Secretory leukocyte protease inhibitor levels in cervicovaginal secretion of elderly women

Maturitas ◽  
2006 ◽  
Vol 54 (2) ◽  
pp. 141-148 ◽  
Author(s):  
Koichiro Shimoya ◽  
Qing Zhang ◽  
Kumiko Temma ◽  
Tadashi Kimura ◽  
Tomoko Tsujie ◽  
...  
Keyword(s):  
Protease Inhibitor ◽  
Elderly Women ◽  
Secretory Leukocyte Protease Inhibitor ◽  
Cervicovaginal Secretion

scholarly journals SLPI is a critical mediator that controls PTH-induced bone formation

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Akito Morimoto ◽  
Junichi Kikuta ◽  
Keizo Nishikawa ◽  
Takao Sudo ◽  
Maki Uenaka ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Bone Resorption ◽  
Bone Formation ◽  
Protease Inhibitor ◽  
Bone Metabolism ◽  
Serine Protease ◽  
Serine Protease Inhibitor ◽  
Secretory Leukocyte Protease Inhibitor ◽  
Bone Imaging ◽  
Genetic Ablation

AbstractOsteoclastic bone resorption and osteoblastic bone formation/replenishment are closely coupled in bone metabolism. Anabolic parathyroid hormone (PTH), which is commonly used for treating osteoporosis, shifts the balance from osteoclastic to osteoblastic, although it is unclear how these cells are coordinately regulated by PTH. Here, we identify a serine protease inhibitor, secretory leukocyte protease inhibitor (SLPI), as a critical mediator that is involved in the PTH-mediated shift to the osteoblastic phase. Slpi is highly upregulated in osteoblasts by PTH, while genetic ablation of Slpi severely impairs PTH-induced bone formation. Slpi induction in osteoblasts enhances its differentiation, and increases osteoblast–osteoclast contact, thereby suppressing osteoclastic function. Intravital bone imaging reveals that the PTH-mediated association between osteoblasts and osteoclasts is disrupted in the absence of SLPI. Collectively, these results demonstrate that SLPI regulates the communication between osteoblasts and osteoclasts to promote PTH-induced bone anabolism.

scholarly journals Secretory Leukocyte Protease Inhibitor Antagonizes Paclitaxel in Ovarian Cancer Cells

2010 ◽  
Vol 16 (2) ◽  
pp. 600-609 ◽  
Author(s):  
Nabila Rasool ◽  
William LaRochelle ◽  
Haihong Zhong ◽  
Gulshan Ara ◽  
Joshua Cohen ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Protease Inhibitor ◽  
Cancer Cells ◽  
Secretory Leukocyte Protease Inhibitor ◽  
Ovarian Cancer Cells

scholarly journals Quantification of secretory leukocyte protease inhibitor (SLPI) in oral gargle specimens collected using mouthwash

2013 ◽  
Vol 400-401 ◽  
pp. 117-121 ◽  
Author(s):  
Christine M. Pierce Campbell ◽  
Wei Guan ◽  
Robert Sprung ◽  
John M. Koomen ◽  
Michael T. O'Keefe ◽  
...  
Keyword(s):  
Protease Inhibitor ◽  
Secretory Leukocyte Protease Inhibitor

scholarly journals Identification of the secretory leukocyte protease inhibitor (SLPI) as a target of IRF-1 regulation

Oncogene ◽  
1999 ◽  
Vol 18 (39) ◽  
pp. 5455-5463 ◽  
Author(s):  
Hannah Nguyen ◽  
Lindsay Teskey ◽  
Rongtuan Lin ◽  
John Hiscott
Keyword(s):  
Protease Inhibitor ◽  
Secretory Leukocyte Protease Inhibitor
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