scholarly journals Toxicity Effects of Intraperitoneal Injection of Biochemical Nanosilver on Cardiac Tissue Structure Following Aerobic Training in Male Wistar Rats

2019 ◽  
Vol 25 (3) ◽  
pp. 172-183
Author(s):  
Forogh Javaheri Houshi ◽  
◽  
Asieh Abbassi-Daloii ◽  
Ahmad Abdi ◽  
Seyed Javad Ziaolhagh ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Wistar Rats ◽  
Cardiac Tissue ◽  
Aerobic Training ◽  
Heart Tissue ◽  
Training Methods ◽  
Male Wistar Rats ◽  
Tissue Changes ◽  
Biological Group ◽  
Toxicity Effects

Aims Silver nanoparticles are among the most valuable products of nanoscale technology, widely used in various sciences. The present study investigated the effects of biochemical silver nanoparticles on the structure of the heart tissue of non-observatory rats in the course of aerobic training. Methods & Materials In this experimental study, 30 male Wistar rats aged 8 to 12 weeks and weighing 34.9±202 g were studied. The rats were randomly divided into 6 groups of control, aerobic training, aerobic training, and nanobiological injection, aerobic and-nanochemical injection, nanobiological injection, and nanochemical injection. Chemical and biological silver was injected intraperitoneally after a period of aerobic training. The specimens were discarded after 48 hours, and the heart tissue was removed. Findings The obtained results revealed the tissue changes, including irregularities and the convergence of chemical nanosilver group significantly increased, compared to the controls. Additionally, in the biological group, there was a slight dispersion of blood in some areas. Following the aerobic training and injection of toxic nanosilver, there was no irregularities, detachment, and hypertension. Only in some areas, sporadically, the accumulation of blood cells was observed in the aerobic training and nanochemical groups. Conclusion More tissue damage occurred in chemical silver nanoparticles, than the biological nanoparticle. Possibly, aerobic training can be highly predictive of these effects.

scholarly journals The potential protective effects of malacca (Phyllanthus emblica L.) extract against doxorubicin-induced cardiotoxicity in male Wistar rats

2021 ◽  
Vol 21 (2) ◽  
pp. 81-88
Author(s):  
ETRINA MELINDA ◽  
ERMI GIRSANG ◽  
ALI NAPIAH NASUTION
Keyword(s):  
Wistar Rats ◽  
Cardiac Tissue ◽  
Heart Tissue ◽  
Phyllanthus Emblica ◽  
Protective Effects ◽  
Chemotherapy Agent ◽  
Sample Extract ◽  
Male Wistar Rats ◽  
The Impact

Doxorubicin as a chemotherapy agent is most widely used in cancer treatment. Long-term use at a predetermined dose has a side effect, namely cardiotoxicity. Doxorubicin-induced cardiotoxicity is considered to be caused by reactive oxygen species (ROS), which is also characterized by increasing CK-MB enzyme levels in the blood. To reduce the impact of doxorubin-induced toxicity, a study was conducted on natural antioxidant sources with cardioprotective capabilities in vivo. Phyllanthus emblica L. fruit was used as a sample for a natural source of antioxidants extracted using ethanol. Then performed a phytochemical screening of secondary metabolites contained in it. This extract was administered orally in various doses to the experimental animal Wistar rats and the induced doxorubicin to these animals. The CK-MB enzyme levels were measured, and the heart organ histopathology test was performed. The results of this study indicate that P. emblica L. fruit extract contains alkaloids, tannins, flavonoids, terpenoids, phenolics, and triterpenoids compounds. Extract treatment at a 400 mg/kg BW dose showed the best reduction in CK-MB levels with great improvements in regular arrangement and shape of myocardial muscle cells of cardiac tissue. The sample extract at a 400 mg/kg BW dose showed remarkably decreasing of CK-MB great improvements of heart tissue on doxorubicin-induced cardiotoxicity. This study showed the potential protective effect of P. emblica L. against doxorubicin-induced cardiotoxicity.

