scholarly journals Contact Lenses as Ophthalmic Drug Delivery Systems: A Review

Polymers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1102
Author(s):  
Paola Franco ◽  
Iolanda De Marco
Keyword(s):  
Contact Lenses ◽  
Pharmacological Action ◽  
Active Principle ◽  
Prolonged Release ◽  
Eye Drops ◽  
Polymeric Support ◽  
Physiological Factors ◽  
Ophthalmic Drugs ◽  
Innovative Methods ◽  
Ophthalmic Drug

Ophthalmic drugs used for the treatment of various ocular diseases are commonly administered by eye drops. However, due to anatomical and physiological factors, there is a low bioavailability of the active principle. In order to increase the drug residence time on the cornea to adequate levels, therapeutic contact lenses have recently been proposed. The polymeric support that constitutes the contact lens is loaded with the drug; in this way, there is a direct and effective pharmacological action on the target organ, promoting a prolonged release of the active principle. The incorporation of ophthalmic drugs into contact lenses can be performed by different techniques; nowadays, the soaking method is mainly employed. To improve the therapeutic performance of drug-loaded contact lenses, innovative methods have recently been proposed, including the impregnation with supercritical carbon dioxide. This updated review of therapeutic contact lenses production and application provides useful information on the most effective preparation methodologies, recent achievements and future perspectives.

scholarly journals Gel-Based Materials for Ophthalmic Drug Delivery

Gels ◽  
2021 ◽  
Vol 7 (3) ◽  
pp. 130
Author(s):  
Roberta Cassano ◽  
Maria Luisa Di Gioia ◽  
Sonia Trombino
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Contact Lenses ◽  
Prolonged Release ◽  
Eye Drops ◽  
Non Invasive ◽  
Ophthalmic Drug Delivery ◽  
Ophthalmic Drug ◽  
In Situ Gelling

The most common route of administration of ophthalmic drugs is the topical route because it is convenient, non-invasive, and accessible to all patients. Unfortunately, drugs administered topically are not able to reach effective concentrations. Moreover, their bioavailability must be improved to decrease the frequency of administrations and their side effects, and to increase their therapeutic efficiency. For this purpose, in recent decades, particular attention has been given to the possibility of developing prolonged-release forms that are able to increase the precorneal residence time and decrease the loss of the drug due to tearing. Among these forms, gel-based materials have been studied as an ideal delivery system because they are an extremely versatile class with numerous prospective applications in ophthalmology. These materials are used in gel eye drops, in situ gelling formulations, intravitreal injections, and therapeutic contact lenses. This review is intended to describe gel-based materials and their main applications in ophthalmology.

The Effect of Photoinitiator Concentration on the Physicochemical Properties of Hydrogel Contact Lenses

2014 ◽  
Vol 679 ◽  
pp. 118-127 ◽  
Author(s):  
Deirdre M. McElroy ◽  
Luke M. Geever ◽  
Clement L. Higginbotham ◽  
Sinead M. Devery
Keyword(s):  
Drug Delivery ◽  
Physicochemical Properties ◽  
Contact Lens ◽  
Contact Lenses ◽  
Delivery Systems ◽  
Eye Drops ◽  
Soft Contact ◽  
Soft Contact Lenses ◽  
Ophthalmic Drug Delivery ◽  
Ophthalmic Drug

Hydrogel soft contact lenses have been investigated as delivery systems for ophthalmic drug products in response to the need for more efficient ophthalmic drug delivery systems. Ocular drugs delivered via eye drops have a low residence time in the eye resulting in as low as 5% bioavailability of the therapeutic agent. This study investigates the effect of varying concentrations of the photoinitiator diphenyl (2,4,6-trimethylbenzoyl)-phosphine oxide (TPO) on the physicochemical properties of hydrogel soft contact lenses for ophthalmic drug delivery purposes. Contact lens samples were synthesised via photopolymerisation with a range of initiator concentration. Gel fraction and swelling results indicated that increasing the photoinitiator concentration increased the efficiency of the gel network and reduced the water content of contact lens samples. Fourier transform infra-red spectroscopy (FTIR) analysis was employed to confirm polymerisation of the lenses and also indicated the presence of residual photoinitiator in lenses with higher TPO concentrations.

scholarly journals Novel Contact Lenses Embedded with Drug-Loaded Zwitterionic Nanogels for Extended Ophthalmic Drug Delivery

Nanomaterials ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 2328
Author(s):  
Zhao Wang ◽  
Xinhua Li ◽  
Xiaojuan Zhang ◽  
Ruilong Sheng ◽  
Qing Lin ◽  
...  
Keyword(s):  
Drug Release ◽  
Contact Lenses ◽  
Eye Drops ◽  
Water Contact ◽  
In Vitro Drug Release ◽  
Molding Method ◽  
Ophthalmic Drug ◽  
One Step

