scholarly journals Macromolecular Type 2 Creatine Kinase to Total Creatine Kinase Ratio Measurement

2020 ◽  
Author(s):  
Keyword(s):  
Creatine Kinase ◽  
Ratio Measurement ◽  
Total Creatine

scholarly journals Maturation of Mitochondrial and other Isoenzymes of Creatine Kinase in Skeletal Muscle of Preterm Born Infants

1992 ◽  
Vol 29 (3) ◽  
pp. 302-306 ◽  
Author(s):  
J Smeitink ◽  
W Ruitenbeek ◽  
T v Lith ◽  
R Sengers ◽  
F Trijbels ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Creatine Kinase ◽  
Protein Content ◽  
Human Skeletal Muscle ◽  
Specific Activity ◽  
Prenatal Development ◽  
Quadriceps Muscle ◽  
Mitochondrial Creatine Kinase ◽  
Total Creatine ◽  
Preterm Born

We studied pre- and postnatal changes in total creatine kinase (CK) activity, mitochondrial creatine kinase (Mi-CK) activity and immunochemical reactivity with anti-Mi-CK antibodies in skeletal muscle specimens from 12 infants, 10 of them preterm born, after a pregnancy varying between 28 and 40 weeks. Our results demonstrate that Mi-CK is present in fetal human quadriceps muscle and that the specific activity of Mi-CK increases during prenatal development from week 28 to 40 by a factor about two. Generally, adult levels have not been reached at birth, indicating a further postnatal increase of the activity of the enzyme. The Mi-CK protein content also increases during prenatal development. These results suggest that in human skeletal muscle the expression and accumulation of Mi-CK starts at mid-gestation, later than is known to occur for cytosolic CK.

Cardiac Troponin T in Female Athletes during a Two-Day Mountain Marathon

2003 ◽  
Vol 48 (2) ◽  
pp. 41-42 ◽  
Author(s):  
RE Shave ◽  
E Dawson ◽  
P G Whyte ◽  
K George ◽  
D Ball ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Cardiac Troponin ◽  
Female Athletes ◽  
Troponin T ◽  
Venous Blood ◽  
Cardiac Troponin T ◽  
Cardiac Damage ◽  
Blood Samples ◽  
Total Creatine ◽  
Creatine Kinase Isoenzyme Mb

Background: Equivocal studies exist on the potential of cardiac damage following prolonged endurance exercise. Aims: The aim of the study was to examine humoral markers of cardiac damage in female athletes during a 2-day mountain endurance race. Methods: Venous blood samples were drawn from seven female competitors prior to, and immediately following day-1 and day-2 of the event. The serum was analysed for total creatine kinase (CK), creatine kinase isoenzyme MB (CKMB), and cardiac troponin T (cTnT). Results: Elevations in CK and CKMB were apparent following day-1 of the event (mean ± SD; CK 84.1±54.6 mg/L vs. 387±276.7 mg/L, CKMB 2±1.7 mg/L vs. 5.9±1.7 mg/L) and subsequently rose further following race completion (CK 743±500 mg/L, CKMB 11.9±4.9 mg/L). Elevations in cTnT were noted in three competitors following day-1 cTnT (range 0.013–0.044 mg/L) and remained elevated in two competitors following day-2 (range 0.014–0.017 mg/L). Conclusions: The elevations in cTnT likely represent release from the cytosolic fraction. The mechanism responsible for such release is yet to be elucidated.

Activities of creatine kinase and its isoenzymes in serum in various skeletal muscle disorders.

1988 ◽  
Vol 34 (12) ◽  
pp. 2460-2462 ◽  
Author(s):  
J Arenas ◽  
V Diaz ◽  
G Liras ◽  
E Gutierrez ◽  
I Santos ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Creatine Kinase ◽  
Clinical Features ◽  
Principal Factor ◽  
Isoenzyme Pattern ◽  
Type I ◽  
Isoenzyme Analysis ◽  
Muscle Disorders ◽  
Total Creatine ◽  
Skeletal Muscle Disorders

Abstract We studied possible correlations between anatomopathological and clinical features and the values for total creatine kinase (CK; EC 2.7.3.2) and its isoenzymes, including the proportion of CK-MB, in a population displaying several neuromuscular pathologies. Although we observed no specific isoenzyme pattern associated with the different myopathies, we found isoenzyme analysis useful in studying the histopathological evolution of illness. We also considered whether the pathology was regenerative or nonregenerative, and what type of fiber (I or II) was involved. High CK-MB percentages (greater than 6%) were associated with regenerative and type I fiber myopathies, with regenerative type tissues being the principal factor associated with an increasing proportion of CK-MB. Studying the changes in CK-MB percentage in serum appears to be useful in discriminating neuromuscular from myocardial pathologies.

Sign in / Sign up

Export Citation Format

Share Document