scholarly journals Response of Cardiac Tissue Oxidative Stress After Aerobic Exercise and Capsaicin Administrations in Rats Fed High-Fat Diet

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Maryam Davaran ◽  
Ahmad Abdi ◽  
Javad Mehrabani ◽  
Asieh Abbassi Daloii
Keyword(s):  
Oxidative Stress ◽  
High Fat Diet ◽  
Wistar Rats ◽  
Cardiac Tissue ◽  
Aerobic Training ◽  
Normal Diet ◽  
High Fat ◽  
Male Wistar Rats ◽  
Oxidative Effects ◽  
Antioxidant Effects

Background: Oxidative stress harms cells and impairs the balance between oxidative and antioxidative factors. Exercise and capsaicin have anti-inflammatory and antioxidant effects, as well as some benefits on the cardiovascular system. Objectives: The aim of the present study was to examine the effect of aerobic training with capsaicin on heart changes oxidative stress in rats fed a high-fat diet (HFD). Methods: In this experimental study, 40 male Wistar rats were fed a normal diet (ND, n = 8) or HFD (n = 32) for 8 weeks. After eight weeks, all rats were divided into five groups: ND, HFD, high-fat diet-training (HFDT), high-fat diet-capsaicin (HFDCap), high-fat diet-training-capsaicin (HFDTCap). Training groups performed a progressive aerobic running program (at 15 - 25 m/min, 30 - 60 min/day, and 5 days/week) on a motor-driven treadmill for eight weeks. Capsaicin (4 mg/kg/day) was administered orally, by gavage, once a day. Results: The results showed significant increase in cardiac SOD, GPx and CAT levels in HFDT (P < 0.001), HFDCap (P < 0.001) and HFDTCap (P < 0.001) groups. Also, a significant increase in the amount of this index was observed in the HFDTCap compared to the HFDT and HFDCap groups (P < 0.05). The level of malondialdehyde (MDA) in all experimental groups was significantly lower than the HFD group (P < 0.001). Conclusions: Exercise and capsaicin improve HFD-induced oxidative stress. Therefore, exercise and capsaicin can be used as an appropriate alternative treatment for obesity and its associated inflammatory and oxidative effects.

scholarly journals The Effect of Aerobic Training and Tribulus terrestris Extract on Some Oxidative Stress Indices in the Heart Tissue of Male Wistar Rats Poisoned with Hydrogen Peroxide

2020 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Ali Rasolifoshazeh ◽  
Bahram Abedi ◽  
Hasan Matinhomaee ◽  
Parvin Farzanegi
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Peroxide ◽  
Wistar Rats ◽  
Aerobic Training ◽  
Tissue Concentration ◽  
Heart Tissue ◽  
Tribulus Terrestris ◽  
Stress Indices ◽  
Male Wistar Rats ◽  
Healthy Control

Background: Oxidative stress plays a key role in cardiovascular diseases. Hydrogen peroxide poisoning also increases oxidative stress. In contrast, aerobic exercise and the use of Tribulus terrestris (Tt) extract can individually play an antioxidant defense balance. Objectives: The aim of this study was to investigate the simultaneous effect of aerobic training (AT), and alcoholic extract of Tt on some oxidative stress indices in the heart tissue of hydrogen peroxide poisoned male Wistar rats. Methods: Forty-two male Wistar rats were randomly divided into seven groups, including (1) healthy-control, (2) H2O2, (3) H2O2 + AT, (4) H2O2 + Tt 1 (5 mg/kg), (5) H2O2 + Tt 2 (10 mg/kg), (6) H2O2 + AT + Tt 1, and (7) H2O2 + AT + Tt 2. The AT protocol consisted of eight weeks (5 sessions per week) of treadmill running at 20 m/min for 60 minutes per session. Tissue samples were collected to measure oxidative stress indices. Two-way analysis of variance was used for statistical analysis. Results: A significant decrease in tissue concentration of cytochrome C (ng/mL), MDA (Pmol/mL), PAB index (HK), while an increase in tissue concentration of ATP (µM) was observed in the H2O2 + AT + Tt 2 group compared to other groups (P ≤ 0.05). Conclusions: Combining AT and Tt can be a good strategy to reduce the complications of hydrogen peroxide poisoning. Because the observed changes were far from complete improvement compared to the healthy control group, it is likely that longer treatment periods and higher drug doses should be used. Future studies should use Tribulus terrestris (Tt) supplementation in addition to Tribulus terrestris (Tt) intake prior to training sessions.

