
Elemental Analyses ◽  
Interesting Class

A new interesting class of linear unsaturated polycarbonates based on 3,5-bis(p-hydroxybenzylidene)-isopropylpiperidinone (T), 3,5-divanillylidene isopropylpiperidinone (IT), or 3,5-bis(m-hydroxybenzylidene)-isopropylpiperidinone (III) have been synthesized. An interfacial phosgenation technique carried out at ambient temperature was used for the synthesis of the polycarbonates. The resulting polycarbonates were characterized by elemental analyses, infrared spectroscopy, 1H nuclear magnetic resonance spectral analysis, solubility and viscometry. The thermal behaviour of the synthesized polymers was evaluated by thermal gravimetric analysis and correlated with their structures. The crystallinity of all polymers was examined by x-ray diffraction analysis.

scholarly journals Dacrymenone and VM 3298-2 - New Antibiotics with Antibacterial and Antifungal Activity

2003 ◽  
Vol 58 (7-8) ◽  
pp. 541-546 ◽  
Author(s):  
Viktor Mierau ◽  
Timm Anke ◽  
Olov Sterner
Keyword(s):  
Antifungal Activity ◽  
Spectroscopic Techniques ◽  
Antibacterial And Antifungal Activity ◽  
Enol Ether ◽  
Antifungal Activities ◽  
New Antibiotics ◽  
Methyl Pyruvate ◽  
Antibacterial And Antifungal

Abstract Two new antibiotic metabolites, dacrymenone (1) and VM 3298-2 (2), were isolated from fermentations of a Dacrymyces sp., and their structures were determined by spectroscopic techniques. Dacrymenone (1) is a new eremophilane sesquiterpenoid while VM 3298-2 (2) is a bis-enol ether between methyl pyruvate and 4,6-dihydroxycyclohexan-1,3-dione. Dacrymenone (1) shows weak antibacterial and antifungal activity while VM 3298-2 (2) exhibits cytotoxic and antifungal activities.

scholarly journals Studies on Oligomer Metal Complexes Derived from Bisamic Acid of Pyromellitic Dianhydride and 4-Bromoaniline

2014 ◽  
Vol 2014 ◽  
pp. 1-7
Author(s):  
Yogesh S. Patel
Keyword(s):  
Antifungal Activity ◽  
Metal Complexes ◽  
Terephthalic Acid ◽  
Magnetic Measurement ◽  
Pyromellitic Dianhydride ◽  
Metal Salts ◽  
Spectroscopic Techniques ◽  
Antibacterial And Antifungal Activity ◽  
Transition Metal Salts ◽  
Antibacterial And Antifungal

Novel oligomer metal complexes (2a–f) of the ligand 2,5-bis((4-bromophenyl)carbamoyl) terephthalic acid (1) were prepared using transition metal salts and characterized by various spectroscopic techniques. The geometry of oligomer metal complexes was carried out by electronic spectral analysis and magnetic measurement studies. Polymeric properties have also been carried out. Ligand was synthesized using pyromellitic dianhydride and 4-bromoaniline. It was duly characterized. All novel synthesized compounds 1 and 2a–f were evaluated for their antibacterial and antifungal activity. The results showed significantly higher antibacterial and antifungal activity of oligomer metal complexes compared to the ligand.

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