Therapeutic ophthalmic contact lenses with prolonged drug release and improved bioavailability have been developed to circumvent tedious eye drop instillation. In this work, zwitterionic nanogels based on poly(sulfobetaine methacrylate) (PSBMA) were easily fabricated by one-step reflux-precipitation polymerization, with the advantages of being surfactant-free and morphology controlled. Then, the ophthalmic drug levofloxacin (LEV) was encapsulated into the nanogels. A set of contact lenses with varied nanogel-loading content was fabricated by the cast molding method, with the drug-loaded nanogels dispersed in pre-monomer solutions composed of 2-hydroxyethyl methacrylate (HEMA) and N-vinyl-2-pyrrolidone (NVP). The structure, surface morphology, water contact angle (WCA), equilibrium water content (EWC), transmittance, and mechanical properties of the contact lenses were subsequently investigated, and in vitro drug release and biocompatibility were further evaluated. As a result, the optimized contact lens with nanogel-loading content of 8 wt% could sustainably deliver LEV for ten days, with critical lens properties within the range of recommended values for commercial contact lenses. Moreover, cell viability assays revealed that the prepared contact lenses were cytocompatible, suggesting their significant potential as an alternative to traditional eye drops or ointment formulations for long-term oculopathy treatment.

scholarly journals Mechanistic modeling of ophthalmic drug delivery to the anterior chamber by eye drops and contact lenses

2016 ◽  
Vol 233 ◽  
pp. 139-154 ◽  
Author(s):  
Samuel Gause ◽  
Kuan-Hui Hsu ◽  
Chancellor Shafor ◽  
Phillip Dixon ◽  
Kristin Conrad Powell ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anterior Chamber ◽  
Contact Lenses ◽  
Mechanistic Modeling ◽  
Eye Drops ◽  
Ophthalmic Drug Delivery ◽  
Ophthalmic Drug

scholarly journals Therapeutic Ophthalmic Lenses: A Review

Pharmaceutics ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 36
Author(s):  
Nadia Toffoletto ◽  
Benilde Saramago ◽  
Ana Paula Serro
Keyword(s):  
Contact Lenses ◽  
Public Awareness ◽  
Drug Loading ◽  
Developed Countries ◽  
Intraocular Lenses ◽  
Eye Drops ◽  
Non Invasive ◽  
Sustained Drug Delivery ◽  
Drug Eluting ◽  
Ophthalmic Drug

An increasing incidence of eye diseases has been registered in the last decades in developed countries due to the ageing of population, changes in lifestyle, environmental factors, and the presence of concomitant medical conditions. The increase of public awareness on ocular conditions leads to an early diagnosis and treatment, as well as an increased demand for more effective and minimally invasive solutions for the treatment of both the anterior and posterior segments of the eye. Despite being the most common route of ophthalmic drug administration, eye drops are associated with compliance issues, drug wastage by lacrimation, and low bioavailability due to the ocular barriers. In order to overcome these problems, the design of drug-eluting ophthalmic lenses constitutes a non-invasive and patient-friendly approach for the sustained drug delivery to the eye. Several examples of therapeutic contact lenses and intraocular lenses have been developed, by means of different strategies of drug loading, leading to promising results. This review aims to report the recent advances in the development of therapeutic ophthalmic lenses for the treatment and/or prophylaxis of eye pathologies (i.e., glaucoma, cataract, corneal diseases, or posterior segment diseases) and it gives an overview of the future perspectives and challenges in the field.

A Systemic Review on Ophthalmic Hydrogel in Contact Lenses

2016 ◽  
Vol 6 (3) ◽  
Author(s):  
Kurniawansyah Insan ◽  
Mita Soraya
Keyword(s):  
Drug Delivery ◽  
Contact Lenses ◽  
Biological Fluid ◽  
Three Dimensional ◽  
Systemic Review ◽  
Eye Drops ◽  
Great Volume ◽  
Ophthalmic Drug Delivery ◽  
Polymeric Networks ◽  
Ophthalmic Drug

There has been a recent advances in the field of microbiology where hydrogels contact lenses can be extend as the new ophthalmic drug delivery. Rather than the conventional eye drops, these hydrogels can minimize the side effect also prolonged the residence time of drug. Hydrogels are three-dimensional, hydrophilic, and polymeric networks capable of absorbing great volume of water and biological fluid. Hydrogel becomes the leading material for contact lenses because its biocompatibility and transparent characteristic. The purpose of this article is to review on few types of ophthalmic hydrogel in contact lenses and its application.

scholarly journals Ophthalmic Drug Dosage Forms: Characterisation and Research Methods

