Time-dependent biodistribution and excretion of silver nanoparticles in male Wistar rats

2012 ◽  
Vol 32 (11) ◽  
pp. 920-928 ◽  
Author(s):  
K. Dziendzikowska ◽  
J. Gromadzka-Ostrowska ◽  
A. Lankoff ◽  
M. Oczkowski ◽  
A. Krawczyńska ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Wistar Rats ◽  
Time Dependent ◽  
Male Wistar Rats

Cyclosporine a Dosing-Time-Dependent Effects on Plasma Creatinine and Body Weight in Male Wistar Rats Treated for 3 Weeks

1991 ◽  
Vol 8 (1) ◽  
pp. 25-34 ◽  
Author(s):  
Marie-France Malmary ◽  
Karima Kabbaj ◽  
Christian Labat ◽  
Raymonde Casse ◽  
Jean Oustrin
Keyword(s):  
Body Weight ◽  
Cyclosporine A ◽  
Wistar Rats ◽  
Time Dependent ◽  
Plasma Creatinine ◽  
Male Wistar Rats

Effects of Prepubertal Exposure to Silver Nanoparticles on Reproductive Parameters in Adult Male Wistar Rats

2013 ◽  
Vol 76 (17) ◽  
pp. 1023-1032 ◽  
Author(s):  
Hanan Khaled Sleiman ◽  
Renata Marino Romano ◽  
Claudio Alvarenga de Oliveira ◽  
Marco Aurelio Romano
Keyword(s):  
Silver Nanoparticles ◽  
Adult Male ◽  
Wistar Rats ◽  
Reproductive Parameters ◽  
Male Wistar Rats

Accumulation of Silver Nanoparticles in Brain and Testes during Long-Term Ingestion to Mammals

2017 ◽  
Vol 13 ◽  
pp. 199-205
Author(s):  
Yurii P. Buzulukov ◽  
Ivan V. Gmoshinski ◽  
Anna A. Antsiferova ◽  
Vyacheslav A. Demin ◽  
Vladimir F. Demin ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Consumer Goods ◽  
Wistar Rats ◽  
Pharmaceutical Drugs ◽  
Ag Nps ◽  
Daily Ingestion ◽  
Daily Dose ◽  
Male Wistar Rats ◽  
Living Organisms

Using of silver nanoparticles in consumer goods and in medicine gives big benefits, but there is also the problem of their toxicity for health and environment. There is a lot of literature on experiments with absorption, biodistribution, metabolism and excretion (ADME) of silver nanoparticles in living organisms, but low information exists yet on their accumulation in various biological organs of mammals. Previous experiments have indicated a low clearance of silver nanoparticles from organs, which have histochematic barriers, e.g brain, testes. This article reports the results of three month experiment with daily ingestion of silver nanoparticles to growing male Wistar rats. Experiment was aimed to measure silver mass accumulated in rat's brain and testes under various daily doses. The experiment shows that these organs accumulate silver nanoparticles. Сoncentration of silver nanoparticles in brain and testes after three month of daily ingestion shows dozens times increase compared to single ingestion of daily dose. The experiment demonstrates that accumulation of silver nanoparticles in brain and testes depends on value of daily dose of the nanoparticles. This dependence in brain differs from the same dependence in testes which demonstrate effect of “saturation” or less accumulation with increasing of daily dose. The results of the experiment are of great importance for estimation of toxicity of silver nanoparticles for mammals, developing of regulation documents on using of Ag NPs and for targeted transportation of pharmaceutical drugs.

scholarly journals The Preventive Effects and Mode of Actions of Ulva Fasciata Synthesized Silver Nanoparticles in Doxorubicin-Induced Hepatotoxicity in Wistar Rats

2021 ◽  
pp. 24-48
Author(s):  
Asmaa M. Mahmoud ◽  
Osama M. Ahmed ◽  
Ibraheem B. Mohamed ◽  
Hanan A. Soliman ◽  
Basant M. Mohamed
Keyword(s):  
Oxidative Stress ◽  
Silver Nanoparticles ◽  
Wistar Rats ◽  
Inflammatory Cytokine ◽  
Total Bilirubin Level ◽  
Ethanolic Extract ◽  
Albumin Level ◽  
Concurrent Treatment ◽  
Ulva Fasciata ◽  
Male Wistar Rats

Background: Hepatotoxicity was one of the major side effects associated with doxorubicin treatment in cancer chemotherapy. The synthesized silver nanoparticles (AgNPs) from natural products such as algae especially green algae is one of the favorable means to minimize the deleterious effects of the chemotherapy. Thus, this study aimed to evaluate the preventive role of AgNPs synthesized by Ulva fasciata (U. fasciata) against doxorubicin-induced hepatotoxicity and oxidative stress in the liver of male Wistar rats.  Materials and Methods: In the present study, the green macroalga U. fasciata ethanolic extract was used as reducing agents to reduce Ag ions to Ag0. Doxorubicin-injected male Wistar rats were concomitantly treated with U. fasciata ethanolic extract and AgNPs synthesized by U. fasciata extract (AgNPs/U. fasciata) 3 times/week by oral gavage for 6 weeks. Results: The results showed that male Wistar rats injected with doxorubicin showed a significant increase in ALT, ALP and GGT activities and total bilirubin level as well as a reduction in the serum albumin level. The concurrent treatments of doxorubicin-injected rats with U. fasciata ethanolic extract and AgNPs/U. fasciata significantly abrogate these alterations. The altered levels of tumor biomarkers CA19.9 and AFP as well as pro-inflammatory cytokine, TNF-α, and anti-inflammatory cytokine, IL-4, in doxorubicin-injected animals were significantly ameliorated by concurrent treatment with U. fasciata and AgNPs/U. fasciata. Moreover, the elevated mRNA expression of p53 significantly decreased by treatment. In association, the doxorubicin-induced deleterious histological changes represented by severe hydropic degenerative changes, steatosis, inflammatory cell infiltration, Kupffer cell proliferation and apoptosis were remarkably improved by concurrent treatment with U. fasciata extract and AgNPs/U. fasciata which was more potent. Conclusion: Based on results of this study, it can be concluded that U. fasciata extract and AgNPs/U. fasciata counteracts doxorubicin-induced toxicity by suppression of inflammation, oxidative stress and apoptosis. AgNPs/U. fasciata was the most potent in improving hepatocyte integrity and liver histological architecture.  Graphical Abstract    

Sign in / Sign up

Export Citation Format

Share Document