scholarly journals Cardiotonic Agent

2020 ◽  
Author(s):  
Keyword(s):  
Cardiotonic Agent

Interaction between amrinone and parathyroid hormone on bone in culture

1982 ◽  
Vol 243 (6) ◽  
pp. E499-E504
Author(s):  
N. S. Krieger ◽  
P. H. Stern
Keyword(s):  
Parathyroid Hormone ◽  
Bone Resorption ◽  
Direct Interaction ◽  
Inhibitory Effects ◽  
Dihydroxyvitamin D3 ◽  
Basal Bone ◽  
Cardiotonic Agent ◽  
Neonatal Mouse Calvaria ◽  
Dose Dependent ◽  
Stimulation Of

The cardiotonic agent amrinone has been postulated to directly affect Na-Ca exchange. Because stimulated bone resorption has been proposed to require Na-Ca exchange, we examined the effects of amrinone on bone. Amrinone inhibited release of Ca from neonatal mouse calvaria in organ culture stimulated by parathyroid hormone (PTH), 1,25-dihydroxyvitamin d3, or prostaglandin E2. Inhibition was dose dependent and maximal at 2 X 10(-4) M. The effect of amrinone differed from the inhibitory effects of calcitonin, ouabain, or nigericin in that 1) 6-h exposure to amrinone alone prevented the effect of subsequently added PTH; 2) amrinone was only partially effective if added after resorption was initiated by 24-h treatment with PTH; 3) coincubation with amrinone and PTH during the first 48 h of culture allowed for a response to PTH after amrinone was removed; no such protection by a stimulator occurred with ouabain or nigericin. Also submaximal concentrations of amrinone plus calcitonin, ouabain, or nigericin gave greater than additive inhibition of Ca release. Amrinone had no effect on basal bone cAMP or on the acute stimulation of cAMP by PTH. The results suggest that amrinone could have a more direct interaction with the pathway involved in stimulated bone resorption than the other inhibitors.

Synthesis of Amrinone, A Cardiotonic Agent

1988 ◽  
Vol 35 (3) ◽  
pp. 233-236 ◽  
Author(s):  
Min-Jen Shiao ◽  
Puh Shieh ◽  
Jen-Shiow Lai
Keyword(s):  
Cardiotonic Agent

Pharmacological Actions of DPN 205–734, a Novel Cardiotonic Agent

1988 ◽  
Vol 12 (4) ◽  
pp. 451-460 ◽  
Author(s):  
R. Salzmann ◽  
G. Scholtysik ◽  
R. Markstein ◽  
G. Bormann
Keyword(s):  
Cardiotonic Agent

Cardiovascular Properties of a New Cardiotonic Agent, MDL 19205

1984 ◽  
Vol 6 (1) ◽  
pp. l43 ◽  
Author(s):  
Richard C. Dage ◽  
Lawrence E. Roebel ◽  
Chih Peng Hsieh ◽  
James K. Woodward
Keyword(s):  
Cardiotonic Agent

USE OF CARDIOTONIC AGENT (MEPHENTERMINE) IN MYOCARDIAL DEPRESSION DUE TO POTASSIUM

1961 ◽  
Vol 5 (2) ◽  
pp. 135???136
Author(s):  
T. COOPER ◽  
V. L. WILLMAN ◽  
P. ZAFIRACOPOLOUS ◽  
C. R. HANLON
Keyword(s):  
Myocardial Depression ◽  
Cardiotonic Agent
Sign in / Sign up

Export Citation Format

Share Document