scholarly journals The Effect of Aerobic Training and Tribulus terrestris Extract on Some Oxidative Stress Indices in the Heart Tissue of Male Wistar Rats Poisoned with Hydrogen Peroxide

2020 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Ali Rasolifoshazeh ◽  
Bahram Abedi ◽  
Hasan Matinhomaee ◽  
Parvin Farzanegi
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Peroxide ◽  
Wistar Rats ◽  
Aerobic Training ◽  
Tissue Concentration ◽  
Heart Tissue ◽  
Tribulus Terrestris ◽  
Stress Indices ◽  
Male Wistar Rats ◽  
Healthy Control

Background: Oxidative stress plays a key role in cardiovascular diseases. Hydrogen peroxide poisoning also increases oxidative stress. In contrast, aerobic exercise and the use of Tribulus terrestris (Tt) extract can individually play an antioxidant defense balance. Objectives: The aim of this study was to investigate the simultaneous effect of aerobic training (AT), and alcoholic extract of Tt on some oxidative stress indices in the heart tissue of hydrogen peroxide poisoned male Wistar rats. Methods: Forty-two male Wistar rats were randomly divided into seven groups, including (1) healthy-control, (2) H2O2, (3) H2O2 + AT, (4) H2O2 + Tt 1 (5 mg/kg), (5) H2O2 + Tt 2 (10 mg/kg), (6) H2O2 + AT + Tt 1, and (7) H2O2 + AT + Tt 2. The AT protocol consisted of eight weeks (5 sessions per week) of treadmill running at 20 m/min for 60 minutes per session. Tissue samples were collected to measure oxidative stress indices. Two-way analysis of variance was used for statistical analysis. Results: A significant decrease in tissue concentration of cytochrome C (ng/mL), MDA (Pmol/mL), PAB index (HK), while an increase in tissue concentration of ATP (µM) was observed in the H2O2 + AT + Tt 2 group compared to other groups (P ≤ 0.05). Conclusions: Combining AT and Tt can be a good strategy to reduce the complications of hydrogen peroxide poisoning. Because the observed changes were far from complete improvement compared to the healthy control group, it is likely that longer treatment periods and higher drug doses should be used. Future studies should use Tribulus terrestris (Tt) supplementation in addition to Tribulus terrestris (Tt) intake prior to training sessions.

Salubrious effects of a vermiculite–cellulose‐based bionanocomposite on oxidative stress indices and histomorphology of male Wistar rats

Andrologia ◽  
2019 ◽  
Vol 52 (1) ◽  
Author(s):  
Chiagoziem A. Otuechere ◽  
Adewale Adewuyi ◽  
Tanitoluwa Oluwabayo ◽  
Folashade Afolayan ◽  
Oghenetega Avwioroko ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Wistar Rats ◽  
Stress Indices ◽  
Male Wistar Rats

scholarly journals Effect of Aerobic Exercise and Hydroalcoholic Extract of Tribulus Terrestris on Mitochondrial Oxidative Stress Markers in Heart Tissue of Rats Poisoned With Hydrogen Peroxide

2021 ◽  
Vol 11 (1) ◽  
pp. 30-43
Author(s):  
Nooshin Delfani ◽  
◽  
Maghsoud Peeri ◽  
Hasan Matin Homaee ◽  
◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Peroxide ◽  
Body Weight ◽  
Aerobic Exercise ◽  
Heart Tissue ◽  
Tribulus Terrestris ◽  
Oxidative Stress Markers ◽  
Mitochondrial Oxidative Stress ◽  
Hydroalcoholic Extract ◽  
Stress Markers

Objective: Oxidative stress can cause DNA damage and apoptosis, and leads to cardiovascular disease. This study aims to evaluate the effect of aerobic exercise combined with consumption of hydroalcoholic extract of tribulus terrestris on mitochondrial oxidative stress markers in heart tissue of rats poisoned with hydrogen peroxide. Methods: This is an experimental study conducted on 42 male Wistar rats divided randomly into seven groups of Control (poisoned without supplementation), Aerobic Exercise, Aerobic Exercise + Supplementation with 5mg/kg extract, Aerobic Exercise + Supplementation with 10 mg/kg extract, Supplementation with 5mg/kg extract, Supplementation with 10mg/kg extract, and healthy control. All groups received hydrogen peroxide (100 mg/kg body weight) for 14 days intraperitoneally. The rats in supplementation groups received hydroalcoholic extract of tribulus terrestris with doses of 5 and 10 mg/kg of body weight by gavage. Aerobic exercise was performed on a treadmill at a speed of 23 m/min for 8 weeks, 5 days per week, each for 30 min. Twenty-four hours after the last exercise session, the heart tissues of rats were collected. Data were analyzed by independent t-test, two-way ANOVA, and Bonferroni post hoc test considering a significance level of P<0.05. Results: Consumption of tribulus terrestris extracts alone and in combination with aerobic exercise led to a significant increase in the levels of O6-methylguanine-DNA-methyl transferase, prooxidants-antioxidant balance, and cytochrome C oxidase, and a significant decrease in adenosine triphosphate and malondialdehyde levels compared to the control group (P<0.05). Conclusion: It seems that regular aerobic exercise and consumption of various doses of tribulus terrestris extract is a moderating factor in mitochondrial biogenesis, and is effective in reducing DNA damage in the heart tissue of rats. Lower dosage of tribulus terrestris extract has more benefits.

