Arthus Reaction

2020 ◽  
Author(s):  
Keyword(s):  
Science ◽  
1994 ◽  
Vol 265 (5175) ◽  
pp. 1095-1098 ◽  
Author(s):  
D. Sylvestre ◽  
J. Ravetch

1994 ◽  
Vol 8 (1) ◽  
pp. 84
Author(s):  
T. Tachibana ◽  
S. Taniguchi ◽  
S. Imamura
Keyword(s):  

1984 ◽  
Vol 13 (1) ◽  
pp. 93-108 ◽  
Author(s):  
B.S. Dhodapkar ◽  
J.L. Vegad ◽  
R.G. Dhawedkar ◽  
G.N. Kolte
Keyword(s):  

1975 ◽  
Vol 5 (1) ◽  
pp. 39-47 ◽  
Author(s):  
Marvin B. Goldlust ◽  
William F. Schreiber

Blood ◽  
2008 ◽  
Vol 111 (2) ◽  
pp. 894-904 ◽  
Author(s):  
Rangaiah Shashidharamurthy ◽  
Randolph A. Hennigar ◽  
Sebastien Fuchs ◽  
Purani Palaniswami ◽  
Melanie Sherman ◽  
...  

Extravasation and emigration of neutrophils to the site of inflammation are essential early steps in the initiation of many antibody-mediated autoimmune diseases. The Fc domains of cell bound autoantibodies or immune-complexes (IC) are capable of triggering the neutrophil emigration via complement and FcγRs-mediated mechanisms. To define the clinical relevance and the relative contribution of these 2 pathways in IC-mediated neutrophil emigration, we have neutralized the FcγR-binding activity of IC with a recombinant dimeric Fc receptor, CD16A-Ig, and investigated the early events of IC-induced inflammation in mice. Systemic administration of purified CD16A-Ig blocked IC-induced inflammation, mast- cell degranulation, and extravasation of neutrophils in a reversed Arthus reaction. Although the binding of CD16A-Ig to IC did not alter the complement-activating properties of IC, no evidence for complement-dependent neutrophil emigration was observed. These results suggest that interaction of IC with cells expressing FcγRs at the inflammatory site results in the secretion of chemoattractants, which mediate complement-independent emigration of neutrophils in this cutaneous acute inflammation model. Furthermore, blocking the interaction of IC to FcγRs expressed on inflammatory cells by administering high-avidity Fc fusion dimers of low-affinity FcγRs is an effective way of preventing IC-induced acute inflammation in autoimmune diseases.


Immunity ◽  
1996 ◽  
Vol 5 (2) ◽  
pp. 181-188 ◽  
Author(s):  
Wouter L.W Hazenbos ◽  
J.Engelbert Gessner ◽  
Frans M.A Hofhuis ◽  
Henri Kuipers ◽  
Dirk Meyer ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document