scholarly journals Prolonged-Release Capsule, Hard Dosage Form

2020 ◽  
Author(s):  
Keyword(s):  
Dosage Form ◽  
Prolonged Release

Influence of Microencapsulation Process Parameters on Naltrexone Prolonged-Release Dosage Form

2014 ◽  
Vol 48 (1) ◽  
pp. 65-68 ◽  
Author(s):  
E. A. Petrova ◽  
S. A. Kedik ◽  
K. V. Alekseev ◽  
E. V. Blynskaya ◽  
A. V. Panov ◽  
...  
Keyword(s):  
Process Parameters ◽  
Dosage Form ◽  
Prolonged Release

scholarly journals Development of Mebeverine HCl Prolonged release Mini-tablets by thermoplastic granulation technique

2020 ◽  
pp. 260-266
Author(s):  
KETAN B. RAMANI ◽  
Vipul Patel
Keyword(s):  
Dosage Form ◽  
Reference Product ◽  
Aqueous Media ◽  
Manufacturing Cost ◽  
Prolonged Release ◽  
Pore Former ◽  
Hydrogenated Castor Oil ◽  
Ph Range ◽  
Full Factorial ◽  
Melt Granulation

Mebeverine HCl is a BCS class-I drug and thus it possesses high solubility in aqueous media across the biological pH range. The marketed reference product is a multi-unit particulate system (MUPS) containing prolonged release pellets filled in hard gelatin capsule. In conventional manufacturing process, a huge quantity of solvents (aqueous and/or organic) is used to manufacture such dosage form. Additionally, it demands more processing time and efforts. Therefore, a prolonged release capsules dosage form of Mebeverine HCl was formulated using thermoplastic (melt) granulation technique without usage of any solvent. Prolonged release minitablets sized 2 mm in diameter were developed as per quality by design principles. A 23 full-factorial design of experiment was applied to optimize levels of drug release controlling ingredients which includes a hydrophobic meltable binder (hydrogenated castor oil) cum matrixing agent, a hydrophilic meltable binder (polyethylene glycol) which may act as pore former also, and a release controlling polymer (ethyl cellulose). The optimized formulation was found stable. Dissolution profiles of the optimized formulation were found similar to the marketed reference product in different media across the physiological pH range. In conclusion, the explored solvent less process was capable to manufacture the MUPS dosage form of Mebeverine HCl prolonged-release capsules, which is stable and pharmaceutically equivalent with the reference product. The developed process is more beneficial to small and medium scale industry, as it does not require any special and costly equipment, significantly decreases manufacturing cost and increases productivity compared to conventional process, which is mentioned in literature.

Oral Modified Drug Release Solid Dosage Form with Special Reference to Design; An Overview

2020 ◽  
Vol 12 (1) ◽  
pp. 16-25
Author(s):  
Senthilkumar Murugesan ◽  
Byran Gowramma ◽  
Kaviarasan Lakshmanan ◽  
Veera Venkata Satyanarayana Reddy Karri ◽  
Arun Radhakrishnan
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Dosage Form ◽  
Oral Drug Delivery ◽  
Delivery Systems ◽  
Oral Drug ◽  
Active Surface Area ◽  
Prolonged Release ◽  
Modified Release ◽  
Wide Range

Oral drug delivery is the most widely utilized route of administration among all the routes that have been explored for systemic delivery of drugs via pharmaceutical products of different dosage form and this oral route provides maximum active surface area among all drug delivery system for administration of various drugs. The attractiveness of these dosage forms is due to awareness of toxicity and ineffectiveness of drugs when administered by oral conventional method in the form of tablets and capsules. Usually, conventional dosage form produces wide range of fluctuation in drug concentration in the bloodstream and tissues with consequent undesirable toxicity and poor efficiency. The maintenance of concentration of drug in plasma within therapeutic index is very critical for effective treatment. These factors as well as factors such as repetitive dosing and unpredictable absorption lead to the concept of oral modified drug delivery systems like Sustained release, prolonged release, modified release, extended release. These formulations are used to identify drug delivery systems that are designed to achieve or extend therapeutic effect by continuously releasing medication over an extended period of time after administration of a single dose. This review describes the basic information regarding modified release dosage form like designed to release their medication in controlled manner, criteria for selecting modified release dosage form and factors influencing the dosage and release pattern.

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