scholarly journals Cervicovaginal Secretion

2020 ◽  
Author(s):  
Keyword(s):  
Cervicovaginal Secretion

scholarly journals Differential Diffusions of Indinavir and Lopinavir in Genital Secretions of Human Immunodeficiency Virus-Infected Women

2004 ◽  
Vol 48 (2) ◽  
pp. 632-634 ◽  
Author(s):  
Odile Launay ◽  
Michel Tod ◽  
Kamel Louchahi ◽  
Linda Belarbi ◽  
Olivier Bouchaud ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Genital Tract ◽  
Viral Evolution ◽  
Female Genital Tract ◽  
Immunodeficiency Virus ◽  
The Relationship ◽  
Cervicovaginal Secretion ◽  
Over Time ◽  
Female Genital

ABSTRACT Plasma and cervicovaginal secretion (CVS) samples were collected from 19 human immunodeficiency virus type 1-infected women on lopinavir- or indinavir-containing regimens. Lopinavir and indinavir were detectable in 29 and 93% of CVS samples, respectively, a finding that may be ascribed to these drugs' differences in protein binding and pKa. The relationship between lopinavir and indinavir pharmacodynamics and viral evolution in the female genital tract should be assessed over time.

scholarly journals Study of Prolactin in Cervicovaginal Secretion in Women with Preterm Labor and Normal Pregnancy

2020 ◽  
Vol 12 (1) ◽  
pp. 34-37
Author(s):  
Urmila Singh ◽  
Vandana Solanki ◽  
Seema Mehrotra ◽  
SM Natu ◽  
Shilpi Chauhan ◽  
...  
Keyword(s):  
Preterm Labor ◽  
Normal Pregnancy ◽  
Cervicovaginal Secretion

scholarly journals The role of insulin-like growth factor in prediction and prevention of preterm delivery

2010 ◽  
Vol 67 (11) ◽  
pp. 883-886 ◽  
Author(s):  
Mirjana Bogavac ◽  
Natasa Simin ◽  
Milan Ranisavljevic ◽  
Ljiljana Budisic
Keyword(s):  
Growth Factor ◽  
Pregnant Women ◽  
Preterm Delivery ◽  
Medical Practice ◽  
Fetal Membranes ◽  
Control Group ◽  
Study Group ◽  
Insulin Like Growth Factor ◽  
Prediction And Prevention ◽  
Cervicovaginal Secretion

Background/Aim. Prediction and prevention of preterm delivery remain great challenge. It is important to include in everyday medical practice determination of certain markers that could help identifying pregnant women with preterm delivery. Insulin like growth factor (IGF) is involved in the control mechanism of fetal and placental growth and development. The aim of this study was to examine the presence of insulin-like growth factor binding protein 1 (IGFBP-1) in cervicovaginal secretion of pregnant women with symptoms of preterm labor, but with apparently intact fetal membranes and to point out a possible application of the strip test for detection of phIGFBP-1 in diagnosis of preterm premature rupture of total membranes (PPROM) in everyday medical practice. Methods. The study was performed at the Department for Obstetrics and Gynecology, Clinical Center of Vojvodina between October 2008 and May 2009. The study included 54 pregnant women between 20-35 weeks of gestation (WG), divided into two groups: the study group (16 pregnant women with symptoms of preterm delivery that gave birth before 37 WG) and the control group (38 pregnant women with the normal course of pregnancy that gave birth on term). In cervicovaginal secretion of the examined pregnant women the level of IGFBP-1 was determined by the immunochromatographic assay with monoclonal antibodies 6303 as a detecting antibody (Actim PROM test, Medix Biochemica, Kauniainen, Finland). Results. Gestational age (GA) at delivery in the study group was 32.6 WG and in the control group it was 38.4 WG. Weight of newborns in the study group was 2,021 g and in the control group 3,430 g. IGFBP test was positive in 15 women (93.75%) of the study group, while in the control group it was positive only in 1 woman (2.63%). Conclusion. Test on phIGFBP-1 in cervicovaginal mucus was positive in 93.75% women with preterm delivery, suggesting that this test could be used in diagnosis of silent rupture of fetal membranes and in prediction of preterm delivery.

Secretory leukocyte protease inhibitor levels in cervicovaginal secretion of elderly women

Maturitas ◽  
2006 ◽  
Vol 54 (2) ◽  
pp. 141-148 ◽  
Author(s):  
Koichiro Shimoya ◽  
Qing Zhang ◽  
Kumiko Temma ◽  
Tadashi Kimura ◽  
Tomoko Tsujie ◽  
...  
Keyword(s):  
Protease Inhibitor ◽  
Elderly Women ◽  
Secretory Leukocyte Protease Inhibitor ◽  
Cervicovaginal Secretion

Value of cervicovaginal fluid cytokines in prediction of fetal inflammatory response syndrome in pregnancies complicated with preterm premature rupture of membranes (pPROM)

2020 ◽  
Vol 48 (3) ◽  
pp. 249-255 ◽  
Author(s):  
Mateusz Mikołajczyk ◽  
Przemysław Wirstlein ◽  
Magdalena Adamczyk ◽  
Jana Skrzypczak ◽  
Ewa Wender-Ożegowska
Keyword(s):  
Inflammatory Response ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Preterm Premature Rupture ◽  
Tnf Α ◽  
Cervicovaginal Secretion ◽  
Cervicovaginal Fluid ◽  
Fetal Inflammatory Response

AbstractBackgroundPreterm premature rupture of membranes (pPROM) is associated with a high risk of prematurity and complications of fetal inflammatory response syndrome (FIRS). The aim of the study is to determine any correlations between the concentration of selected cytokines contained in the cervicovaginal secretion eluates and in the umbilical cord plasma in patients with pPROM and to find the noninvasive markers of FIRS in order to pinpoint the optimal time of the delivery.MethodsThe study included 80 patients with pPROM between the 24th and 34th week of gestation. The cervicovaginal fluid and umbilical cord blood were collected. Interleukin 6 (IL-6), interleukin 10 (IL-10), interleukin 19 (IL-19) and tumor necrosis factor-α (TNF-α) concentrations were measured in both materials. For the statistical analysis, SigmaStat3.5 software was used.ResultsThere was no direct association in levels of IL-6, TNF-α, IL-10 and IL-19 between the cord blood and cervicovaginal secretions within the studied group. The cut-off point of IL-6 of 26.8 pg/mL in the vaginal fluid had high sensitivity and specificity in order to discriminate between newborns with and without FIRS (81.08%; 76.74%).ConclusionFurther studies are needed on a larger group of participants to demonstrate that an elevated concentration of IL-6 above 26.8 pg/mL in the cervicovaginal secretion eluate is an indirect noninvasive marker of FIRS.

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