scholarly journals Eye Drops, Prolonged Release Dosage Form

2020 ◽  
Author(s):  
Keyword(s):  
Dosage Form ◽  
Prolonged Release ◽  
Eye Drops

scholarly journals Contact Lenses as Ophthalmic Drug Delivery Systems: A Review

Polymers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1102
Author(s):  
Paola Franco ◽  
Iolanda De Marco
Keyword(s):  
Contact Lenses ◽  
Pharmacological Action ◽  
Active Principle ◽  
Prolonged Release ◽  
Eye Drops ◽  
Polymeric Support ◽  
Physiological Factors ◽  
Ophthalmic Drugs ◽  
Innovative Methods ◽  
Ophthalmic Drug

Ophthalmic drugs used for the treatment of various ocular diseases are commonly administered by eye drops. However, due to anatomical and physiological factors, there is a low bioavailability of the active principle. In order to increase the drug residence time on the cornea to adequate levels, therapeutic contact lenses have recently been proposed. The polymeric support that constitutes the contact lens is loaded with the drug; in this way, there is a direct and effective pharmacological action on the target organ, promoting a prolonged release of the active principle. The incorporation of ophthalmic drugs into contact lenses can be performed by different techniques; nowadays, the soaking method is mainly employed. To improve the therapeutic performance of drug-loaded contact lenses, innovative methods have recently been proposed, including the impregnation with supercritical carbon dioxide. This updated review of therapeutic contact lenses production and application provides useful information on the most effective preparation methodologies, recent achievements and future perspectives.

scholarly journals Clinical Application and Efficacy of Silver Drug in Ophthalmology: A Literature Review and New Formulation of EYE Drops with Drug Silver (I) Complex of Metronidazole with Improved Dosage Form

Biomedicines ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 210
Author(s):  
Arleta Waszczykowska ◽  
Dominik Żyro ◽  
Justyn Ochocki ◽  
Piotr Jurowski
Keyword(s):  
Dosage Form ◽  
Complex Analysis ◽  
Bacterial Resistance ◽  
Eye Drops ◽  
Ophthalmic Diseases ◽  
The Stability ◽  
New Formulation ◽  
Additional Therapy ◽  
Antibacterial Potential

The use of silver preparations in medicine is becoming increasingly popular. The basic aim of this evaluation was to review the literature on the clinical (in vivo) and antibacterial potential of silver preparations in ophthalmic diseases. The second goal was to summarize the results of experimental research on the use of silver preparations in ophthalmology. The third objective was to present a method for stabilizing eye drops containing silver (I) complex. Analysis of the pH stability of the silver (I) complex with metronidazole in the prepared dosage form (eye drops) was carried out. Most silver preparations are clinically used for topical application. Few experimental results indicate the usefulness of intraocular or systemic administration of silver (I) preparations as an alternative or additional therapy in infectious and angiogenic eye diseases. The development of a new formulation increases the stability of the dosage form. New forms of silver (I) products will certainly find application in the treatment of many ophthalmic diseases. One of the most important features of the silver (I) complex is its capacity to break down bacterial resistance. The new eye drops formula can significantly improve comfort of use. Due to their chemical nature, silver (I) compounds are difficult to stabilize, especially in the finished dosage form.

Benzyldimethyl[3-(miristoylamino)-propyl]ammonium chloride stabilized silver nanoparticles (Argumistin™) in medicine: results of clinical trials for treatment of infectious diseases of dogs and perspectives for humans

2016 ◽  
Vol 8 (4) ◽  
Author(s):  
Yurii Krutyakov ◽  
Alexey Klimov ◽  
Boris Violin ◽  
Vladimir Kuzmin ◽  
Victoria Ryzhikh ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Clinical Trials ◽  
Infectious Diseases ◽  
Ammonium Chloride ◽  
Dosage Form ◽  
Multiple Drug Resistance ◽  
Periodontal Diseases ◽  
Veterinary Drug ◽  
Antibacterial Drug ◽  
Eye Drops

AbstractIncreased interest in nanosilver during the last 10 years is mainly explained by the emergence and spread of pathogenic microorganisms with multiple drug resistance, including resistance to last-generation antibiotics. In this article, we for the first time, give a description of large-scale clinical trials of a new nanosilver based antibacterial drug [containing two active components: silver nanoparticles (AgNPs) (10–50 ppm) and benzyldimethyl[3-(miristoylamino)-propyl]ammonium chloride (100 ppm)] registered in Russia in 2015 as a veterinary drug under the brand name Argumistin™. This drug has been approved for application in a diluted dosage form – as eye drops, intranasal drops and orally; it has also been approved for application in a more concentrated dosage form (up to 50 ppm of nanosilver) as ear drops and as an antiseptic during demodicosis and gum disease treatment, open wound treatment, etc. We have registered the high therapeutic effectiveness of Argumistin™ during treatment of infectious conjunctivitis, gingivitis, parodontosis and enteritis of dogs. Application of this antibacterial drug gives considerable (up to 70% in case of periodontal diseases) reduction in the treatment period and prevention of complications. The results of clinical trials in the treatment of infectious diseases of dogs makes Argumistin™ a promising candidate for an effective antibacterial drug for human medicine.