scholarly journals African Vegetables (Clerodendrum volibile Leaf and Irvingia gabonensis Seed Extracts) Effectively Mitigate Trastuzumab-Induced Cardiotoxicity in Wistar Rats

2020 ◽  
Vol 2020 ◽  
pp. 1-15
Author(s):  
Olufunke Olorundare ◽  
Adejuwon Adeneye ◽  
Akinyele Akinsola ◽  
Sunday Soyemi ◽  
Alban Mgbehoma ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Wistar Rats ◽  
Cardiac Tissue ◽  
Histopathological Examination ◽  
Radical Scavenging ◽  
Metastatic Breast ◽  
Heart Tissue ◽  
Oxidative Stress Markers ◽  
Her2 Positive ◽  
Stress Markers

Trastuzumab (TZM) is a humanized monoclonal antibody that has been approved for the clinical management of HER2-positive metastatic breast and gastric cancers but its use is limited by its cumulative dose and off-target cardiotoxicity. Unfortunately, till date, there is no approved antidote to this off-target toxicity. Therefore, an acute study was designed at investigating the protective potential and mechanism(s) of CVE and IGE in TZM-induced cardiotoxicity utilizing cardiac enzyme and oxidative stress markers and histopathological endpoints. 400 mg/kg/day CVE and IGE dissolved in 5% DMSO in sterile water were investigated in Wistar rats injected with 2.25 mg/kg/day/i.p. route of TZM for 7 days, using serum cTnI and LDH, complete lipid profile, cardiac tissue oxidative stress markers assays, and histopathological examination of TZM-intoxicated heart tissue. Results showed that 400 mg/kg/day CVE and IGE profoundly attenuated increases in the serum cTnI and LDH levels but caused no significant alterations in the serum lipids and weight gain pattern in the treated rats. CVE and IGE profoundly attenuated alterations in the cardiac tissue oxidative stress markers’ activities while improving TZM-associated cardiac histological lesions. These results suggest that CVE and IGE could be mediating its cardioprotection via antioxidant, free radical scavenging, and antithrombotic mechanisms, thus, highlighting the therapeutic potentials of CVE and IGE in the management of TZM-mediated cardiotoxicity.

Time-dependent biodistribution and excretion of silver nanoparticles in male Wistar rats

2012 ◽  
Vol 32 (11) ◽  
pp. 920-928 ◽  
Author(s):  
K. Dziendzikowska ◽  
J. Gromadzka-Ostrowska ◽  
A. Lankoff ◽  
M. Oczkowski ◽  
A. Krawczyńska ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Wistar Rats ◽  
Time Dependent ◽  
Male Wistar Rats

Effects of Prepubertal Exposure to Silver Nanoparticles on Reproductive Parameters in Adult Male Wistar Rats

2013 ◽  
Vol 76 (17) ◽  
pp. 1023-1032 ◽  
Author(s):  
Hanan Khaled Sleiman ◽  
Renata Marino Romano ◽  
Claudio Alvarenga de Oliveira ◽  
Marco Aurelio Romano
Keyword(s):  
Silver Nanoparticles ◽  
Adult Male ◽  
Wistar Rats ◽  
Reproductive Parameters ◽  
Male Wistar Rats
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