ATP-induced changes in rat skeletal muscle contractility

2015 ◽  
Vol 27 (s1) ◽  
pp. S82-S83 ◽  
Author(s):  
A.I. Gabdrakhmanov ◽  
A.E. Khayrullin ◽  
C.H. Grishin ◽  
A.U. Ziganshin
Keyword(s):  
Skeletal Muscle ◽  
Rat Skeletal Muscle ◽  
Muscle Contractility ◽  
Induced Changes

Ischemia/reperfusion-induced changes in intracellular free Ca2+ levels in rat skeletal muscle fibers – an in vivo study

2000 ◽  
Vol 440 (2) ◽  
pp. 302-308 ◽  
Author(s):  
Tamás Ivanics ◽  
Zsuzsa Miklós ◽  
Zoltán Ruttner ◽  
Sándor Bátkai ◽  
Dick W. Slaaf ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Ischemia Reperfusion ◽  
Muscle Fibers ◽  
In Vivo Study ◽  
Rat Skeletal Muscle ◽  
Skeletal Muscle Fibers ◽  
Induced Changes

Contraction-induced changes in TNFα and Akt-mediated signalling are associated with increased myofibrillar protein in rat skeletal muscle

2010 ◽  
Vol 109 (5) ◽  
pp. 839-848 ◽  
Author(s):  
Leonidas G. Karagounis ◽  
Ben B. Yaspelkis ◽  
Donald W. Reeder ◽  
Graeme I. Lancaster ◽  
John A. Hawley ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Myofibrillar Protein ◽  
Rat Skeletal Muscle ◽  
Induced Changes

scholarly journals Rat skeletal muscle contractility: The role of beta-adrenoceptors and nitric oxide system

2011 ◽  
Vol 61 (4) ◽  
pp. 339-348
Author(s):  
Milica Prostran ◽  
R. Stojanovic ◽  
Z. Todorovic ◽  
Sonja Vuckovic ◽  
Katarina Savic-Vujovic ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Skeletal Muscle ◽  
Oxide System ◽  
Rat Skeletal Muscle ◽  
Muscle Contractility ◽  
Beta Adrenoceptors ◽  
Nitric Oxide System

Exercised induced changes of GDNF in rat skeletal muscle at various times after exercise

2007 ◽  
Vol 21 (5) ◽  
Author(s):  
Kyle R Kinnell ◽  
Nathan G. Peplinski ◽  
John M. Spitsbergen
Keyword(s):  
Skeletal Muscle ◽  
Rat Skeletal Muscle ◽  
Induced Changes

Triiodothyronine-induced changes in proton efflux from rat skeletal muscle in vivo

1995 ◽  
Vol 133 (2) ◽  
pp. 260-264 ◽  
Author(s):  
Campbell H Thompson ◽  
Graham J Kemp ◽  
George K Radda
Keyword(s):  
Skeletal Muscle ◽  
Magnetic Resonance ◽  
Transport Processes ◽  
Resonance Spectroscopy ◽  
Rat Skeletal Muscle ◽  
Proton Efflux ◽  
Efflux Rate ◽  
Ph Change ◽  
Induced Changes

Thompson CH, Kemp GJ, Radda GK. Triiodothyronine-induced changes in proton efflux from rat skeletal muscle in vivo. Eur J Endocrinol 1995;133:260–4. ISSN 0804–4643 Hyperthyroidism is associated with muscle weakness, abnormal aerobic metabolism and increased lactate production. Muscle cell acidification during exercise is reduced, suggesting abnormally increased proton efflux. Using 31P magnetic resonance spectroscopy to measure cell pH and phosphocreatine concentration, we quantified effective proton efflux from rat leg muscle in vivo following 10-Hz sciatic nerve stimulation in seven rats injected with triiodothyronine (T3) for 5 days and in 11 controls. Proton efflux during recovery was sigmoidally pH-dependent in both groups but the initial proton efflux rate did not differ (16 ± 3 mmol·kg−1 · min−1 in treated animals vs 15 ± 1 mmol·kg−1·min−1 in controls), despite a significantly smaller pH change from basal in treated animals (0.60 ± 0.04 vs 0.78 ± 0.03 in controls, p = 0.002). The pH dependence of proton efflux can be characterized by an apparent Km, defined as the pH below basal at which proton efflux rate falls to half its start-of-recovery value. This Km was smaller in the T3-treated group (0.44 ± 0.04 vs 0.59 ± 0.03 in controls, p = 0.02). This suggests an increased affinity for protons by cell membrane proton transport processes such as the sodium–proton antiporter and may explain some of the metabolic changes seen clinically in hyperthyroid skeletal muscle. CH Thompson, MRC Biochemical and Clinical Magnetic Resonance Unit, Oxford Radcliffe Hospital Trust, Headington, Oxford OX3 9DU, UK

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