scholarly journals Macromolecular Type 1 Creatine Kinase to Total Creatine Kinase Ratio Measurement

2020 ◽  
Author(s):  
Keyword(s):  
Creatine Kinase ◽  
Ratio Measurement ◽  
Total Creatine

scholarly journals Maturation of Mitochondrial and other Isoenzymes of Creatine Kinase in Skeletal Muscle of Preterm Born Infants

1992 ◽  
Vol 29 (3) ◽  
pp. 302-306 ◽  
Author(s):  
J Smeitink ◽  
W Ruitenbeek ◽  
T v Lith ◽  
R Sengers ◽  
F Trijbels ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Creatine Kinase ◽  
Protein Content ◽  
Human Skeletal Muscle ◽  
Specific Activity ◽  
Prenatal Development ◽  
Quadriceps Muscle ◽  
Mitochondrial Creatine Kinase ◽  
Total Creatine ◽  
Preterm Born

We studied pre- and postnatal changes in total creatine kinase (CK) activity, mitochondrial creatine kinase (Mi-CK) activity and immunochemical reactivity with anti-Mi-CK antibodies in skeletal muscle specimens from 12 infants, 10 of them preterm born, after a pregnancy varying between 28 and 40 weeks. Our results demonstrate that Mi-CK is present in fetal human quadriceps muscle and that the specific activity of Mi-CK increases during prenatal development from week 28 to 40 by a factor about two. Generally, adult levels have not been reached at birth, indicating a further postnatal increase of the activity of the enzyme. The Mi-CK protein content also increases during prenatal development. These results suggest that in human skeletal muscle the expression and accumulation of Mi-CK starts at mid-gestation, later than is known to occur for cytosolic CK.

Cardiac Troponin T in Female Athletes during a Two-Day Mountain Marathon

2003 ◽  
Vol 48 (2) ◽  
pp. 41-42 ◽  
Author(s):  
RE Shave ◽  
E Dawson ◽  
P G Whyte ◽  
K George ◽  
D Ball ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Cardiac Troponin ◽  
Female Athletes ◽  
Troponin T ◽  
Venous Blood ◽  
Cardiac Troponin T ◽  
Cardiac Damage ◽  
Blood Samples ◽  
Total Creatine ◽  
Creatine Kinase Isoenzyme Mb

Background: Equivocal studies exist on the potential of cardiac damage following prolonged endurance exercise. Aims: The aim of the study was to examine humoral markers of cardiac damage in female athletes during a 2-day mountain endurance race. Methods: Venous blood samples were drawn from seven female competitors prior to, and immediately following day-1 and day-2 of the event. The serum was analysed for total creatine kinase (CK), creatine kinase isoenzyme MB (CKMB), and cardiac troponin T (cTnT). Results: Elevations in CK and CKMB were apparent following day-1 of the event (mean ± SD; CK 84.1±54.6 mg/L vs. 387±276.7 mg/L, CKMB 2±1.7 mg/L vs. 5.9±1.7 mg/L) and subsequently rose further following race completion (CK 743±500 mg/L, CKMB 11.9±4.9 mg/L). Elevations in cTnT were noted in three competitors following day-1 cTnT (range 0.013–0.044 mg/L) and remained elevated in two competitors following day-2 (range 0.014–0.017 mg/L). Conclusions: The elevations in cTnT likely represent release from the cytosolic fraction. The mechanism responsible for such release is yet to be elucidated.

Macromolecular creatine kinase type 1: a serum marker associated with disease

1991 ◽  
Vol 37 (3) ◽  
pp. 430-434 ◽  
Author(s):  
Muriȵl Laureys ◽  
Jean-Pau Sion ◽  
Hans Slabbynck ◽  
Laurette Steenssens ◽  
Chrlsta Cobbaert ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Blood Donors ◽  
Serum Marker ◽  
Isoenzyme Analysis ◽  
Life Threatening ◽  
Clinical Associations ◽  
Selection Of Patients ◽  
Age And Sex ◽  
Selection Of

Abstract The prevalence of circulating macromolecular creatine kinase type 1 (macro CK type 1 or CK-immunoglobulin complexes) is significantly higher in a patient population selected for CK isoenzyme assay than in age- and sex-matched blood donors (n = 1304). In greater than 8000 patients studied, 49 individuals with macro CK type 1 were identified, yielding an overall prevalence of 0.61%. Macro CK type 1 complexes occurred more frequently in women and in patients older than 70 years, and were often associated with complications of cardiovascular disease, life-threatening conditions, and poor outcome. These latter clinical associations could arise, at least partly, from the selection of patients for whom CK isoenzyme analysis was ordered.

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