A new cardiotonic agent, OPC-8212, elevates the myocardial oxygen consumption versus pressure-volume area (PVA) relation in a similar manner to catecholamines and calcium in canine hearts

1988 ◽  
Vol 4 (3) ◽  
pp. 153-161 ◽  
Author(s):  
Shiho Futaki ◽  
Takashi Nozawa ◽  
Yoshio Yasumura ◽  
Nobuaki Tanaka ◽  
Hiroyuki Suga
Keyword(s):  
Oxygen Consumption ◽  
Myocardial Oxygen Consumption ◽  
Cardiotonic Agent

Effect of MDL 17043, a new cardiotonic agent, on myocardial oxygen consumption

1983 ◽  
Vol 35 (4) ◽  
pp. 247-249 ◽  
Author(s):  
Lawrence E. Roebel ◽  
Robert J. Hodgeman ◽  
Nelson L. Velayo ◽  
Richard C. Dage ◽  
James K. Woodward
Keyword(s):  
Oxygen Consumption ◽  
Myocardial Oxygen Consumption ◽  
Cardiotonic Agent

Clinical and Experimental Analysis of 201Thallium Uptake of the Heart

1978 ◽  
Vol 17 (04) ◽  
pp. 142-148
Author(s):  
U. Büll ◽  
S. Bürger ◽  
B. E. Strauer
Keyword(s):  
Oxygen Consumption ◽  
Left Ventricle ◽  
Muscle Mass ◽  
Myocardial Oxygen Consumption ◽  
Animal Experiments ◽  
Left Ventricular ◽  
Left Ventricular Wall ◽  
Ventricular Wall ◽  
Flow Measurements ◽  
Myocardial Flow

Studies were carried out in order to determine the factors influencing myocardial 201T1 uptake. A total of 158 patients was examined with regard to both 201T1 uptake and the assessment of left ventricular and coronary function (e. g. quantitative ventriculography, coronary arteriography, coronary blood flow measurements). Moreover, 42 animal experiments (closed chest cat) were performed. The results demonstrate that:1) 201T1 uptake in the normal and hypertrophied human heart is linearly correlated with the muscle mass of the left ventricle (LVMM);2) 201T1 uptake is enhanced in the inner (subendocardial) layer and is decreased in the outer (subepicardial) layer of the left ventricular wall. The 201T1 uptake of the right ventricle is 40% lower in comparison to the left ventricle;3) the basic correlation between 201T1 uptake and LVMM is influenced by alterations of both myocardial flow and myocardial oxygen consumption; and4) inotropic interventions (isoproterenol, calcium, norepinephrine) as well as coronary dilatation (dipyridamole) may considerably augment 201T1 uptake in accordance with changes in myocardial oxygen consumption and/or myocardial flow.It is concluded that myocardial 201T1 uptake is determined by multiple factors. The major determinants have been shown to include (i) muscle mass, (ii) myocardial flow and (iii) myocardial oxygen consumption. The clinical data obtained from patient groups with normal ventricular function, with coronary artery disease, with left ventricular wall motion abnormalities and with different degree of left ventricular hypertrophy are correlated with quantitated myocardial 201T1 uptake.

Rate-pressure product and myocardial oxygen consumption during surgery for coronary artery bypass.

Circulation ◽  
1979 ◽  
Vol 60 (2) ◽  
pp. 170-173 ◽  
Author(s):  
P L Wilkinson ◽  
J R Moyers ◽  
T Ports ◽  
K Chatterjee ◽  
D Ullyott ◽  
...  
Keyword(s):  
Oxygen Consumption ◽  
Coronary Artery ◽  
Coronary Artery Bypass ◽  
Myocardial Oxygen Consumption ◽  
Artery Bypass ◽  
Rate Pressure Product

ACE Inhibitors Promote Nitric Oxide Accumulation to Modulate Myocardial Oxygen Consumption

Circulation ◽  
1997 ◽  
Vol 95 (1) ◽  
pp. 176-182 ◽  
Author(s):  
Xiaoping Zhang ◽  
Yi-Wu Xie ◽  
Alberto Nasjletti ◽  
Xiaobin Xu ◽  
Michael S. Wolin ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Oxygen Consumption ◽  
Ace Inhibitors ◽  
Myocardial Oxygen Consumption

scholarly journals Development of an automated closed-loop β-blocker delivery system to stably reduce myocardial oxygen consumption without inducing circulatory collapse in a canine heart failure model: a proof of concept study

2021 ◽  
Author(s):  
Takuya Nishikawa ◽  
Kazunori Uemura ◽  
Yohsuke Hayama ◽  
Toru Kawada ◽  
Keita Saku ◽  
...  
Keyword(s):  
Heart Failure ◽  
Oxygen Consumption ◽  
Myocardial Oxygen Consumption ◽  
Atrial Pressure ◽  
Right Atrial ◽  
Canine Heart ◽  
Circulatory Collapse ◽  
Inotropic Effects ◽  
Administration System ◽  
Β Blocker

AbstractBeta-blockers are well known to reduce myocardial oxygen consumption (MVO2) and improve the prognosis of heart failure (HF) patients. However, its negative chronotropic and inotropic effects limit their use in the acute phase of HF due to the risk of circulatory collapse. In this study, as a first step for a safe β-blocker administration strategy, we aimed to develop and evaluate the feasibility of an automated β-blocker administration system. We developed a system to monitor arterial pressure (AP), left atrial pressure (PLA), right atrial pressure, and cardiac output. Using negative feedback of hemodynamics, the system controls AP and PLA by administering landiolol (an ultra-short-acting β-blocker), dextran, and furosemide. We applied the system for 60 min to 6 mongrel dogs with rapid pacing-induced HF. In all dogs, the system automatically adjusted the doses of the drugs. Mean AP and mean PLA were controlled within the acceptable ranges (AP within 5 mmHg below target; PLA within 2 mmHg above target) more than 95% of the time. Median absolute performance error was small for AP [median (interquartile range), 3.1% (2.2–3.8)] and PLA [3.6% (2.2–5.7)]. The system decreased MVO2 and PLA significantly. We demonstrated the feasibility of an automated β-blocker administration system in a canine model of acute HF. The system controlled AP and PLA to avoid circulatory collapse, and reduced MVO2 significantly. As the system can help the management of patients with HF, further validations in larger samples and development for clinical applications are warranted.

Myocardial oxygen consumption of blood-perfused, isolated, supported, rat heart

1970 ◽  
Vol 219 (3) ◽  
pp. 604-612 ◽  
Author(s):  
WJ Gamble ◽  
PA Conn ◽  
AE Kumar ◽  
R Plenge ◽  
RG Monroe
Keyword(s):  
Oxygen Consumption ◽  
Rat Heart ◽  
Myocardial Oxygen Consumption

Effect of heparin-induced elevation of free fatty acids on myocardial oxygen consumption in man

1976 ◽  
Vol 37 (1) ◽  
pp. 167 ◽  
Author(s):  
William J. Rogers ◽  
Richard O. Russell ◽  
Roger E. Moraski ◽  
Huey G. McDaniel ◽  
Charles E. Rackley
Keyword(s):  
Fatty Acids ◽  
Oxygen Consumption ◽  
Free Fatty Acids ◽  
Myocardial Oxygen Consumption
Sign in / Sign up

Export Citation Format

Share Document