2014 ◽  
Vol 2014 ◽  
pp. 1-14 ◽  
Author(s):  
Przemysław Baranowski ◽  
Bożena Karolewicz ◽  
Maciej Gajda ◽  
Janusz Pluta
Keyword(s):  
Defense Mechanisms ◽  
Drug Application ◽  
Drug Dosage ◽  
Eye Drops ◽  
Eye Tissues ◽  
Ophthalmic Drug ◽  
Application Frequency

This paper describes hitherto developed drug forms for topical ocular administration, that is, eye drops, ointments,in situgels, inserts, multicompartment drug delivery systems, and ophthalmic drug forms with bioadhesive properties. Heretofore, many studies have demonstrated that new and more complex ophthalmic drug forms exhibit advantage over traditional ones and are able to increase the bioavailability of the active substance by, among others, reducing the susceptibility of drug forms to defense mechanisms of the human eye, extending contact time of drug with the cornea, increasing the penetration through the complex anatomical structure of the eye, and providing controlled release of drugs into the eye tissues, which allows reducing the drug application frequency. The rest of the paper describes recommendedin vitroandin vivostudies to be performed for various ophthalmic drugs forms in order to assess whether the form is acceptable from the perspective of desired properties and patient’s compliance.

scholarly journals Hydrogel Contact Lens for Extended Delivery of Ophthalmic Drugs

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Xiaohong Hu ◽  
Lingyun Hao ◽  
Huaiqing Wang ◽  
Xiaoli Yang ◽  
Guojun Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Contact Lens ◽  
Contact Lenses ◽  
Drug Carriers ◽  
Soft Contact ◽  
Soft Contact Lenses ◽  
Advantages And Disadvantages ◽  
Ophthalmic Drug Delivery ◽  
Ophthalmic Drug ◽  
Polymeric Hydrogels

Soft contact lenses can improve the bioavailability and prolong the residence time of drugs and, therefore, are ideal drug carriers for ophthalmic drug delivery. Hydrogels are the leading materials of soft contact lenses because of their biocompatibility and transparent characteristic. In order to increase the amount of load drug and to control their release at the expected intervals, many strategies are developed to modify the conventional contact lens as well as the novel hydrogel contact lenses that include (i) polymeric hydrogels with controlled hydrophilic/hydrophobic copolymer ratio; (ii) hydrogels for inclusion of drugs in a colloidal structure dispersed in the contact lenses; (iii) ligand-containing hydrogels; (iv) molecularly imprinted polymeric hydrogels; (v) hydrogel with the surface containing multilayer structure for drugs loading and releasing. The advantages and disadvantages of these strategies in modifying or designing hydrogel contact lenses for extended ophthalmic drug delivery are analyzed in this paper.

Pharmacoeconomical approaches for assessing the rational use of ophthalmic drugs in polyclinic settings

2021 ◽  
pp. 143-145
Author(s):  
N.A. Nefedov ◽  
◽  
D.S. Ramonas ◽  
B.G. Khasanov ◽  
A.S. Alexandrov ◽  
...  
Keyword(s):  
Fold Increase ◽  
Eye Drops ◽  
Ophthalmic Drugs ◽  
Rational Use ◽  
Rational Drug ◽  
Acquisition Costs ◽  
The Cost ◽  
Drug Provision ◽  
Combined Drugs

Purpose. To evaluate the results of the rational use of ophthalmic medicines with the use of pharmacoeconomical analysis. Material and methods. With the help of ABC-VEN analysis, a comparative study of the quality of pharmacotherapy and drug provision of patients who were monitored and treated by an ophthalmologist of the polyclinic in 2015 and 2019 was conducted. Results. As a result, it was found that the share of costs for vital drugs increased by 10.1% and amounted to 71.1% in 2019, which corresponds to the standardized criterion (70-80%). There was a reduction in the cost of purchasing secondary drugs by 7.6%, which indicates a rational drug supply of ophthalmic drugs. The most commonly used drugs for the treatment of glaucoma were 27.8% in 2015 and 35.1% in 2019. The share of their acquisition costs was 54.9% and 67.9%, respectively. There was a significant increase in the range and number of drugs for the treatment of patients with glaucoma: a 2.8-fold increase in the number of purchased eye drops for monotherapy and a 12% increase in the number of combined drugs. Conclusion. Pharmacoeconomical analysis showed an optimization of spending money on the purchase of drugs used in ophthalmology: an increase of 10.1% in the share of vital drugs and a decrease of 7.6% in the cost of purchasing secondary drugs. There was an increase in the range and quantity of drugs for the treatment of patients with glaucoma. Key words: ABC-VEN-analysis, drugs, ophthalmology, pharmacoeconomics.

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