Fc receptors initiate the Arthus reaction: redefining the inflammatory cascade

Science ◽  
1994 ◽  
Vol 265 (5175) ◽  
pp. 1095-1098 ◽  
Author(s):  
D. Sylvestre ◽  
J. Ravetch
Keyword(s):  
Fc Receptors ◽  
Arthus Reaction ◽  
Inflammatory Cascade

scholarly journals A Dominant Role for Mast Cell Fc Receptors in the Arthus Reaction

Immunity ◽  
1996 ◽  
Vol 5 (4) ◽  
pp. 387-390 ◽  
Author(s):  
Diana L Sylvestre ◽  
Jeffrey V Ravetch
Keyword(s):  
Mast Cell ◽  
Dominant Role ◽  
Fc Receptors ◽  
Arthus Reaction

Expression and Function of Fc Receptors in the Thymus

1995 ◽  
Vol 15 (3-4) ◽  
pp. 215-233 ◽  
Author(s):  
Georges Leclercq ◽  
Jean Plum
Keyword(s):  
Fc Receptors ◽  
And Function

scholarly journals Treating COVID-19: are we missing out the window of opportunity?

2020 ◽  
Author(s):  
Jeremiah Sundararaj Stanleyraj ◽  
Nandini Sethuraman ◽  
Rajesh Gupta ◽  
Sohanlal Thiruvoth ◽  
Manisha Gupta ◽  
...  
Keyword(s):  
Viral Replication ◽  
Severe Disease ◽  
Window Of Opportunity ◽  
Time Intervals ◽  
Immunomodulatory Agents ◽  
Course Of Disease ◽  
Inflammatory Cascade ◽  
Replication Phase ◽  
Per Se ◽  
The Right

Abstract Severe COVID-19 is a biphasic illness, with an initial viral replication phase, followed by a cascade of inflammatory events. Progression to severe disease is predominantly a function of the inflammatory cascade, rather than viral replication per se. This understanding can be effectively translated to changing our approach in managing the disease. The natural course of disease offers us separate windows of specific time intervals to administer either antiviral or immunomodulatory therapy. Instituting the right attack at the right time would maximize the benefit of treatment. This concept must also be factored into studies that assess the efficacy of antivirals and immunomodulatory agents against COVID-19.

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