scholarly journals Modulating Neurotrophin Receptor Signaling as a Therapeutic Strategy for Huntington’s Disease

2017 ◽  
Vol 6 (4) ◽  
pp. 303-325 ◽  
Author(s):  
Danielle A. Simmons
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Therapeutic Strategy ◽  
Neurotrophin Receptor ◽  
Receptor Signaling

scholarly journals Impaired TrkB Receptor Signaling Underlies Corticostriatal Dysfunction in Huntington’s Disease

Neuron ◽  
2014 ◽  
Vol 83 (1) ◽  
pp. 178-188 ◽  
Author(s):  
Joshua L. Plotkin ◽  
Michelle Day ◽  
Jayms D. Peterson ◽  
Zhong Xie ◽  
Geraldine J. Kress ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Receptor Signaling ◽  
Trkb Receptor

scholarly journals Early Increase in Extrasynaptic NMDA Receptor Signaling and Expression Contributes to Phenotype Onset in Huntington's Disease Mice

Neuron ◽  
2010 ◽  
Vol 65 (2) ◽  
pp. 178-190 ◽  
Author(s):  
Austen J. Milnerwood ◽  
Clare M. Gladding ◽  
Mahmoud A. Pouladi ◽  
Alexandra M. Kaufman ◽  
Rochelle M. Hines ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Receptor Signaling ◽  
Early Increase

Activating mitochondrial regulator PGC-1α expression by astrocytic NGF is a therapeutic strategy for Huntington's disease

2012 ◽  
Vol 63 (4) ◽  
pp. 719-732 ◽  
Author(s):  
Li-Wen Chen ◽  
Lin-Yea Horng ◽  
Chia-Ling Wu ◽  
Hui-Ching Sung ◽  
Rong-Tsun Wu
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Therapeutic Strategy

scholarly journals Early Increase in Extrasynaptic NMDA Receptor Signaling and Expression Contributes to Phenotype Onset in Huntington's Disease Mice

Neuron ◽  
2010 ◽  
Vol 65 (3) ◽  
pp. 436 ◽  
Author(s):  
Austen J. Milnerwood ◽  
Clare M. Gladding ◽  
Mahmoud A. Pouladi ◽  
Alexandra M. Kaufman ◽  
Rochelle M. Hines ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Receptor Signaling ◽  
Early Increase

scholarly journals Olfactory Dysfunction in Huntington’s Disease

2021 ◽  
pp. 1-10
Author(s):  
Jorge Patino ◽  
Nicholas E. Karagas ◽  
Shivika Chandra ◽  
Nivedita Thakur ◽  
Erin Furr Stimming
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Therapeutic Strategy ◽  
Specific Treatment ◽  
Olfactory Dysfunction ◽  
Cross Cultural ◽  
Common Symptom ◽  
Progressive Decline ◽  
Advanced Stages ◽  
Olfactory Impairment

Olfactory dysfunction is a common symptom in patients with neurodegenerative disorders, including Huntington’s disease (HD). Understanding its pathophysiology is important in establishing a preventive and therapeutic plan. In this literature review, we cover the physiology of olfaction, its role in neurodegeneration, and its characteristics in patients with HD. In the general population, olfactory dysfunction is present in 3.8–5.8%and the prevalence increases significantly in those older than 80 years. For HD, data regarding prevalence rates are lacking and the scales used have been inconsistent or have been restructured due to concerns about cross-cultural understanding. Pathogenic huntingtin deposits have been found in the olfactory bulb of individuals with HD, although no studies have correlated this with the grade of olfactory impairment. Olfactory dysfunction is present in both premanifest and manifest patients with HD, showing a progressive decline over time with more severe deficits at advanced stages. No specific treatment for olfactory impairment in HD has been proposed; identifying and avoiding potential medications that cause olfactory dysfunction, as well as general safety recommendations remain the basis of the therapeutic strategy.

scholarly journals Neurotrophin receptor p75NTR mediates Huntington’s disease–associated synaptic and memory dysfunction

2014 ◽  
Vol 124 (10) ◽  
pp. 4411-4428 ◽  
Author(s):  
Verónica Brito ◽  
Albert Giralt ◽  
Lilian Enriquez-Barreto ◽  
Mar Puigdellívol ◽  
Nuria Suelves ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Neurotrophin Receptor ◽  
Memory Dysfunction
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