scholarly journals Elaboration of the bischofite eye drops using the biopharmaceutical criteria

2011 ◽  
Vol 10 (5) ◽  
pp. 162-166
Author(s):  
B. B. Sysuev ◽  
Ye. B. Sysuev ◽  
I. Yu. Mitrofanova
Keyword(s):  
Analytic Hierarchy Process ◽  
Magnesium Chloride ◽  
Dosage Form ◽  
Practical Importance ◽  
Eye Drops ◽  
Mineral Component ◽  
Analytic Hierarchy ◽  
Pharmaceutical Form ◽  
Hierarchy Process

Our research is of theoretical and practical importance and aims at the development of ophthalmological dosage form comprising mineral component (bischofite). It is mineral complex consisting of 96% magnesium chloride with macro- and microelements. Having carried out complex physicochemical and biopharmaceutical researches in vitro, we developed composition and technology of 10% bischofite solution in the form of eye drops. After is one of the perspective tools in technological researches. After using of the analytic hierarchy process by T. Saaty the optimal eye drops composition was selected according to all chosen criteria for this pharmaceutical form.

Antibacterial Effectiveness of Chloramphenicol Ophthalmic Hydrogel Against Staphylococcus aureus ATCC 25923 and Bacillus subtilis ATCC 6633

2018 ◽  
Vol 9 (3) ◽  
Author(s):  
Kurniawansyah I S ◽  
Sulistiyaningsih . ◽  
Maulia M G ◽  
Budiman A
Keyword(s):  
Antibacterial Activity ◽  
Dosage Form ◽  
Large Fraction ◽  
Three Dimensional ◽  
Polymeric Materials ◽  
Good Alternative ◽  
Eye Drops ◽  
Significant Difference ◽  
Bacillus Subtilis Atcc ◽  
Physical Preparation

Background: Hydrogels are the unique three-dimensional polymeric materials that can hold a large fraction of water thus aims to release the drug in a controlled manner. Controlled drug delivery systems that are meant to deliver the drugs at predetermined rate for a pre-programmed period is a good alternative to accomplish and overcome the inadequacy of low bioavailability of conventional dosage form. Aims and Objectives: To determine the effectiveness of antibacterial activity of chloramphenicol in ophthalmic hydrogel preparations against S. aureus and B. subtilis comparing with eye drops dosage form. Materials and Methods: Ophthalmic hydrogel and eye drops of chloramphenicol were used for comparing the effectiveness of antibacterial activity against S. aureus and B. subtillis using agar diffusion methods with perforation technique. The observations were made for 28 days with evaluation of the physical preparation includes organoleptic, pH, viscosity. Result: The chloramphenicol eye drops preparation showed that the largest inhibition diameter at concentrations 20%,10% and 5% were 2.87-2.90; 2.64-2.76 and 2.48-2.55 cm. During comparison with opthalmic hyrdogel preparations there was not a very significant difference observed at opthalmic hydrogel preparation of 20% , 10% and 5% inhibition diameter obtained were 2.85-2.98; 2.58-2.69 and 2.42-2.46 cm. This showed that both preparations were equally effective in inhibition of S. aureus and B. subtilis growth. The minimum inhibitory concentration growth of the hydrogel opthalmic preparations against the bacteria B. subtilis was 10% and S. aureus at concentration 20%. In the evaluation of the physical preparation includes organoleptic, pH, viscosity showed good results, and still within the range of requirements. Conclusion: The effectiveness of antibacterial preparations in chloramphenicol ophthalmic hydrogel were not much of a difference compared to the form of eye drops preparations against S. aureus and B. subtilis.

Influence of Microencapsulation Process Parameters on Naltrexone Prolonged-Release Dosage Form

2014 ◽  
Vol 48 (1) ◽  
pp. 65-68 ◽  
Author(s):  
E. A. Petrova ◽  
S. A. Kedik ◽  
K. V. Alekseev ◽  
E. V. Blynskaya ◽  
A. V. Panov ◽  
...  
Keyword(s):  
Process Parameters ◽  
Dosage Form ◽  
Prolonged Release
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