scholarly journals ESR2 Gene

2020 ◽  
Author(s):  
Keyword(s):  
Esr2 Gene

scholarly journals Association Study of rs2987983 Polymorphism in the Promoter Region of ESR2 Gene and Susceptibility to Nodular Thyroid in Women of Markazi Province, Iran

2021 ◽  
Vol 14 (6) ◽  
Author(s):  
Maryam Yousefi ◽  
Ahmad Hamta ◽  
Abdorrahim Sadeghi ◽  
Mehrdad Hashemi ◽  
Afsaneh Talaii ◽  
...  
Keyword(s):  
Thyroid Disease ◽  
Promoter Region ◽  
Thyroid Nodules ◽  
Estrogen Receptor Beta ◽  
Control Group ◽  
Case Group ◽  
Esr2 Gene ◽  
Control Study ◽  
Receptor Beta ◽  
Gene Expression Levels

Background: The risk of thyroid disease has been increased during recent years; more than 200 million people are suffering from various types of thyroid diseases. The rate of thyroid nodules in women is 4 times more than that of men. Epidemiological findings and experimental evidence of thyroid lesions suggest that sex hormones, especially estrogen, may affect this gland and its neoplasms. Objectives: Considering the prevalence of benign and malignant thyroid disease in women, we investigated the association between rs2987983 polymorphism in the estrogen receptor beta gene and nodular thyroid disease. Methods: In this case-control study, 146 patients with thyroid nodules from Amir- Almomenin Hospital in Arak were compared with 151 healthy individuals. The diagnosis was performed by ultrasonography and confirmed by an endocrinologist. After DNA extraction, genotyping was performed with T-ARMS PCR. Finally, statistical analysis was carried out. Results: The frequencies of AA, AG, and GG genotypes in the case group were 48 (32.9%), 83 (56.8%), and 15 (10.3%), respectively. These values in the control group were 64 (42.4%), 64 (42.4%), and 23 (15.2%), respectively. Overall, a statistically significant association (P = 0.042, χ2 = 6.3, df = 2) was observed between rs2987983 polymorphism and thyroid nodules. Conclusions: Considering the significant association between rs2987983 polymorphism and thyroid nodules, it can be suggested that the mentioned polymorphism may be used as a diagnostic biomarker. Because this polymorphism is in the promoter region of the gene, it probably alters gene expression levels.

scholarly journals Common genetic variation in the Estrogen Receptor Beta (ESR2) gene and osteoarthritis: results of a meta-analysis

2010 ◽  
Vol 11 (1) ◽  
Author(s):  
Hanneke JM Kerkhof ◽  
Ingrid Meulenbelt ◽  
Andrew Carr ◽  
Antonio Gonzalez ◽  
Deborah Hart ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Genetic Variation ◽  
Meta Analysis ◽  
Estrogen Receptor Beta ◽  
Common Genetic Variation ◽  
Esr2 Gene ◽  
Receptor Beta

scholarly journals Study of RsaI polymorphism of the ERβ gene in Greek women with endometriosis

2020 ◽  
Vol 19 (3) ◽  
pp. 115-122
Author(s):  
Elli Anagnostou ◽  
Agathi Theodoropoulou ◽  
Despina Mavrogianni ◽  
Athanasios Protopapas ◽  
Peter Drakakis ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Control Group ◽  
Genetic Profile ◽  
Genotype Distribution ◽  
Female Population ◽  
Infertile Women ◽  
Caucasian Origin ◽  
Rsai Polymorphism ◽  
Esr2 Gene

Estrogens and estrogen receptors (ERs) play an important role in the pathogenesis of endometriosis. The aim of this study was to investigate the presence of gene polymorphism RsaI in the gene of the estrogen receptor ERβ in the Greek female population, and its distribution in women suffering from endometriosis and in a control group. We included 67 consecutive infertile women of Caucasian origin who were operated laparoscopically in our Gynecological Endoscopy Unit for endometriosis, and 96 women participated as control group. Patients were genotyped for RsaI (G/A, rs1256049) polymorphism in ESR2 exon 5, using real-time PCR. The patients’ genotype distribution did not differ from the control group. There were no women homozygous for the polymorphic allele in neither group. The different genotypes of ESR2 could not be associated with the stage of endometriosis. The data of this study point that in Greek population who had proven endometriosis the determination of RsaI polymorphism of ESR2 gene doesn’t offer any information for the progression of endometriosis, regarding the genetic profile of this particular gene.

