Bursicon homodimers induce prophylactic innate immunity in two model insects: Drosophila melanogaster and Aedes aegypti

2016 ◽  
Author(s):  
◽  
Hongwei Zhang
Keyword(s):  
Innate Immunity ◽  
Drosophila Melanogaster ◽  
Aedes Aegypti ◽  
University Of Missouri ◽  
The University

[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.]

Delineating the functional roles of dynamin related proteins in plant innate immunity

2015 ◽  
Author(s):  
◽  
John M. Smith
Keyword(s):  
Innate Immunity ◽  
Immune Responses ◽  
Pseudomonas Syringae ◽  
Potential Role ◽  
Vesicular Trafficking ◽  
Microbial Pathogens ◽  
University Of Missouri ◽  
Functional Roles ◽  
The University ◽  
Related Proteins

[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Vesicular trafficking mediates the movement of cargo molecules from donor to target organelles and is emerging as a critical means by which plants modulate immune responses to microbial pathogens. However, relatively few vesicular trafficking proteins have been implicated as regulatory components of plant immune responses. Here, a candidate-based approach was utilized to identify Arabidopsis thaliana Dynamin-Related Protein 2B (DRP2B), as a novel vesicular trafficking protein functioning in flg22-signaling and innate immunity against Pseudomonas syringae. Loss of DRP2B differently affects three distinct branches of the flg22-signaling network. My analysis was extended to investigate other DRP family members which have also been previously implicated in endocytosis. Interestingly, loss of another DRP family member results in an identical separation of immune signaling responses as described for drp2b mutant plants, providing evidence that these two DRPs may operate within a common flg22-induced signaling pathway. In addition to identifying novel components that affect flg22-induced signaling responses, work in this dissertation sought to understand the potential role(s) of flg22-induced endocytosis of FLS2 in the initiation and attenuation of flg22-induced signaling responses. To this end, I made significant contributions showing that vesicular trafficking of FLS2 is important for the desensitization of cells to flg22 via ligand-induced endocytic degradation of FLS2 and that resensitization of cells to flg22 by secretion of newly-synthesized FLS2 prepares cells for subsequent rounds of flg22-perception. Altogether, work in this dissertation provides some of the first evidence of a link between flg22-induced endocytosis of FLS2 and early flg22-signaling responses.

Genetic and physical interactions of Arabidopsis TOPLESS related 2 with regulators of plant innate immunity

2017 ◽  
Author(s):  
◽  
Christopher M. Garner
Keyword(s):  
Immune Response ◽  
Innate Immunity ◽  
Immune System ◽  
Growth And Development ◽  
Molecular Level ◽  
Plant Growth And Development ◽  
University Of Missouri ◽  
Plant Immune System ◽  
Physical Interactions ◽  
The University

[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Plants are constantly subjected to attack from pathogens. In order to defend themselves, plants have evolved a robust immune system. However, activation of this immune system interferes with plant growth and development. As such, it is very important for plant health to keep the immune system properly repressed when not needed. Using genetics and microscopy we have identified a novel repressor of the plant immune system, TOPLESS RELATED 2 (TPR2). TPR2 appears to repress the immune response after activation, thereby preventing a prolonged immune response. These results help us understand how the plant immune system is regulated at a molecular level.

TEM study of boron additions to cobalt aluminide

1988 ◽  
Vol 46 ◽  
pp. 546-547
Author(s):  
Gerald B. Feldewerth
Keyword(s):  
High Temperature ◽  
Turbine Engines ◽  
Major Drawback ◽  
University Of Missouri ◽  
Specific Strength ◽  
Aerospace Applications ◽  
Wide Range ◽  
Ordered Alloys ◽  
The University ◽  
Very High

In recent years an increasing emphasis has been placed on the study of high temperature intermetallic compounds for possible aerospace applications. One group of interest is the B2 aiuminides. This group of intermetaliics has a very high melting temperature, good high temperature, and excellent specific strength. These qualities make it a candidate for applications such as turbine engines. The B2 aiuminides exist over a wide range of compositions and also have a large solubility for third element substitutional additions, which may allow alloying additions to overcome their major drawback, their brittle nature.One B2 aluminide currently being studied is cobalt aluminide. Optical microscopy of CoAl alloys produced at the University of Missouri-Rolla showed a dramatic decrease in the grain size which affects the yield strength and flow stress of long range ordered alloys, and a change in the grain shape with the addition of 0.5 % boron.