scholarly journals Effect of 6 Weeks of Aerobic Training on the Oxidative Stress Condition of Male Wistar Rats Exposed To Particulate Matter

2021 ◽  
Author(s):  
Zahra Eshaghi ◽  
Abdolhamid Habibi ◽  
Seyed Reza Fatemi Tabatabaei ◽  
Gholamreza Goudarzi
Keyword(s):  
Oxidative Stress ◽  
Particulate Matter ◽  
Wistar Rats ◽  
Antioxidant Defense ◽  
Aerobic Training ◽  
Stress Condition ◽  
Infected Group ◽  
Oxidative Stress Condition ◽  
Significant Difference ◽  
Male Wistar Rats

Introduction: Scientific evidence suggests the role of environmental pollutants, especially particulate mater in oxidative stress. However, the regular aerobic training has an important role in enhancing antioxidant defense and resistance to oxidative stress. Therefore, the purpose of this study was to investigate the effect of 6 weeks of aerobic training on the oxidative stress condition of male Wistar rats exposed to particulate matter. Methods: In this experimental study, 32 male rats (245 ± 8.5 g) aged 10 weeks, were divided into 4 groups of 8 rats each. The rats received the infusion of the particulate matter for 6 weeks through the nose. The exercise program included 6 weeks of aerobic training with 50% of maximum exercise; at the end of 6 weeks of the program, 24 hours after the last exercise session, blood samples were taken. Descriptive one-way analysis of variance (ANOVA) was used in different groups. If analysis were significant, differences between groups were estimated using LSD test. Significance was defined as P≤0.05. Statistical analysis was performed using SPSS software version 16. Results: After 6 weeks of aerobic training, levels of Malondialdehyde in both groups: healthy exercise and particulate matter+exercise decreased significantly and in the infected group (P≤0.05), but did not show significant difference compared to the control group (P≥0.05). The level of Superoxide dismutase in the infected group showed a significant increase. There was no significant difference between the two Glutathione peroxidas and catalase enzymes in each group (P≥0.05). Conclusion: Based on the results, it can be concluded that aerobic training may be effective in reducing lipid peroxidation and enhancing antioxidant defense.

scholarly journals Response of Cardiac Tissue Oxidative Stress After Aerobic Exercise and Capsaicin Administrations in Rats Fed High-Fat Diet

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Maryam Davaran ◽  
Ahmad Abdi ◽  
Javad Mehrabani ◽  
Asieh Abbassi Daloii
Keyword(s):  
Oxidative Stress ◽  
High Fat Diet ◽  
Wistar Rats ◽  
Cardiac Tissue ◽  
Aerobic Training ◽  
Normal Diet ◽  
High Fat ◽  
Male Wistar Rats ◽  
Oxidative Effects ◽  
Antioxidant Effects

Background: Oxidative stress harms cells and impairs the balance between oxidative and antioxidative factors. Exercise and capsaicin have anti-inflammatory and antioxidant effects, as well as some benefits on the cardiovascular system. Objectives: The aim of the present study was to examine the effect of aerobic training with capsaicin on heart changes oxidative stress in rats fed a high-fat diet (HFD). Methods: In this experimental study, 40 male Wistar rats were fed a normal diet (ND, n = 8) or HFD (n = 32) for 8 weeks. After eight weeks, all rats were divided into five groups: ND, HFD, high-fat diet-training (HFDT), high-fat diet-capsaicin (HFDCap), high-fat diet-training-capsaicin (HFDTCap). Training groups performed a progressive aerobic running program (at 15 - 25 m/min, 30 - 60 min/day, and 5 days/week) on a motor-driven treadmill for eight weeks. Capsaicin (4 mg/kg/day) was administered orally, by gavage, once a day. Results: The results showed significant increase in cardiac SOD, GPx and CAT levels in HFDT (P < 0.001), HFDCap (P < 0.001) and HFDTCap (P < 0.001) groups. Also, a significant increase in the amount of this index was observed in the HFDTCap compared to the HFDT and HFDCap groups (P < 0.05). The level of malondialdehyde (MDA) in all experimental groups was significantly lower than the HFD group (P < 0.001). Conclusions: Exercise and capsaicin improve HFD-induced oxidative stress. Therefore, exercise and capsaicin can be used as an appropriate alternative treatment for obesity and its associated inflammatory and oxidative effects.

