scholarly journals Chemical Carcinogen

2020 ◽  
Author(s):  
Keyword(s):  
Chemical Carcinogen

Ultrastructural Changes in the Mammary Epithelial Cell Population During Neoplastic Development Induced by A Chemical Carcinogen.

1976 ◽  
Vol 34 ◽  
pp. 250-251 ◽  
Author(s):  
J. Russo ◽  
W. Isenberg ◽  
M. Ireland ◽  
I.H. Russo
Keyword(s):  
Mammary Gland ◽  
Cell Population ◽  
Virgin Female ◽  
Histological Change ◽  
Mammary Epithelial ◽  
Female Rats ◽  
Ultrastructural Changes ◽  
Post Inoculation ◽  
Chemical Carcinogen ◽  
Sprague Dawley

The induction of rat mammary carcinoma by the chemical carcinogen DMBA is used as a model for the study of the human disease (1). We previously described the histochemical changes that occur in the mammary gland of DMBA treated animals before the earliest manifested histological change, the intraductal proliferation (IDP), was observed (2). In the present work, we demonstrate that a change in the stable cell population found in the resting mammary gland occurs after carcinogen administration.Fifty-five day old Sprague-Dawley virgin female rats were inoculated intragastrically with 20mg of 7,12-dimethylbenz(a)anthracene (DMBA) in 1ml sesame oil. Non-inoculated, age-matched females were used as controls. Mammary glands from control and inoculated rats were removed weekly from the time of inoculation until 60 days post-inoculation. For electron microscopy, the glands were immersed in Karnovsky's fixative, post-fixed in 1% OsO4, dehydrated, and embedded in an Epon-Araldite mixture. Thick (lμ) sections were stained with 1% toluidine blue and were used for selecting areas for ultrastructural study.

Chemical carcinogen alteration of SV40 virus induced transformation of normal human cell populations in vitro

1978 ◽  
Vol 22 (2-3) ◽  
pp. 185-197 ◽  
Author(s):  
George E. Milo ◽  
James R. Blakeslee ◽  
Ronald Hart ◽  
David S. Yohn
Keyword(s):  
Human Cell ◽  
Cell Populations ◽  
Chemical Carcinogen ◽  
Sv40 Virus ◽  
Normal Human Cell ◽  
Normal Human

High incidence of ultraviolet-B-or chemical-carcinogen-induced skin tumours in mice lacking the xeroderma pigmentosum group A gene

Nature ◽  
1995 ◽  
Vol 377 (6545) ◽  
pp. 165-168 ◽  
Author(s):  
Hironobu Nakane ◽  
Seiji Takeuchi ◽  
Shunsuke Yuba ◽  
Masafumi Saijo ◽  
Yoshimichi Nakatsu ◽  
...  
Keyword(s):  
Xeroderma Pigmentosum ◽  
Ultraviolet B ◽  
Chemical Carcinogen ◽  
Skin Tumours ◽  
High Incidence ◽  
Group A ◽  
Xeroderma Pigmentosum Group A
Sign in / Sign up

Export Citation Format

Share Document