MARS — Its Tenth Anniversary of Operation and its Future

1980 ◽  
Vol 19 (03) ◽  
pp. 125-132
Author(s):  
G. S. Lodwick ◽  
C. R. Wickizer ◽  
E. Dickhaus
Keyword(s):  
Conceptual Development ◽  
Administrative Support ◽  
Final Section ◽  
Economic Benefits ◽  
Hospital Environment ◽  
Computer Scientist ◽  
University Of Missouri ◽  
Complete Bibliography ◽  
The University ◽  
Economic Considerations

The Missouri Automated Radiology System recently passed its tenth year of clinical operation at the University of Missouri. This article presents the views of a radiologist who has been instrumental in the conceptual development and administrative support of MARS for most of this period, an economist who evaluated MARS from 1972 to 1974 as part of her doctoral dissertation, and a computer scientist who has worked for two years in the development of a Standard MUMPS version of MARS. The first section provides a historical perspective. The second deals with economic considerations of the present MARS system, and suggests those improvements which offer the greatest economic benefits. The final section discusses the new approaches employed in the latest version of MARS, as well as areas for further application in the overall radiology and hospital environment. A complete bibliography on MARS is provided for further reading.

scholarly journals Temperature modulates innate immunity in Aedes aegypti during chikungunya virus infection

2020 ◽  
Vol 101 ◽  
pp. 489
Author(s):  
B.R. Wimalasiri-Yapa ◽  
F. Frentiu ◽  
L. Stassen ◽  
R. Gumiel
Keyword(s):  
Innate Immunity ◽  
Virus Infection ◽  
Aedes Aegypti ◽  
Chikungunya Virus

Structure, Expression, and Hormonal Control of Genes from the Mosquito, Aedes aegypti, Which Encode Proteins Similar to the Vitelline Membrane Proteins of Drosophila melanogaster

1993 ◽  
Vol 155 (2) ◽  
pp. 558-568 ◽  
Author(s):  
Yonggu Lin ◽  
Martha T. Hamblin ◽  
Marten J. Edwards ◽  
Carolina Barillas-Mury ◽  
Michael R. Kanost ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Membrane Proteins ◽  
Aedes Aegypti ◽  
Hormonal Control ◽  
Vitelline Membrane

An Interactive Morphological Matrix Computational Design Tool: A Hybrid of Two Methods

2007 ◽  
Author(s):  
Cari R. Bryant ◽  
Matt Bohm ◽  
Robert B. Stone ◽  
Daniel A. McAdams
Keyword(s):  
Computational Design ◽  
Design Tool ◽  
Design Tools ◽  
Concept Generation ◽  
University Of Missouri ◽  
Generation Algorithm ◽  
Design Theories ◽  
The University ◽  
Matrix Generator

This paper builds on previous concept generation techniques explored at the University of Missouri - Rolla and presents an interactive concept generation tool aimed specifically at the early concept generation phase of the design process. Research into automated concept generation design theories led to the creation of two distinct design tools: an automated morphological search that presents a designer with a static matrix of solutions that solve the desired input functionality and a computational concept generation algorithm that presents a designer with a static list of compatible component chains that solve the desired input functionality. The merger of both the automated morphological matrix and concept generation algorithm yields an interactive concept generator that allows the user to select specific solution components while receiving instantaneous feedback on component compatibility. The research presented evaluates the conceptual results from the hybrid morphological matrix approach and compares interactively constructed solutions to those returned by the non-interactive automated morphological matrix generator using a dog food sample packet counter as a case study.

Beyond the border war : student civil rights activism at the University of Kansas and the University of Missouri, 1946-1954

2020 ◽  
Author(s):  
◽  
Mary Beth Brown
Keyword(s):  
World War Ii ◽  
Civil Rights ◽  
Race Relations ◽  
Student Activism ◽  
University Of Kansas ◽  
University Of Missouri ◽  
Effect Change ◽  
Student Activists ◽  
The University ◽  
The 19Th Century

[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI-COLUMBIA AT REQUEST OF AUTHOR.] This dissertation examines post-World War II student civil rights activism at two Midwestern college campuses, the University of Missouri (MU) and the University of Kansas (KU). Missouri and Kansas have conflicting histories concerning race dating back to Bleeding Kansas and the history of race relations on the campuses of KU and MU. This history is especially complicated during the period between 1946 and 1954 because of heightened student activism that challenged racial injustices. Race relations on campus largely mirrored that of the state's political environment, with KU having integrated in the 19th century, whereas MU did not desegregate until 1950. However, the same did not apply to the success of student activists at each school where MU students found success fighting against discriminatory practices in Columbia, whereas local business leaders and the university administration stymied KU students. The dissertation examines the exchange of ideas and strategy among students, which occurred through athletics, debates, guest speakers, and various regional and national groups. In particular, the study argues that campus spaces, such as residential co-ops and student organizations, were deeply significant because they served as incubators of activism by offering students a place to talk about racial and social injustice and plan ways to challenge these inequalities and effect change on campus and in the broader community.

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