scholarly journals Effect of Iron Enriched Bread Intake on the Oxidative Stress Indices in Male Wistar Rats

2016 ◽  
Vol 18 (9) ◽  
Author(s):  
Sharareh Heidari ◽  
Arash Omidi ◽  
Hamid Reza Gheisari ◽  
Saeed Nazifi
Keyword(s):  
Oxidative Stress ◽  
Wistar Rats ◽  
Stress Indices ◽  
Male Wistar Rats

scholarly journals Toxicity Effects of Intraperitoneal Injection of Biochemical Nanosilver on Cardiac Tissue Structure Following Aerobic Training in Male Wistar Rats

2019 ◽  
Vol 25 (3) ◽  
pp. 172-183
Author(s):  
Forogh Javaheri Houshi ◽  
◽  
Asieh Abbassi-Daloii ◽  
Ahmad Abdi ◽  
Seyed Javad Ziaolhagh ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Wistar Rats ◽  
Cardiac Tissue ◽  
Aerobic Training ◽  
Heart Tissue ◽  
Training Methods ◽  
Male Wistar Rats ◽  
Tissue Changes ◽  
Biological Group ◽  
Toxicity Effects

Aims Silver nanoparticles are among the most valuable products of nanoscale technology, widely used in various sciences. The present study investigated the effects of biochemical silver nanoparticles on the structure of the heart tissue of non-observatory rats in the course of aerobic training. Methods & Materials In this experimental study, 30 male Wistar rats aged 8 to 12 weeks and weighing 34.9±202 g were studied. The rats were randomly divided into 6 groups of control, aerobic training, aerobic training, and nanobiological injection, aerobic and-nanochemical injection, nanobiological injection, and nanochemical injection. Chemical and biological silver was injected intraperitoneally after a period of aerobic training. The specimens were discarded after 48 hours, and the heart tissue was removed. Findings The obtained results revealed the tissue changes, including irregularities and the convergence of chemical nanosilver group significantly increased, compared to the controls. Additionally, in the biological group, there was a slight dispersion of blood in some areas. Following the aerobic training and injection of toxic nanosilver, there was no irregularities, detachment, and hypertension. Only in some areas, sporadically, the accumulation of blood cells was observed in the aerobic training and nanochemical groups. Conclusion More tissue damage occurred in chemical silver nanoparticles, than the biological nanoparticle. Possibly, aerobic training can be highly predictive of these effects.

Aortic-banding induces myocardial oxidative stress and changes in concentration and activity of antioxidants in male Wistar rats

Life Sciences ◽  
2006 ◽  
Vol 79 (23) ◽  
pp. 2187-2193 ◽  
Author(s):  
Maria H.V.M. Jacob ◽  
Mauro R.N. Pontes ◽  
Alex S.R. Araújo ◽  
Jaqueline Barp ◽  
Maria C. Irigoyen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Wistar Rats ◽  
Aortic Banding ◽  
Myocardial Oxidative Stress ◽  
Male Wistar Rats

scholarly journals Effect of concurrent exposure of toxic concentrations of lead and endosulfan on oxidative stress indices in rats

2021 ◽  
Vol 10 (3) ◽  
pp. 192-195
Author(s):  
Ranganathan V ◽  
◽  
Malik JK ◽  
Rao GS ◽  
◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Reduced Glutathione ◽  
Group Iv ◽  
Male Rats ◽  
Technical Grade ◽  
Stress Indices ◽  
Group Iii ◽  
Group I ◽  
Male Wistar Rats ◽  
Toxic Concentrations

The effect of concurrent exposure of toxic concentrations of lead and endosulfan were evaluated on oxidative stress parameters in male wistar rats. Group I served as untreated control whereas Group II received drinking water containing lead as lead acetate @1000 ppm (Pb1000). Group III was exposed to feed containing technical grade endosulfan @ 100 ppm (E100). Group IV was exposed to Pb (1000) +E (100). All the treatments were given daily for 28 days. Combination of lead and endosulfan modified the indices of oxidative stress in the parameters such as lipid peroxidation, reduced glutathione, superoxide dismutase and catalase in rats as compared to their individual compounds. The results suggest that the combination of these individual compounds may have the potential to modify oxidative stress produced by single compounds in male rats

Sign in / Sign up

Export Citation Format

Share Document