Association of estrogen receptor β (ESR2) gene polymorphism with blood pressure

2000 ◽  
Vol 45 (6) ◽  
pp. 327-330 ◽  
Author(s):  
S. Ogawa ◽  
M. Emi ◽  
M. Shiraki ◽  
T. Hosoi ◽  
Y. Ouchi ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Estrogen Receptor ◽  
Gene Polymorphism ◽  
Estrogen Receptor Β ◽  
Esr2 Gene

scholarly journals Polymorphisms and Haplotypes of the Estrogen Receptor-β Gene (ESR2) and Cardiovascular Disease in Men and Women

2007 ◽  
Vol 53 (10) ◽  
pp. 1749-1756 ◽  
Author(s):  
Kathryn M Rexrode ◽  
Paul M Ridker ◽  
Hillary H Hegener ◽  
Julie E Buring ◽  
JoAnn E Manson ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Estrogen Receptor ◽  
Ischemic Stroke ◽  
White Women ◽  
White Men ◽  
Estrogen Receptor Α ◽  
Estrogen Receptor Β ◽  
Health Study ◽  
Increased Risk ◽  
Esr2 Gene

Abstract Background: Cohort studies suggest an association between variation in the estrogen receptor-α gene (ESR1) and cardiovascular disease (CVD), but data are lacking for the effect of variation in the estrogen receptor-β gene (ESR2). Methods: Three polymorphisms of the ESR2 gene, and their associated haplotypes, were evaluated in 296 white women from the Women’s Health Study and 566 white men from the Physicians’ Health Study who developed CVD [myocardial infarction (MI) or ischemic stroke], each matched 1:1 to a member of the cohort study who remained free from CVD. Blood samples and cardiovascular risk information were collected at baseline. Results: Women, but not men, who developed CVD or MI, but not ischemic stroke, were more likely to have the rs1271572 polymorphism variant T allele (P = 0.05 and 0.02) and less likely to have the rs1256049 polymorphism variant A allele (P = 0.003 and 0.004). No associations were observed for rs4986938. In conditional logistic multivariate regression, the rs1271572 variant was associated with increased odds of CVD [odds ratio (OR) = 1.49, 95% CI: 1.10–2.01] and MI (OR = 1.46, 95% CI: 0.96–2.23), whereas the rs1256049 variant was associated with decreased odds of CVD (OR = 0.37, 95% CI: 0.17–0.79) and MI (OR = 0.25, 95% CI: 0.09–0.73) in women. A common haplotype that included the rs1271572 variant was associated with a 7-fold increased risk of MI in women. Conclusions: Two tightly linked polymorphisms of ESR2 were associated with risk of CVD, particularly MI, in women but not men. Additional studies of ESR2 genetic variation and risk of CVD are warranted.

Polymorphisms in the promoter region of ESR2 gene and susceptibility to ovarian cancer

Gene ◽  
2014 ◽  
Vol 546 (2) ◽  
pp. 283-287 ◽  
Author(s):  
Susanne Schüler ◽  
Claus Lattrich ◽  
Maciej Skrzypczak ◽  
Tanja Fehm ◽  
Olaf Ortmann ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Promoter Region ◽  
Esr2 Gene

Associations of ESR1 and ESR2 gene polymorphisms with metabolic syndrome and its components in postmenopausal women

Maturitas ◽  
2018 ◽  
Vol 115 ◽  
pp. 97-102 ◽  
Author(s):  
Karolina Kuźbicka ◽  
Dominik Rachoń ◽  
Anna Woziwodzka ◽  
Magda Rybicka ◽  
Krzysztof Piotr Bielawski
Keyword(s):  
Metabolic Syndrome ◽  
Postmenopausal Women ◽  
Gene Polymorphisms ◽  
Esr2 Gene

scholarly journals Functional Characterization of a Genetic Polymorphism in the Promoter of the ESR2 Gene

2011 ◽  
Vol 3 (1-2) ◽  
pp. 37-43 ◽  
Author(s):  
Santosh Philips ◽  
Alexandra Richter ◽  
Steffi Oesterreich ◽  
James M. Rae ◽  
David A. Flockhart ◽  
...  
Keyword(s):  
Genetic Polymorphism ◽  
Functional Characterization ◽  
Esr2 Gene

ESR2 Gene and Medullary Thyroid Carcinoma

Thyroid ◽  
2017 ◽  
Vol 27 (11) ◽  
pp. 1456-1457 ◽  
Author(s):  
Macarena Ruiz-Ferrer ◽  
Raquel M. Fernández ◽  
Elena Navarro ◽  
Guillermo Antiñolo ◽  
Salud Borrego
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Medullary Thyroid ◽  
Esr2 Gene
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